Protein Alignment Lar and ptpn-22

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_500128.2
• Gene: ptpn-22 / 176981
• WormBaseID: WBGene00021507
• Length: 469
• Species: Caenorhabditis elegans
• Alignment Length: 420
• Identity: 120/420 - (28%)
• Similarity: 193/420 - (45%)
• Gaps: 78/420 - (18%)

  Fly  1352 PP---GERPHRPDPNWP-AEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPC 1412
            ||   .::|..|.|..| :.|.|     ||.|.             :|.|..::        |..
 Worm    15 PPEIQEQKPKSPPPPLPTSNPVV-----KDTPN-------------VVPTGDLI--------QFE 53

  Fly  1413 KTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDN-QK 1476
            ...::||.|.|           ..:||...: |....|:       :.||....|.....|. ::
 Worm    54 SEEERAATTVP-----------NGNPVIFEK-NPAMDGL-------LREFLKEEEAYTPQDYLRR 99

  Fly  1477 FSQ---EYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPA----VEGVVGSDYINAN 1534
            |.|   |.|.:....::..:.:....:.::|||.::..||.:||::..    .||     |:||:
 Worm   100 FYQIRVEQEKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSENPEG-----YMNAS 159

  Fly  1535 YCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR--GTETY 1597
            ..........::|.|.||..|..::|:|..|.:.:.:|::.:|.|..:|||::|||.:  .:|.:
 Worm   160 LIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELF 224

  Fly  1598 GQIFVTITETQ--ELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRC-- 1658
            |...:|:.|.:  :...|.:|..::..|...:.|::.||.:..|||||.|......|..:...
 Worm   225 GDYEITLEEEKLFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMEN 289

  Fly  1659 --RALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKI--IDIYGHVTCLRAQRNYMVQTE 1719
              ..::|.:|.|::|||||||||||..|.|:.:.|:||.|.:  |||:|.|..||.||..||||:
 Worm   290 IHEEVSPQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETLHSIDIFGLVMTLRKQRASMVQTQ 354

  Fly  1720 DQYIFIHDAILEAIIC----GVTEVPARNL 1745
            ||:.|:|..|  |..|    |:.|.|..:|
 Worm   355 DQFQFVHRCI--ASYCRRHLGIIEEPKLDL 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	85/250 (34%)
		R-PTP-LAR-2	1784..2021	CDD:350402
ptpn-22	NP_500128.2	PTPc	102..365	CDD:214550	87/269 (32%)