DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lar and F55H12.5

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_492395.2	Gene:	F55H12.5 / 172700	WormBaseID:	WBGene00010136	Length:	287	Species:	Caenorhabditis elegans

Alignment Length:	303	Identity:	72/303 - (23%)
Similarity:	115/303 - (37%)	Gaps:	72/303 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1451 MISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLE---------HNKSKNRY 1506
            |:|  |....:|.|      |..|.|      |.|.|....:..:.||         ..|.||..
Worm    33 MLS--PKKFCDFIN------SKTNSK------SFEAGVAEFYKETYLESPTFFNYFKSPKDKNFS 83

  Fly  1507 ANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFV-DFWRMCWELKTAT 1570
            .||..||.:||.:|      |.||.:|::.||. |.|.|:..|.|...:.. ||:::...:|...
Worm    84 ENVWLYDATRVIVP------GVDYYHASWVDGL-KPNQYILAQAPRDASAAKDFFKLLEHVKAEG 141

  Fly  1571 IVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYS---IRTFQLCRQGFNDRREIK 1632
            :::                 ..|.:.:..   .||...|..|..   :.|..:...|.:    :|
Worm   142 LIV-----------------AEGADEFSS---AITAKFEKGTGKNDFVSTAVIKENGLH----LK 182

  Fly  1633 QLQFTAWPDHGVPDHPAPFLQFLRRCRA-LTPPESGPVIVHCSAGVGRTGCYIVIDSMLER-MKH 1695
            .::|..|.:   |.........|.:.|. |..|..||:::.|..|..::|....||:..:| |||
Worm   183 AIKFCRWAE---PLSAIEINDMLEKSRKYLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKH 244

  Fly  1696 EKIIDIYGH---VTCLRAQRNYMVQTEDQYIFIHDAILEAIIC 1735
            .|.    .|   :..:|..|:....|.|.|....::::|  :|
Worm   245 GKA----KHTDTIKQIRFMRSNTFDTFDSYDLGINSLIE--LC 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470
		PTPc	1476..1731	CDD:214550	63/272 (23%)
		PTPc	1503..1731	CDD:238006	56/236 (24%)
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
F55H12.5	NP_492395.2	PTPc	74..270	CDD:214550	56/233 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810