DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and ptprsa

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_021325154.1	Gene:	ptprsa / 140820	ZFINID:	ZDB-GENE-020107-3	Length:	1945	Species:	Danio rerio

Alignment Length:	2104	Identity:	956/2104 - (45%)
Similarity:	1246/2104 - (59%)	Gaps:	254/2104 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IAALSLLVLS-LLTWTHPTIVDAAHPPEIIRKPQNQ-GVRVGGVASFYCAARGDPPPSIVWRKNG 73
            :.:||.|:|| |||.:.     |...|...:.|.:. ||. |||.||.|.|.|||.|.:.|.|.|
Zfish    10 LLSLSALLLSPLLTGSL-----ALSSPRFTKVPVDMIGVS-GGVVSFVCQATGDPKPKVTWNKKG 68

  Fly    74 KKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAG 138
            |:|: :|...|:....|..::|||:|:||.||:..|||.|||..|: ::..|.|:|...|..|.|
Zfish    69 KRVN-SQRIETIEFDEGAGAVLRIQPLRAPRDENVYECQAENSEGE-INVQAKLSIIREDLLPPG 131

  Fly   139 FPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKD------------ 191
            ||.|..||..:|:|...|..|.|.|.|||.|.|.|.|:...:|.:.....:|.
Zfish   132 FPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPIDPNTSNGRIKQLRSEAFEGTPIR 196

  Fly   192 GFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVK----VRRVPPTFSRPPETISEVMLGSNL 252
            |.|||||:.|.|||||||||.|..|..:|...||||:    ||||||.||..| |..|:|.|.::
Zfish   197 GALQIENTEETDQGKYECVASNVEGVRYSSPANLYVRELREVRRVPPRFSILP-TSQEIMPGGSV 260

  Fly   253 NLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVK 317
            |::|:|||||||:||||..|||||||:|||:|||||:|.:::|||||||:|.|:||.|::|:.:.
Zfish   261 NITCVAVGSPMPYVKWMLNSEDLTPEDEMPVGRNVLELNSVRESANYTCVAMSSLGIIETVAQIT 325

  Fly   318 VQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRAL 382
            |:|||..|....::|.||||:.:.|....||.:.:|:|||:.|:....|..:..|.|..|.:..|
Zfish   326 VKSLPKPPGTPVVTETTATSITITWDSGNPEPVSHYIIQYRAKSPESKFETVDSITTTRYSIGGL 390

  Fly   383 SPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPET 447
            ||.|:||..|.|.|.||:||||.|....||:     ....|.|||:|.|.:|.:|:::.|:.|:.
Zfish   391 SPNTDYEIRVSAFNTIGQGPPSEPVEARTGE-----QAPASPPRNIQARIISQNTVLVRWDEPDE 450

  Fly   448 PNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQ 512
            ||||:.||:||||.:...|.:.|....|.:|.|||:..|.....||:||.|:||:|.||.|.|:.
Zfish   451 PNGQIKGYRVYYTMDPTLPMSMWQIHNVQDSVLTTIQSLVTSETYTIRVLAFTSVGDGPFSDPIH 515

  Fly   513 VKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYT 577
            ||..||||.||:||:..::.:|.|.|.| :|....|.|:.|||::.:........|:.:.:.::.
Zfish   516 VKVLQGVPGQPTNFQVGEVSDTGVELTW-EPAFEKEGIISYELHYKEGKDGPLGKKKFAPTSSFV 579

  Fly   578 LDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTISLSWLPPPVE 640
            :|||.|:|.|:..|||.|.:|.||.|..:...|.|.  .|||::|...::|||.:.:||.|||.|
Zfish   580 VDGLRPNTEYFFSLAAVSSKGIGAFTNDLAQTTSQAKPSAPPQDIKCSSSSSTVLMVSWRPPPAE 644

  Fly   641 RSNGRIIYYKVFFVEVGREDDEATTMTLNMTS--IVLDELKRWTEYKIWVLAGTSVGDGPRSHPI 703
            ..||.:..|.|.:..||...:.:|......||  |:|..|::||.|::.|.|.||||.||.|.|:
Zfish   645 SQNGELAGYIVRYAVVGAGAEVSTEHVEAPTSDQILLQRLEKWTMYRVTVAASTSVGSGPESEPL 709

  Fly   704 ILRTQEDVPG-DPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRD-EGKGFLNEPF 766
            :.||.||||| .|:.|:...||||:|.|.|:..|...::|.||||.:|...:.: |.:|.   |.
Zfish   710 LCRTDEDVPGAPPRRVEVEVLNSTAIKVMWRSLLPGKQHGQIRGYQVHYVRVENGESRGL---PL 771

