Protein Alignment Lar and C17H12.3

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_001379692.1
• Gene: C17H12.3 / 177443
• WormBaseID: WBGene00015929
• Length: 374
• Species: Caenorhabditis elegans
• Alignment Length: 306
• Identity: 100/306 - (32%)
• Similarity: 151/306 - (49%)
• Gaps: 41/306 - (13%)

  Fly  1447 QTPGMISHPPIPISEFANH-----IERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRY 1506
            |.|.::...|| :.:|...     :|:|:  |..:...:|...:..|.....|.:...|::||||
 Worm    52 QQPQLVQAHPI-VEQFVQRALDYGVEKLR--DEFRQMAKYTRPDMTQNAFNANQSANINETKNRY 113

  Fly  1507 ANVTAYDHSRVQL---PAVEGVVGSDYINANY--CDGYRKHNAYVATQGPLQETFVDFWRMCWEL 1566
            |:|...|.:.|.:   ||     .|||::||:  |. ......::.|||||..|..|||.|..:.
 Worm   114 ADVPCQDQNIVLVAKPPA-----PSDYVHANFVGCP-MVPDKRFICTQGPLDHTVDDFWWMIVQQ 172

  Fly  1567 KTATIVMMTRLEERTRIKCDQYWPT---RGTETYGQIFV-TITETQEL---ATYSIRTFQLCRQG 1624
            |...|||:.:..|..:.||.||||.   ...|..|.|.| .::.|:.:   |...|.|.|:   .
 Worm   173 KVEQIVMLCKTIETGKYKCAQYWPLAMGEKKEVKGGIVVENVSGTKPMDRDAEIQITTLQV---S 234

  Fly  1625 FNDRR-EIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDS 1688
            |.|:: .::.|.::.|||.|||......|:.|...|.    ...|::||||||:||||..:.|:.
 Worm   235 FGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRG----SRVPIVVHCSAGIGRTGTIVAIEY 295

  Fly  1689 MLERMKHEK----IIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAIL 1730
            :|||:...|    :.|:   |..||.||.|.:||:.||::||..:|
 Worm   296 ILERIAENKQCPPMPDL---VKSLRDQRAYSIQTDMQYLYIHRVML 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	89/250 (36%)
		R-PTP-LAR-2	1784..2021	CDD:350402
C17H12.3	NP_001379692.1	PTPc	77..339	CDD:214550	94/280 (34%)