DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and ptp-3

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_001263671.1	Gene:	ptp-3 / 174685	WormBaseID:	WBGene00004215	Length:	2248	Species:	Caenorhabditis elegans

Alignment Length:	2235	Identity:	793/2235 - (35%)
Similarity:	1160/2235 - (51%)	Gaps:	311/2235 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 AHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGTQSRYTVLEQPGGISILRI 97
            |:|..::.:|.:..|......||:|.|.|:|.||::||.|||.:: ..:|.::.....|:|.||.
Worm    89 AYPARLVVRPDSSTVVDESKISFFCRADGNPLPSVIWRVNGKSIT-DHNRISIKSLATGLSTLRF 152

  Fly    98 EPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCK 162
            |.|....:.....|.|:|||.:.|.|:|:||:...||.|.|||.|...|..:.:|.|.|..::|:
Worm   153 ERVSLDDNATVVSCSADNGVANPVVAEASLTVVPRDKVPIGFPQIELHPSLKSVEQGKTAYVSCR 217

  Fly   163 AIGNPTPNIYWIKNQTKVDM-SNPRYSL----KDGFLQIENSREEDQGKYECVAENSMGTEHSKA 222
            ..|:|...:.|:::...:|: ::.|||:    ..|.|.|:::||||||||||:|.|::|..||||
Worm   218 VRGDPRAKVLWLRDLIPLDIRADGRYSVSTIGNPGALMIQHAREEDQGKYECIARNTLGVAHSKA 282

  Fly   223 TNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHVKWMKGSED---LTPENEMPIG 284
            .|||||||||||.||...|....|.:|.|:||:|:|||.|||.|.|.|  .|   |...:..|||
Worm   283 ANLYVKVRRVPPYFSYKLERQYVVGVGGNINLTCVAVGYPMPRVFWKK--TDLMVLDDPSTAPIG 345

  Fly   285 RNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGP-- 347
            :|||.|.:::.:.|:||:|.|.||.|::.:.|..:.||..|.::.:|.||:.||.:.|  |.|
Worm   346 KNVLTLTHVESTENFTCVAVSALGNIEATTTVIAKELPPPPVNIVVSSVTSESVVITW--KPPKY 408

  Fly   348 -EDLQYYVIQYKPKNAN-------------------QAFSE-------ISGIITMYYVVRALSPY 385
             |.:..||:.|:.|:.|                   :.:||       ....:....|:..|..:
Worm   409 NEAINKYVVNYRLKSENKDDAALFAKDSRAEDESDSERYSEGRSSRGKTMETLENSLVIDGLVAF 473

  Fly   386 TEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNG 450
            ..|||.|.:...:|.|..|.|....|..     :|..:||.:.|.|:|:..::::.|.|.|.|||
Worm   474 QTYEFTVRSAGPVGVGLESLPVEAQTKP-----SKPATAPVSPQARSLNRDSILVKWGPCEQPNG 533

  Fly   451 QVTGYKVYYTTN-SNQPEASWNSQMVDNSE-LTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQV 513
            .:||||||||.: ...|...|......:.| :||::.|.|.:.|.|||.|..|.|..|:||.|.|
Worm   534 LITGYKVYYTNDLVTTPIREWKQHDAKSDEFMTTINGLEPDSRYFVRVIAQNSEGDSPLSTLVTV 598

  Fly   514 KAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTL 578
            ..:||:|.||.......:....:.|.|.||.:||. :|.|.:.:| |...:......|..|.:.:
Worm   599 ATRQGIPGQPPMLTVKALDSRRMQLTWDKPLYSSP-VVGYTVRYN-TSDGEKELTLTSPHEKHVV 661

  Fly   579 DGLYPDTLYYIWLAARSQRGEGATTPP--------IPVRTKQYGAPPRNITAIATSSTTISLSWL 635
            .||:||..||..:||.|.||:|..|.|        ||:      :.|..::|.||||.::.:.|.
Worm   662 TGLHPDKYYYFRVAAYSDRGQGEFTEPMISKTIASIPL------SSPTIVSAAATSSKSVEIRWK 720

  Fly   636 PPPVERSNGRIIYYKVFF-------------VEVGREDDEATTMTLNM--------TSIVLDELK 679
            .|..::.||.:..|::.:             ||...:.|::::....|        ||.||.:|.
Worm   721 GPEQKKLNGVLTAYRINYFRLEDSKTANLESVEYDEDMDDSSSFLDRMSVVVPSDATSYVLSDLL 785

  Fly   680 RWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGII 744
            .::.|:|.|.|.|..|.||.|...:::|.||||..|::..|...::||:.::|..|..  .||.:
Worm   786 PYSSYEITVAASTMDGYGPESSIRVVKTLEDVPSAPRNFNAELTSATSVKLTWDAPAA--ANGAL 848

