DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and dep-1

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001254192.1 Gene:dep-1 / 174437 WormBaseID:WBGene00009717 Length:1367 Species:Caenorhabditis elegans


Alignment Length:1645 Identity:338/1645 - (20%)
Similarity:545/1645 - (33%) Gaps:642/1645 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   308 GQID-SVSVVKVQSL---PTAP------TDVQISE--VTATSVRLEWSYKGPEDLQ-YYVIQYKP 359
            ||.| |.|::|.:|:   |.||      :|:|::|  :|..:::.: ||     || .:.|:|:.
 Worm   114 GQKDGSTSLIKEESVVMDPRAPDFRSMDSDIQVAEHNITMRTIKND-SY-----LQDSFSIEYRQ 172

  Fly   360 KNANQAFS-----EISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAP--ATCTTGDFSFG 417
            .|.::.|.     :|.....:.:.:..|:...:|...|||..:   |..|.|  :|.||      
 Worm   173 INPDKKFPVLQILDIPEQKNLEFYLGNLNSGFDYSVRVIAHKD---GMSSRPWISTLTT------ 228

  Fly   418 GTKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTG---YKVYYTTNSNQPEASWNSQMVDNSE 479
               ..|..:.|.:...:.|.:.::|:     |.:.:|   |.:.|:..|. |..|.|..:.....
 Worm   229 ---KPSPLKEVNINQNAGSCVEVSWQ-----NDEFSGADFYTIQYSLQST-PNNSTNMTIPSTES 284

  Fly   480 LTTVSELTPHAIYTVRVQAY----TSMGAGPMSTPVQVKAQQGVPSQPSNFRA-TDIGETAVTLQ 539
            ..::.:      ..::.:||    |....|.:|.|:..|.|.. |..|.:||. .|:......|.
 Worm   285 SISICD------SMLQGEAYQIIATVQKGGQVSEPLITKFQLR-PLPPIDFRVRADLKRGKYKLL 342

  Fly   540 WTKPTHS-------------SENIVHY----------ELYWND--------------TYANQAHH 567
            ...||.|             :|..|:|          ::.|.:              :.||::..
 Worm   343 AELPTSSKIDKCQITVAGDEAERSVNYANIEQTKSGHKICWFNFALSPGERFDFSISSMANESAS 407

  Fly   568 KRISNSEAYT------------------LDGLYPDTLYY------IW---LAARSQRGEGATTPP 605
            :::..|...|                  ::.::|.:..:      ||   :.|.|......|   
 Worm   408 QKLQKSIVLTPAFDFNAFGLTLQESNGGIELIWPKSEVFMTRVKDIWNKVVGAESLLNMRIT--- 469

  Fly   606 IPV-------RTKQYGAPPRNITAI---------------------------------------- 623
             |:       :|.::...|:||..:                                        
 Worm   470 -PIGNNDETDKTLKFETSPKNIDPVFAKNLVKGACYRVQLFTVTKTGIISETRHNETIRMSSPAV 533

  Fly   624 -----------AT---------SSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTL 668
                       ||         .||:||...:...|...||:.::            |:...:|.
 Worm   534 NVSLESVTRSSATLRIVFSTHHDSTSISNCQMHIVVRDMNGKSVF------------DKRMQLTA 586

  Fly   669 NMTSIV-LDELKRWTEYKI--WVLAGTSVGDGPRSHPIILR--------TQEDVPGDPQDVKATP 722
            ....:: ||.|..:.:|.:  .::.|:...:.|:. |...|        |::|.|...||:|..|
 Worm   587 TFAPLLNLDGLSPFHKYTVNTQIICGSGSSETPQC-PAATRTMRQLSFSTRQDKPAAVQDLKVEP 650

  Fly   723 LNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPD--- 784
            |||.|:.::|.||...  |||:..|.::..::..            |...|::..|:..:.|   
 Worm   651 LNSYSVMLTWLPPALP--NGILTHYAVNVTKIGS------------DETRTIDVGVSSNRSDHTV 701

  Fly   785 ----------TKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWER 839
                      ..||..|.|:|..|.|:.|           ||.||||:.:| ..|:.::      
 Worm   702 QVVIDELFGGHTYSFSVRAVTEAGFGENS-----------PVVPTVSMPLM-APPVPTV------ 748

  Fly   840 PAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKI 904
                                        .|.:.|:.              .||:           
 Worm   749 ----------------------------APMIMKES--------------VGSH----------- 760

  Fly   905 FQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTR-EHRNGIITRYDVQFHKKIDHGLGSERNMTL 968
                         |:.:||           |.|. ::|||.|.::.:                  
 Worm   761 -------------NMIVRF-----------PTTMFDNRNGEIKQFAI------------------ 783

