DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and F54F12.1

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_499709.1	Gene:	F54F12.1 / 176727	WormBaseID:	WBGene00010072	Length:	1217	Species:	Caenorhabditis elegans

Alignment Length:	925	Identity:	172/925 - (18%)
Similarity:	320/925 - (34%)	Gaps:	248/925 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1012 APMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDL--------------DDWQTKTV 1062
            ||:..:.::..::..:...|.::        ||...:|.:.|:              .|:.....
Worm   265 APVESKWQSMKDENNQHSMEEIS--------KIQEEITTLPDVSSIINTTDSFANCGSDFHDPKY 321

  Fly  1063 GLTESADLVNLEKFAQYAVAIAARFK--NGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSW 1125
            .::|.:::|.|.......|...:||:  |.|..|:....:.:.|   |.......|...:|.
Worm   322 NISEISEVVELMNQLNLKVRQLSRFEYLNELKNLTVLKDILVNP---PTTDEGKIVVIKNMK--- 380

  Fly  1126 SPP----IRLTPVNYKISFDAMKVFVDSQGFSQTQIVPK--------REIILKHYVKTH-TINEL 1177
            |.|    :....||:|...||::..|........::..|        .|:...|::|.: .:|:|
Worm   381 SEPKFEKVLEILVNFKKDLDALQSAVGEMPKLADEVNGKFKNIGSYHNEVNAPHFLKFYDCLNDL 445

  Fly  1178 S----PFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVK------PDFYGVVNGEEILV-- 1230
            :    |....   :|.|.|..|...|::..:...:.:.||.:|      ..|..|.:.|.:.:
Worm   446 ADDGMPMIQM---ISVIQSIRSLSNPSENAIVNSVISSQPSLKSLQVSGTGFKNVTSPEALALNG 507

  Fly  1231 ILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRN----KPERPNAPYIAA----K 1287
            .||.:.     ||.:.|.:..:..|.:.|:.|..:..:.:..::    :..:.|.....:    |
Worm   508 SLPDSQ-----ISAFNLGMAVQGLSQIKKVQDNRVKLETIKEQHAEIIETSKSNTTLTLSLSRLK 567

  Fly  1288 FPQRSIPFTFHLGSG-----DDYHNFTNRKLER-----EKRYRIFVRA----------------- 1325
            ....|:..|.   ||     ...:.|...|.:|     |...:||.:|
Worm   568 DLSESLSTTL---SGITTFVKTINGFQGLKRKRSTLDFESNGKIFDKASSIKGFTGFDFLAIMDA 629

  Fly  1326 -----------VVDTPQKHLYTSSPFSEFLSLDMREAPP-------------------GERPHRP 1360
                       |:|..:|   .|:...:|.....:|||.                   ..:|...
Worm   630 VKAVDGTKYSSVIDALEK---LSTMDLDFQKYKFKEAPATLKAMDLFFASYASNLAALRPQPTTS 691

  Fly  1361 DPNWPAEPEVSVNRNK---------------------------DEPEILWVVLPLMVSTFIVSTA 1398
            ||.  |...|.:..||                           :|..:|..::..:....:|:..
Worm   692 DPT--AAAPVPIPNNKGSLNGNPSPSSPPLLPPVASSTPAATPEESNMLLYIIGAVGGLLVVAII 754

  Fly  1399 LIVLCVV------KRRRQPCKTPDQAAVTRPLMAA-------------DLGAGPTPSDPVDMRRL 1444
            .::|..|      |:..:|...|....|..|::.|             :|....|.:|...::..
Worm   755 GVILFFVFFQKKKKKEDKPDDPPAPLPVLPPVVPAPAPVVPAPAPVVKELSVDETQADHPSLQSF 819

  Fly  1445 NFQTPGMISHPPIPISEFANH-----IERLKSNDNQKFSQE-YESIEPGQQFTWDNSNLEHNKSK 1503
            ..|...|:....:.:|:....     ..:|.:...|::::. |::|       |   .|:...|.
Worm   820 QLQDTQMMPEESLALSDVVVQGIRVAAAKLCTKSPQEWAEGIYDTI-------W---KLDVMVST 874

  Fly  1504 NRYANVTAYDHS--RVQLPAVEGVVG--SDYINANYCDGYRKHN--AYVATQGPL---------- 1552
            |..||::...|:  ..:...:..:||  ..:||||    ..|..  :::..|||:
Worm   875 NTQANISQRRHTLFLCEPKTMAKLVGFPDPFINAN----VMKFGEISWIMAQGPMDGTEHLEKIS 935

  Fly  1553 -------QETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTE--TYGQIFVT----- 1603
                   :.|....|.:..:.....:..:..:.|....|...|:..:..|  |:|:..||
Worm   936 KVPPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSIN 1000

  Fly  1604 -----ITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTP 1663
                 .|:.:....|::.......|....::.:..|.||||||||.|.:|...|..:|.|.:.
Worm  1001 TKLENFTDKKSFVMYNLEYKNDQWQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESY-- 1063

  Fly  1664 PESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDA 1728
              ...|:|||||||||||..:.|...::....|:..::...|..:|..|...||:..|.:::
Worm  1064 --KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL--- 1123

  Fly  1729 ILEAIICGVTEVPAR 1743
                |:|....|.|:
Worm  1124 ----IVCITKGVMAK 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020	17/104 (16%)
		fn3	1106..1198	CDD:278470	22/108 (20%)
		PTPc	1476..1731	CDD:214550	66/290 (23%)
		PTPc	1503..1731	CDD:238006	61/262 (23%)
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
F54F12.1	NP_499709.1	Y_phosphatase	879..1127	CDD:278528	60/262 (23%)
F54F12.1	NP_499709.1	PTPc	884..1127	CDD:238006	59/257 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010