  Fly   745 RGYHIHAQE------------------LRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQV 791
            .||:::...                  :||..|.:              |.:..|.|:|:||.::
Worm   849 LGYYVYLDRMVNGEPVVEKGSKKRIVMIRDSSKRY--------------FELDSLDPNTEYSFRL 899

  Fly   792 AALTRKGDGDRSAAIVVKTPGGVPVRP-TVSLKIMEREPIVSIELEWERPAQTYGE--LRGYRLR 853
            .|..|.|||:.|....:.|.|..|..| .||:.:...||.|...:||:.|.....|  :..|.|
Worm   900 NAFNRNGDGEFSERKSIITQGIPPEAPEIVSVSLDRDEPPVVARIEWKMPKMKPNETPIEKYNL- 963

  Fly   854 W----GVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGG 914
            |    |..|..:|.:.:.|..:: .....|..||.|:..:|..|..|..|...:...||.|:|.|
Worm   964 WLRAQGYPDSYVKAKTVDGTDLS-TTISGLWMGVVYDVLLAAENREGRSQNATETIATPVGSPDG 1027

  Fly   915 PPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDV----------QFHKKID-HGLGSERNMTL 968
            .|.::........:: |:|.||:.|.|||.||.|..          ::.:.:. ....|...:.:
Worm  1028 EPIDVQYEVMKGKIV-VSWRPPSEEKRNGNITSYKAILSAMDATADRYEQPVPAPSTSSTFEVNV 1091

  Fly   969 RKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETE-RDMGRAPMSLQAEATSEQTAEIWWEP 1032
            |:|          |:|:|.|.|.:|.||:|..|.:..: ..:...|.:::.||||..||.:.|:.
Worm  1092 RRA----------YLFKVAAATMKGIGPYSPVLTINPDPAALVGPPTNVRVEATSNSTAVVQWDF 1146

  Fly  1033 VTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFA---------QYAVAIAARFK 1088
            .:.:......|..:......|.:.|:...|   .|.|..|.::||         .||..:.|...
Worm  1147 ESQKADSFVVKYMHEPGNRMDTEKWKQLPV---VSIDKENPKRFAVVSDLNAHKPYAFCVLAVKN 1208

  Fly  1089 NGLGRLSEKVTV--RIKPEDVPLNLRAHDVSTHSMTLSW--SPPIRLTPVNYKISFDAMKVFVDS 1149
            |..|..|:..||  .:.|..:..|||....:::|:.|:|  :.|   ..|.:.::....|.:|:.
Worm  1209 NRQGPCSDPPTVLESVTPTYMVQNLRVLWKTSNSVQLTWEYNGP---RNVGFYVNHTGRKDYVNH 1270

  Fly  1150 QGFSQTQIVP--KREIILKH--YVKTHTINELSPFTTYNVNV---SAIPSDYSYRPPTKITVTTQ 1207
            :...:|...|  .:::..||  |:.|:    |.|...|.::|   :..|....|.|...:|:|..
Worm  1271 ELQEKTMSTPGFGQDVDEKHREYLWTN----LRPHMMYTIHVGVRTLPPGARKYWPQEVVTITDP 1331

  Fly  1208 MAAPQPMVKP--DFYGVVNGEEILVILPQASEEYGPISHYYLVVVP-----EDKSNLHKI----- 1260
            ...|...|..  |..|...|::::.:.| |:|||||||||::::||     ||..||..|
Worm  1332 TGPPFVDVPKLVDSSGTQPGQQMIRLTP-ATEEYGPISHYWIILVPANYSTEDVVNLDPIELEKA 1395

  Fly  1261 ---------------PDQFLT-------DD-----LLPGRNKPERPNAP--YIAAKFP------- 1289
                           |.:.|.       ||     ..|...:..|...|  |:.|:..
Worm  1396 TAEKRAQLARSLSVSPSKKLKRKASEVGDDSQSASYHPKEKRARRATVPGAYVTARLSADRVKQQ 1460

  Fly  1290 -QRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPP 1353
             :.:.||.  :|....|..|||..||....||:.:||..   :..:.|...|.:       .||.
Worm  1461 YRNNQPFI--VGDSQLYDGFTNYPLEHNLHYRLMMRAFA---KNDVRTKDSFEQ-------RAPM 1513

  Fly  1354 GERPHRP-DPNWPAEPEV--SVNRNKDEPEILWV--VLPLMVSTFIVSTALIVLCVVKR--RRQP 1411
            .|:..|. ..:...||..  |..|...:....||  .:..:|...||.   :::|...|  ::..
Worm  1514 SEKLSRMYSDSVLTEPFTIKSALRGASQKSSPWVGACIAFLVLFSIVG---MLICWWLRCNKKSA 1575

  Fly  1412 CKTPDQAAVTRPLMAADL--GAGPTPSD------------------------------------- 1437
            .:.|...::|:..:..::  |.|..|.:
Worm  1576 GRHPRHGSITKVALTGNIMNGGGGIPGETSKLLSTSNEYGRQIMNPYEQMNGNHHMESSMDLYPL 1640

