DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and ptp-4

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001255470.1 Gene:ptp-4 / 177898 WormBaseID:WBGene00010558 Length:1159 Species:Caenorhabditis elegans


Alignment Length:1297 Identity:297/1297 - (22%)
Similarity:475/1297 - (36%) Gaps:416/1297 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   698 PRSHPIILRTQEDVPGDPQDVKATPLNSTS-----------IHVSWKPPLEKDR----------N 741
            ||.|.|.|..........:.:..|..|:|.           |.....|..|..|          :
 Worm     2 PRKHFIFLIFLFWKFDSAESISVTSKNATEALLRCPPAENFIRTHMAPDFETPRLVRRLDWFQDD 66

  Fly   742 GIIRGYH--IHAQELR----DEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDG 800
            .::..|.  |.|...|    .:|:..|..||                    |:::|:.:|.:..|
 Worm    67 SLVASYQQDILADSSRQWWVSDGRYQLIRPF--------------------YTLRVSPVTPEDSG 111

  Fly   801 -------------------DRSAAIVVKTPGGVPVRP-TVSLKIMEREPIVSIELEWERPAQTYG 845
                               .:..|::||     ||.| :..:|.....   ||.|.|     |:.
 Worm   112 TYRCRLETDPLFSSPQSTATQELAVMVK-----PVAPSSPEIKTFTNR---SITLVW-----THN 163

  Fly   846 ELRGYR--LRWGVKDQALKEE----MLSGPQMTKKRFDNLERGVEYEFRVAGSNHIG---IGQET 901
            ..|.:|  ||:.|..:.:.:.    |.:....|....|||.....|.|.|...|..|   .|.||
 Worm   164 AARAHRPILRFSVSVRTVSDNTRFVMAAPSNATTVIVDNLSPYTLYAFSVRAENSAGSSDFGPET 228

  Fly   902 VKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNM 966
            .  |:|...:|..||....||..|.:.:.||..||  :..||.:.:|.|.. :.::..:  .|.|
 Worm   229 T--FRTLGESPNRPPQIQKIRNITSECVEVTITPP--DEMNGELDKYLVLI-QAVNETI--PRKM 286

  Fly   967 TLRKAVFT-----NLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGR-APMSLQA-EATSEQ 1024
            |..|...|     .|..:|:|...:.|....|..| ...|:..||..:.. :|.::.. ....:.
 Worm   287 TFDKPTSTPLTICALSPSTDYALAIEADNGFGTSP-QATLVFHTEDSVPNWSPSTITTLPVVGKP 350

  Fly  1025 TAEIWW--EPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESA--------DLVNLEKFAQY 1079
            ...:.|  .|:.:..|::.|.::|   ..::.|.|:.:.:.::.:.        .||:|....||
 Worm   351 EITVLWPAPPLNATEKVIKYHLYY---KAKNEDQWKIEHLNVSPNGVKSKLFKYRLVDLNPNTQY 412

  Fly  1080 AVAIAARFKNGLGRLS----------EKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPV 1134
            .:.::|....|.|..|          |..||..|  |:..:.:      :.:.|.|         
 Worm   413 RIRVSASTIKGEGAQSADSVAQTDVGEPGTVTFK--DLNFDCK------NGVKLRW--------- 460

  Fly  1135 NYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPP 1199
            ||:.|.::.|                                 ||  |:.|.|:           
 Worm   461 NYEPSVNSKK---------------------------------SP--TFTVKVT----------- 479

  Fly  1200 TKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQF 1264
               ..||.:.....|:..|...:...:|                 |.|.::..::|.:..     
 Worm   480 ---NQTTSLQFNTTMLSLDIIDLSLYDE-----------------YTLRIIVLERSTIDN----- 519

  Fly  1265 LTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDT 1329
                                          .|..:|...|.|.|..:                  
 Worm   520 ------------------------------STILIGKYSDSHQFILK------------------ 536

  Fly  1330 PQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFI 1394
             .|..|.||    |.|       |||:        .|:...|...            |..:|..|
 Worm   537 -DKCSYQSS----FCS-------PGEK--------CAKLTSSAGN------------PRYISVLI 569

  Fly  1395 VSTALIV---LCVV--------------KRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMR 1442
            |..|:|:   :|.|              .::::.|...::.:   ||:....|            
 Worm   570 VIFAIIIFAFICFVIVHFARGSMNFKHLLKKKEKCVYLEEIS---PLVYDSAG------------ 619

  Fly  1443 RLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEY----------ESIEPGQQFTWDNSNL 1497
                       ...||:..|..::|.|..||:.||..::          :|::.|:    .||:.
 Worm   620 -----------QEDIPVELFYGYVEDLNRNDSLKFKTQFQILESQTSGIDSVDSGE----SNSSS 669

  Fly  1498 EHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRM 1562
            :.|..||||.|:.|.:.:|::|   ....|:|||||||.|...:.|||:|||.||..||.|||.|
 Worm   670 DENSQKNRYNNIGAIEATRIRL---NSPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSM 731

  Fly  1563 CWELKTATIVMMTRLEERTRIKCDQYWPTR--GTETYGQIFVTITETQELATYSIRTFQL--CRQ 1623
            .|:.::..||.:|.:.|..:.|||||||::  ..:|:|...||:......|.:|.|...|  .:.
 Worm   732 IWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKA 796

  Fly  1624 GFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDS 1688
            .....|::.||.|..|||||||....|.|.|:.....:  ..:|||:|||||||||:|.||::||
 Worm   797 VPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDI--HSTGPVVVHCSAGVGRSGSYILVDS 859

  Fly  1689 MLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPA----RNLHTHL 1749
            |...:...:.:::.||:|.:|.||..:|||.:||||.|:||.:.|..|:|.|.:    |.||   
 Worm   860 MRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDLFMRYLH--- 921

  Fly  1750 QKLLITEPGETISG---MEVEFKKLSNVKMDSSKFVTANLPCN-KHKNRLVHILPYESSRVYLTP 1810
               .::|  |.::|   |:::|:.:                |: ||:.|.:              
 Worm   922 ---YLSE--ENLNGKTRMQLQFEDI----------------CDCKHQPRCL-------------- 951

  Fly  1811 IHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGRE 1872
               || ||.:.   :.||.....::.  |...:..||.||:.|:.....:|:|.:.....|:
 Worm   952 ---IE-SDVIT---LPGYHRSDEFMV--GSWGNECEDLWRLTWQQKVQTIVILNQRDSFWRK 1004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020
FN3 520..610 CDD:238020
FN3 616..707 CDD:238020 5/8 (63%)
FN3 712..810 CDD:238020 21/143 (15%)
FN3 832..907 CDD:238020 24/83 (29%)
FN3 914..1005 CDD:238020 25/95 (26%)
FN3 1012..1101 CDD:238020 19/109 (17%)
fn3 1106..1198 CDD:278470 12/91 (13%)
PTPc 1476..1731 CDD:214550 106/268 (40%)
PTPc 1503..1731 CDD:238006 99/231 (43%)
PTPc 1763..2022 CDD:214550 22/114 (19%)
PTPc 1791..2022 CDD:238006 17/82 (21%)
ptp-4NP_001255470.1 IG_like <83..120 CDD:214653 8/56 (14%)
FN3 140..232 CDD:238020 28/101 (28%)
FN3 237..326 CDD:238020 25/94 (27%)
FN3 338..435 CDD:238020 17/99 (17%)
PTPc 642..900 CDD:214550 104/266 (39%)
PTPc 675..900 CDD:238006 97/229 (42%)
Y_phosphatase <977..1128 CDD:278528 8/28 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19134
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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