DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and pxn-2

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_509834.1	Gene:	pxn-2 / 181288	WormBaseID:	WBGene00004257	Length:	1328	Species:	Caenorhabditis elegans

Alignment Length:	655	Identity:	140/655 - (21%)
Similarity:	226/655 - (34%)	Gaps:	186/655 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PIAALSLLVLSLLTW----THPTIVDAAHPPEI------IRKPQNQGVRVGGVASFYCAARGDPP 64
            ||...::..::..|.    |..::|.....|||      ..|..:...|.|......|.|.|:|.
Worm   316 PITTTTMEPMTTSTMDSMDTTESVVTMTTMPEIDTKIVFEHKQLDTTSRDGETLELKCEASGEPT 380

  Fly    65 PSIVWRKNGKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTI 129
            |:|.|....:|:  |:||...|.:.|  |:|:|.|. ...|...|||||.|| .::.|...::::
Worm   381 PTITWLFEKQKL--TESRKHKLTKNG--SVLKIFPF-LNTDIGQYECVASNG-EESKSHIFSVSL 439

  Fly   130 YEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKDGFL 194
            .|.::     |||...|......:|..|.:.|.|.|.|.|::.|:....::...|.||::.|..:
Worm   440 KESEQ-----PVIIDAPMDTNATIGQQVTLRCNAKGFPVPDVVWLFEGIRIPRRNTRYTISDNNI 499

  Fly   195 Q--IENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCI 257
            :  ||.....|.|.:.|.|.||:|:..:.| ||.|
Worm   500 ELTIEKVTRHDSGVFTCQAVNSVGSAVATA-NLLV------------------------------ 533

  Fly   258 AVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLP 322
                         |:|         :...|.:|::           .||:.:|...:..||:...
Worm   534 -------------GAE---------LTEKVDKLLD-----------DSTIEKIAKEAKQKVEKAL 565

  Fly   323 TAPTDVQISEVTATSVRLEWSYKGPEDLQ---YYVIQYKPKN---ANQAFSEISGIITMY----- 376
            ::..|.|         |:: ..:.|.||.   .:.|..|..:   |.:.:.|...::.|:
Worm   566 SSTKDQQ---------RMD-KIESPNDLSKLFKFAINLKKVDLGKAREIYEESIRLVQMHIDNGL 620

  Fly   377 -YVVRALSPYTEYEFYVIAVNNIGRGPPSAPAT------CTTGDFS------------------- 415
             :....:||...||..:         |.|...|      |.||.|:
Worm   621 AFESAMISPNVSYEAVL---------PVSYVQTLMEKSGCQTGQFAESCEDHCFFSKYRSYDGQC 676

  Fly   416 ------FGGTKMESAPRNVQVRTLSSSTMVITWEPP------ETPNGQVTGYKVYYTTNSNQPEA 468
                  :.|....:..|.:..|..:.....:.||..      |.||.:... :|...|:...|.:
Worm   677 NNHEHPWWGVSEMAFMRLLPPRYENGFNTPVGWEKGKRYNGYEVPNARKVS-RVLIGTDETTPHS 740

  Fly   469 -------SWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQ---------Q 517
                   .| .|.:|:....|...||.|:.........|...|.|... :|::|.         |
Worm   741 HLSAMTMQW-GQFIDHDLTLTAPALTRHSYKEGAFCNRTCENADPCFN-IQLEADDPKLHTGLYQ 803

  Fly   518 GVPSQ--PSNFRATDIGETAVTLQWTKPTHSSE-NIVHYELYWNDTYANQAHHKRISNSEAYTLD 579
            ..|..  ..|..|...|||:...|  :.|:..: |::...|..:..|.|       |..:|..|.
Worm   804 KHPCMEFERNGAACGSGETSPIFQ--RVTYRDQLNLLTSYLDASGIYGN-------SEEQALELR 859

  Fly   580 GLYPD 584
            .||.|
Worm   860 DLYSD 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	32/99 (32%)
		I-set	36..129	CDD:254352	32/98 (33%)
		IG_like	146..227	CDD:214653	25/82 (30%)
		Ig	159..228	CDD:299845	22/70 (31%)
		I-set	234..318	CDD:254352	7/83 (8%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	7/67 (10%)
		fn3	324..404	CDD:278470	16/91 (18%)
		FN3	423..514	CDD:238020	21/103 (20%)
		FN3	520..610	CDD:238020	18/68 (26%)
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470
		PTPc	1476..1731	CDD:214550
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
pxn-2	NP_509834.1	LRRNT	16..43	CDD:396168
		leucine-rich repeat	28..44	CDD:275380
		PRK15370	<35..>155	CDD:185268
		leucine-rich repeat	46..69	CDD:275378
		LRR_8	47..104	CDD:404697
		leucine-rich repeat	70..93	CDD:275378
		leucine-rich repeat	94..116	CDD:275378
		leucine-rich repeat	117..140	CDD:275378
		leucine-rich repeat	141..154	CDD:275378
		Ig	346..432	CDD:416386	31/91 (34%)
		Ig strand B	369..373	CDD:409353	0/3 (0%)
		Ig strand C	382..386	CDD:409353	1/3 (33%)
		Ig strand E	405..410	CDD:409353	2/4 (50%)
		Ig strand F	419..424	CDD:409353	3/4 (75%)
		I-set	445..533	CDD:400151	28/88 (32%)
		Ig strand A'	453..457	CDD:409353	0/3 (0%)
		Ig strand B	460..469	CDD:409353	2/8 (25%)
		Ig strand C	475..480	CDD:409353	1/4 (25%)
		Ig strand C'	483..486	CDD:409353	0/2 (0%)
		Ig strand D	491..496	CDD:409353	2/4 (50%)
		Ig strand E	497..505	CDD:409353	1/7 (14%)
		Ig strand F	512..520	CDD:409353	3/7 (43%)
		Ig strand G	523..533	CDD:409353	4/10 (40%)
		peroxidasin_like	798..1238	CDD:188658	19/76 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900