  Fly  1438 PVDMRRLNFQTP---------------GMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPG 1487
            |....|.|...|               ..:|||.:||:|.|||||||:.|:|..|..|:||||.|
Worm  1641 PTSHSRSNGYAPVPVAIPSLPNNGNNMTTVSHPAVPIAELANHIERLRMNNNAGFQSEFESIETG 1705

  Fly  1488 QQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPL 1552
            |.|||::|:.:.||.|||||||.|||||||.|..|||..|.|||||||.|||.|..:|:||||||
Worm  1706 QHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPL 1770

  Fly  1553 QETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRT 1617
            .|||.|||||.||.::.||||:|.||||:|:|||||||:|||.|||.|.||:.|:..||.|::||
Worm  1771 PETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRT 1835

  Fly  1618 FQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGC 1682
            .:|...|..:.||||.||:||||||||||||.|||.||:|.:.|.|.::||:|.|||||:||||.
Worm  1836 MRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGA 1900

  Fly  1683 YIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHT 1747
            :||||.||||::::..:||||.||.|||||:||||||:||||||||:|:|:..|.|||||..||.
Worm  1901 FIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQ 1965

  Fly  1748 HLQKLLITEP-GETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPI 1811
            ||.  ::::| .:.:||:::||:.|:.:|..|::...||||.|:.|||::..:||:|:||.:..:
Worm  1966 HLH--ILSQPSADQLSGIDMEFRHLTTLKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLL 2028

  Fly  1812 HGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQ 1876
            .|.:||||:|||:||||:.|.||||.|.|..:.|.||||.:|||||.|:.||.:..|.|:|:|..
Worm  2029 PGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSD 2093

  Fly  1877 YWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFI 1941
            |||.|..|:....||:|:|||:|..|.||||:::|......||||||.|::||:.|.|.:.:.|:
Worm  2094 YWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFL 2158

  Fly  1942 DFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAM 2006
            ||:.|||.|..|||..|||||||.:|.||:.|||.|||:|:||:.|.|:|||.||::||::|..|
Worm  2159 DFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNM 2223

  Fly  2007 VQTEDQYHFCYRAALEYLGSFDNYT 2031
            :|..:||||.|.||.|||.::||::
Worm  2224 IQEPEQYHFLYLAAYEYLAAYDNFS 2248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	32/93 (34%)
		I-set	36..129	CDD:254352	31/92 (34%)
		IG_like	146..227	CDD:214653	34/85 (40%)
		Ig	159..228	CDD:299845	31/73 (42%)
		I-set	234..318	CDD:254352	37/86 (43%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	31/70 (44%)
		fn3	324..404	CDD:278470	25/108 (23%)
		FN3	423..514	CDD:238020	37/92 (40%)
		FN3	520..610	CDD:238020	31/97 (32%)
		FN3	616..707	CDD:238020	29/111 (26%)
		FN3	712..810	CDD:238020	26/115 (23%)
		FN3	832..907	CDD:238020	19/80 (24%)
		FN3	914..1005	CDD:238020	26/101 (26%)
		FN3	1012..1101	CDD:238020	25/99 (25%)
		fn3	1106..1198	CDD:278470	22/100 (22%)
		PTPc	1476..1731	CDD:214550	166/254 (65%)
		PTPc	1503..1731	CDD:238006	152/227 (67%)
		PTPc	1763..2022	CDD:214550	132/258 (51%)
		PTPc	1791..2022	CDD:238006	121/230 (53%)
ptp-3	NP_001263671.1	I-set	93..184	CDD:254352	31/91 (34%)
		Ig	106..185	CDD:299845	30/79 (38%)
		IG_like	201..287	CDD:214653	34/85 (40%)
		Ig	212..288	CDD:299845	31/75 (41%)
		IG_like	302..378	CDD:214653	32/77 (42%)
		Ig	309..377	CDD:299845	31/69 (45%)
		FN3	383..499	CDD:238020	28/117 (24%)
		FN3	507..600	CDD:238020	38/92 (41%)
		FN3	605..693	CDD:238020	29/89 (33%)
		FN3	700..813	CDD:238020	29/112 (26%)
		FN3	818..918	CDD:238020	26/115 (23%)
		FN3	923..1020	CDD:238020	26/98 (27%)
		FN3	1027..1116	CDD:238020	26/99 (26%)
		fn3	1125..1213	CDD:278470	21/90 (23%)
		PTPc	1694..1949	CDD:214550	166/254 (65%)
		PTPc	1720..1949	CDD:238006	152/228 (67%)
		PTPc	1980..2239	CDD:214550	132/258 (51%)
		PTPc	2008..2239	CDD:238006	121/230 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165286
Domainoid	1	1.000	333	1.000	Domainoid score	I603
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H88669
Inparanoid	1	1.050	1243	1.000	Inparanoid score	I84
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47937
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	1	1.000	-	-		oto20253
orthoMCL	1	0.900	-	-		OOG6_100623
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.930