DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and CSF3R

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_724781.1	Gene:	CSF3R / 1441	HGNCID:	2439	Length:	863	Species:	Homo sapiens

Alignment Length:	917	Identity:	188/917 - (20%)
Similarity:	306/917 - (33%)	Gaps:	295/917 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DPPPSIVWRKNGKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDA----PYECVAENGVGDAVS 122
            ||.|.|:||...:.            ||||    |.:.:..|..::    |:....:..:...::
Human    56 DPEPQILWRLGAEL------------QPGG----RQQRLSDGTQESIITLPHLNHTQAFLSCCLN 104

  Fly   123 ADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTV-----LMTCKAI--GNPTPNIYWIKNQTKV 180
            ...:|.|.:..:..||:|     |.     :.|.:     |.|...|  ..|.|       :|.:
Human   105 WGNSLQILDQVELRAGYP-----PA-----IPHNLSCLMNLTTSSLICQWEPGP-------ETHL 152

  Fly   181 DMSNPRYSLKDGFLQIENSREEDQGKYECV--------------------------AENSMGTEH 219
            ..|   ::|| .|....|.:.:.....:||                          |||::||..
Human   153 PTS---FTLK-SFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSM 213

  Fly   220 SKATNL----YVK-----VRRVPPTFSRPPETISEVML-------GSNLNLSCIAVGSPMPHVKW 268
            |....|    .||     :|.:.|:....|.....:.|       |.::|..|     .:.| |.
Human   214 SPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKC-----ELRH-KP 272

  Fly   269 MKGSEDLTPENEMPIGRNVLQLINIQESANYT----CIAASTLGQ----IDSVSVVKVQSLPTAP 325
            .:|.........:|:.....:|..:..:..||    ||.....|.    ..|:.:...:..||..
Human   273 QRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVR 337

  Fly   326 TDV--QISEVTATSVRLEWSYKGPED----LQYYVIQYKPKNANQAFSEISGIITMYYVVRALS- 383
            .|.  :..::...:|:|.|.....|:    :|.||:.::|  :.||     |.|........||
Human   338 LDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRP--SGQA-----GAILPLCNTTELSC 395

  Fly   384 ----PYTEYEFYVIAVNNIGRGPPS--------APATCTTGDFSFGGTKMESAPRNVQVRTLSSS 436
                |....|..::|.|:.|...|:        .||.          |::.:..|:       ..
Human   396 TFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPAL----------TRLHAMARD-------PH 443

  Fly   437 TMVITWEPPET-PNGQVT--GYKVYYTTNSNQPEASWNSQMVDNSELT---TVSELTPHAIYTVR 495
            ::.:.||||.. |.|.|.  |......:|||:   :|  :|..|...|   ....:.|..:|.:.
Human   444 SLWVGWEPPNPWPQGYVIEWGLGPPSASNSNK---TW--RMEQNGRATGFLLKENIRPFQLYEII 503

  Fly   496 VQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWT--KPTHSSENIVHYELYWN 558
            |........|| |..|...:|:..||.........||:|...|:|.  .|......:.||.::|.
Human   504 VTPLYQDTMGP-SQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWT 567

  Fly   559 DTYANQAHHKRI-SNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITA 622
            :. .||:....: ::|..:.|.||.|.:||:|.|.|.||.|
Human   568 NA-QNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAG------------------------ 607

  Fly   623 IATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIW 687
             ||:||.::|..|.|  |.|...||                    |.:..::|         .:.
Human   608 -ATNSTVLTLMTLTP--EGSELHII--------------------LGLFGLLL---------LLT 640

  Fly   688 VLAGTS-VGDGP-RSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIH 750
            .|.||: :...| |.:|:    ...|| ||         :.|...||.|.:.::..|..:|..:
Human   641 CLCGTAWLCCSPNRKNPL----WPSVP-DP---------AHSSLGSWVPTIMEELPGPRQGQWL- 690

  Fly   751 AQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVP 815
             .:..:..:.....|.   |.|..:....|..|.||.::
Human   691 -GQTSEMSRALTPHPC---VQDAFQLPGLGTPPITKLTV-------------------------- 725

  Fly   816 VRPTVSLKIMEREPIVSIELEWERP-----------AQTY---GELRGY----RLRWGVKDQALK 862
                  |:..|::|:     .||..           .|||   |:.|..    :.:.|..||.|.
Human   726 ------LEEDEKKPV-----PWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQVLY 779

  Fly   863 EEMLSGP 869
            .::|..|
Human   780 GQLLGSP 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	14/70 (20%)
		I-set	36..129	CDD:254352	14/70 (20%)
		IG_like	146..227	CDD:214653	22/117 (19%)
		Ig	159..228	CDD:299845	19/100 (19%)
		I-set	234..318	CDD:254352	17/98 (17%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	14/75 (19%)
		fn3	324..404	CDD:278470	20/90 (22%)
		FN3	423..514	CDD:238020	23/96 (24%)
		FN3	520..610	CDD:238020	26/92 (28%)
		FN3	616..707	CDD:238020	19/92 (21%)
		FN3	712..810	CDD:238020	16/97 (16%)
		FN3	832..907	CDD:238020	13/56 (23%)
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470
		PTPc	1476..1731	CDD:214550
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
CSF3R	NP_724781.1	Lep_receptor_Ig	24..110	CDD:283889	13/69 (19%)
		FN3	249..329	CDD:238020	15/85 (18%)
		FN3	345..423	CDD:238020	20/84 (24%)
		fn3	430..514	CDD:278470	22/105 (21%)
		FN3	527..607	CDD:214495	25/80 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910