DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Lifr

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001345522.1 Gene:Lifr / 16880 MGIID:96788 Length:1092 Species:Mus musculus


Alignment Length:1165 Identity:213/1165 - (18%)
Similarity:377/1165 - (32%) Gaps:419/1165 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 TPNIYWIKNQ-TKVDMSNPRYSLKDGFLQIE----NSREEDQGKYECVAENSMGTEHSKATNLYV 227
            |||:.|:.:. |.:.::.....||.|...::    |.|     .::|.....:|.......::.:
Mouse    22 TPNLPWLLSALTLLHLTMHANGLKRGVQDLKCTTNNMR-----VWDCTWPAPLGVSPGTVKDICI 81

  Fly   228 KVRRVPPTF--SRPPETISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQL 290
            |.|     |  ..|.||       :|:.:..::.|.....:.::.|.:                 
Mouse    82 KDR-----FHSCHPLET-------TNVKIPALSPGDHEVTINYLNGFQ----------------- 117

  Fly   291 INIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQIS-EVTATSVRLEWSYKG---PEDLQ 351
                        :..||.:.|      |..:|..|..:.:| :...:|:.|:|:.:|   |.   
Mouse   118 ------------SKFTLNEKD------VSLIPETPEILDLSADFFTSSLLLKWNDRGSALPH--- 161

  Fly   352 YYVIQYKPKNANQAFSEISGIITMYYVVRAL-SPYTEYEFYVIAVNNIGRGPPSA---------P 406
                   |.||.             :.::.| :|.|| ...::.:|.:..|..:.         |
Mouse   162 -------PSNAT-------------WEIKVLQNPRTE-PVALVLLNTMLSGKDTVQHWNWTSDLP 205

  Fly   407 ATCTTGDFS---------FGGTKMES--AP-------RNVQVR-------TLSSSTMVI-TWEPP 445
            ..|.|...|         |.|.|..|  :|       ||.:..       .|:.|.|.| ...|.
Mouse   206 LQCATHSVSIRWHIDSPHFSGYKEWSDWSPLKNISWIRNTETNVFPQDKVVLAGSNMTICCMSPT 270

  Fly   446 ETPNGQV---------------------------TGYKVYYTTNSN----------QPE------ 467
            :..:||:                           :|..:.:.|:.:          .|:      
Mouse   271 KVLSGQIGNTLRPLIHLYGQTVAIHILNIPVSENSGTNIIFITDDDVYGTVVFAGYPPDVPQKLS 335

  Fly   468 ----------ASWNSQMVD------NSELTTVSELTP-----HAI-------YTVRVQA------ 498
                      .|||...:.      |:|.|....::.     |.|       |.:.||.      
Mouse   336 CETHDLKEIICSWNPGRITGLVGPRNTEYTLFESISGKSAVFHRIEGLTNETYRLGVQMHPGQEI 400

  Fly   499 --YTSMGAGPMSTPVQVKAQQGV---------PSQPSNFRATDIGETAVTLQWTKPTHSSE-NIV 551
              :|..|..|:.     :||..|         |..|::.:..||..|.||..|..|.:.:: |::
Mouse   401 HNFTLTGRNPLG-----QAQSAVVINVTERVAPHDPTSLKVKDINSTVVTFSWYLPGNFTKINLL 460

  Fly   552 HYELYWNDTYANQAHHKRISNSEAYT----LDGLYPDTLY---------YIWLAAR-SQRGEGAT 602
            ............:..:..|..:|..|    :|.|.|.|.|         ..|..:| |......|
Mouse   461 CQIEICKANSKKEVRNATIRGAEDSTYHVAVDKLNPYTAYTFRVRCSSKTFWKWSRWSDEKRHLT 525

  Fly   603 TPPIPVR----TKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEA 663
            |...|.:    .:::.:..:|:.          :.|.|.|:..:||:|:.|.|            
Mouse   526 TEATPSKGPDTWREWSSDGKNLI----------VYWKPLPINEANGKILSYNV------------ 568