  Fly   969 RKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPV 1033
                                                           :.:|.|::::...|.|  
 Worm   784 -----------------------------------------------IVSETTADESINRWIE-- 799

  Fly  1034 TSRGKLLGYKIFYTMTAVEDLDDWQTKTVGL------TESADLVNLEKFAQYAVAI---AARFKN 1089
            :..|.       ||...|:..|.|.:....|      .:..|:...|:..:....:   |.|..|
 Worm   800 SDNGT-------YTWQQVQRFDVWPSYVAKLQDIQKVKQDVDVSIFEELGEDETCLEVRADRICN 857

  Fly  1090 GLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQ 1154
            |..|.:.|..|||:                   |..||.:                |.||     
 Worm   858 GPLRSASKYRVRIR-------------------LFTSPTL----------------FTDS----- 882

  Fly  1155 TQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAP-------- 1211
                                                       ||::: :||..|.|        
 Worm   883 -------------------------------------------PPSQV-MTTGSATPAIPLLTVV 903

  Fly  1212 QPMVKPDFYGVVNGEEILVI--------LPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDD 1268
            ..::...|.|:| |...|..        |..|:.:.||                           
 Worm   904 AVLIVIAFVGIV-GTIFLFFWNRTKKARLAAAAFKNGP--------------------------- 940

  Fly  1269 LLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKH 1333
                 :|.:......:.....:|:......||                      :.|....|...
 Worm   941 -----SKEKESQWEALKMMMAERAADCLAKLG----------------------LDATTPPPSST 978

  Fly  1334 LYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTA 1398
            ..::||.|  .|..|.:.  |..||...||..........|.:..                    
 Worm   979 TSSNSPTS--TSTTMTDC--GSNPHLGAPNAGGHRRTRSLRERTG-------------------- 1019

  Fly  1399 LIVLCVVKRRRQPCKTPDQAAVTR-PLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEF 1462
                  |:.|.:...:   ..|.| ||.....||....|.||                  .|.:|
 Worm  1020 ------VEHRLERLSS---GPVHRTPLYTVVTGANTNKSRPV------------------RIEDF 1057

  Fly  1463 ANHIERLKSNDNQKFSQEYE---SIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEG 1524
            |:|:..:.::.:.:||:||:   ::..||...  .|.|..|:.|||:.|:.:||||||:|.....
 Worm  1058 ADHVRLMSADSDFRFSEEYDMMRNVGVGQSVA--ASELPINRPKNRFTNIPSYDHSRVKLSNPNN 1120

  Fly  1525 VVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYW 1589
            :.|.|||||||..|:.....::|.||||..|...||:|.||.:...|:.:|:..|:.|.||.|||
 Worm  1121 IEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYW 1185

  Fly  1590 PTRGT--ETYGQIFVTITETQELATYSIRTFQLCRQGFNDR--REIKQLQFTAWPDHGVPDHPAP 1650
            |....  ..||.|.|||...:|...:.||..:|.:.|.:.|  |.::...:.||||.|.|.||..
 Worm  1186 PDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNG 1250

  Fly  1651 FLQFLRRCRALTP--PESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRN 1713
            .:||.|..|...|  |.:.|.||||||||||:|.:|.||.:|:.......||::|.|..:|.:|.
 Worm  1251 IIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERC 1315

  Fly  1714 YMVQTEDQYIFIHDAILEAI 1733
            .|||.|.||||||..||:.:
 Worm  1316 QMVQNEQQYIFIHYCILQVL 1335

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352 5/10 (50%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 5/9 (56%)
fn3 324..404 CDD:278470 21/93 (23%)
FN3 423..514 CDD:238020 18/97 (19%)
FN3 520..610 CDD:238020 24/161 (15%)
FN3 616..707 CDD:238020 22/161 (14%)
FN3 712..810 CDD:238020 28/110 (25%)
FN3 832..907 CDD:238020 4/74 (5%)
FN3 914..1005 CDD:238020 9/91 (10%)
FN3 1012..1101 CDD:238020 19/97 (20%)
fn3 1106..1198 CDD:278470 6/91 (7%)
PTPc 1476..1731 CDD:214550 110/263 (42%)
PTPc 1503..1731 CDD:238006 101/233 (43%)
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
dep-1NP_001254192.1 FN3 640..736 CDD:238020 31/120 (26%)
PTPc 1072..1333 CDD:214550 110/262 (42%)
PTPc 1098..1333 CDD:238006 101/234 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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