  Fly   664 TTMTLN-MTSIVLD----------ELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQD 717
             :.:|| .|..||:          :|.: .:|.|.|:|..|.|..|   |..:.:.| :|.|...
Mouse   569 -SCSLNEETQSVLEIFDPQHRAEIQLSK-NDYIISVVARNSAGSSP---PSKIASME-IPNDDIT 627

  Fly   718 VKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFD-----------VV 771
            |:........|.::|:.......:.:|:..:           ...:||...|           |:
Mouse   628 VEQAVGLGNRIFLTWRHDPNMTCDYVIKWCN-----------SSRSEPCLLDWRKVPSNSTETVI 681

  Fly   772 DTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIV----- 831
            ::.:|     ||..:|:..:...|.:               |..:..::...:.|..|||     
Mouse   682 ESDQF-----QPGVRYNFYLYGCTNQ---------------GYQLLRSIIGYVEELAPIVAPNFT 726

  Fly   832 -------SIELEWER-PAQTY-GELRGYRLRW--GVKD-----------QALKEEMLSGPQMTKK 874
                   ||.::|:. |.:.. |.||||...:  |.:|           ..:|.:.::.......
Mouse   727 VEDTSADSILVKWDDIPVEELRGFLRGYLFYFQKGERDTPKTRSLEPHHSDIKLKNITDISQKTL 791

  Fly   875 RFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTP-----------DV 928
            |..:|:....|...:....|.|:|.|......|.|.:.|     :.|....|           .:
Mouse   792 RIADLQGKTSYHLVLRAYTHGGLGPEKSMFVVTKENSVG-----LIIAILIPVAVAVIVGVVTSI 851

  Fly   929 LCV---TW-------DPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLE------ 977
            ||.   .|       |.|..|:...:      ||.|.:..|..:.:.:.:......|:|      
Mouse   852 LCYRKREWIKETFYPDIPNPENCKAL------QFQKSVCEGSNALKTLEMNPCTPNNVEVLESRS 910

  Fly   978 -----ENTEYIFRV--RAYTKQGAGPFSDKL------IVETE------RDMGRAPMSL------- 1016
                 |:||.|..|  |...:....|.:..:      |:|.|      .::|.|...:       
Mouse   911 IVPKIEDTEIISPVAERPGERSEVDPENHVVVSYCPPIIEEEITNPAADEVGGASQVVYIDVQSM 975

  Fly  1017 -QAEATSEQTAEIWWEPVTSRGKLLGYKIFYTM---TAVED--LDDWQTKTVGLTESADL 1070
             |.:|.:|:..::  :||.    :.|||....:   .||||  .:|.:.||.|....|::
Mouse   976 YQPQAKAEEEQDV--DPVV----VAGYKPQMRLPISPAVEDTAAEDEEGKTAGYRPQANV 1029

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653 12/63 (19%)
Ig 159..228 CDD:299845 12/64 (19%)
I-set 234..318 CDD:254352 10/85 (12%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 6/67 (9%)
fn3 324..404 CDD:278470 16/84 (19%)
FN3 423..514 CDD:238020 28/186 (15%)
FN3 520..610 CDD:238020 24/108 (22%)
FN3 616..707 CDD:238020 23/101 (23%)
FN3 712..810 CDD:238020 15/108 (14%)
FN3 832..907 CDD:238020 19/89 (21%)
FN3 914..1005 CDD:238020 22/130 (17%)
FN3 1012..1101 CDD:238020 18/72 (25%)
fn3 1106..1198 CDD:278470
PTPc 1476..1731 CDD:214550
PTPc 1503..1731 CDD:238006
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
LifrNP_001345522.1 LIFR_N 50..124 CDD:375634 15/119 (13%)
LIFR_D2 126..239 CDD:375455 28/142 (20%)
FN3 428..525 CDD:238020 21/96 (22%)
WSXWS motif 514..518 1/3 (33%)
FN3 547..613 CDD:389787 21/92 (23%)
FN3 724..816 CDD:238020 17/91 (19%)
Box 1 motif 864..872 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1009..1092 7/21 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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