  Fly   767 KFDVV---------DTLEFN--VTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTV 820
            ..||:         ||.|:.  :.||||||.|||.|||.|.||||.||...:|.|.|.||..|.:
Zfish   772 IKDVMLADAQWEMDDTAEYEMVIGGLQPDTTYSITVAAYTTKGDGARSKPKLVLTKGAVPGPPFL 836

  Fly   821 SLKIMEREPIVSIELEWERPAQTYG--ELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGV 883
            |:........:   :.|:.|.....  |::||||::|.||......:..|||..:....|:.||.
Zfish   837 SVNQNSESTAI---IRWQPPDYVAPGLEVQGYRLQFGRKDVNPLATLEFGPQELEYSISNIHRGA 898

  Fly   884 EYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPP-----SNIT---IRFQTPDVLCVTWDPPTREH 940
            .|.|:|:..:..|.|:|..:..:.||..|.|.|     ||||   ::|        :|.||....
Zfish   899 TYIFKVSAKSKSGFGEEATQELRVPEEVPRGYPQITEGSNITCCSVQF--------SWLPPVLAE 955

  Fly   941 RNGIITRYDVQFHKKIDHGLGSERNMTL----RKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKL 1001
            |||.||.|.:.:.:.  ..:...:.:.|    ...:..:|..|..|..::||:|..|.||:|
Zfish   956 RNGAITEYTLSYQEA--GTISGPKELRLPADENSYILNSLRPNAVYDVKIRAHTSVGPGPYS--- 1015

  Fly  1002 IVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTE 1066
                                         .|:..|
Zfish  1016 -----------------------------PPIQYR------------------------------ 1021

  Fly  1067 SADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRL 1131
                         .||..|                    |||.|.....|:..::.|||......
Zfish  1022 -------------TVAYEA--------------------DVPRNFTVKLVTKTTVLLSWKFYDSR 1053

  Fly  1132 TPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSY 1196
            .|....|.:...|..:|::                 ..|| .|..|.|.|||...:|...|. ..
Zfish  1054 FPYKCTIEYHRQKSDIDAR-----------------MTKT-LITNLRPNTTYEFRISCQDSS-DG 1099

  Fly  1197 RPPTKITVTTQMAAPQPMV-KPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSN---L 1257
            .|..|:...|   ||...: ||:.......|..|.|:....|....|...|:||||..|..   .
Zfish  1100 GPKHKLVART---APHIQIRKPELDLKRESESTLTIVFPPLETKDLIKAIYVVVVPLKKGKGPMR 1161

  Fly  1258 H-KIPDQFLTDDLLPGRN------------KPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFT 1309
            | |.||:...::||..|.            |......|||||.|...|:|.:|.||:...|.:|.
Zfish  1162 HIKSPDELDLEELLGERRLGLHHSGTTRQLKQVDGKRPYIAASFKPSSMPPSFTLGNQMMYGSFE 1226

  Fly  1310 NRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSE-FLSLDMREAPPGERPHRPDPNWPAEPEVSVN 1373
            ||.|:|.:.|.:|:.|.::|.....:.|||::: .::.|:            ||. |.|
Zfish  1227 NRALDRGQEYVLFILAELNTTGVKAFVSSPYTDPIMAPDL------------DPQ-PLE------ 1272

  Fly  1374 RNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLM-AADLGAGPTPSD 1437
              .....::|||.|::...||:...:.:|.....:....|..:....|:.|: .||: ....|:|
Zfish  1273 --SGGDGLIWVVGPVLAVVFIICIVIAILLYKNSKPDSSKRKESEPRTKCLLNNADI-TPHHPTD 1334

  Fly  1438 PVDMRRLNFQTP----------------GMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEP 1486
            ||:|||:|||||                .|::||||||||.|.|.|.||:|||.|.|||||||:|
Zfish  1335 PVEMRRINFQTPDSGLSSPVSEAGFDYESMMNHPPIPISELAEHTELLKANDNLKLSQEYESIDP 1399

  Fly  1487 GQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGP 1551
            ||||||::||||.||.|||||||.|||||||.|..:||:.||||||:||.|||||.|||:|||||
Zfish  1400 GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILAPIEGITGSDYINSNYIDGYRKQNAYIATQGP 1464

  Fly  1552 LQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIR 1616
            |.|||.|||||.||.:.||:||||||||::|||||||||:|||||||.|.||:.:|.||||:.:|
Zfish  1465 LPETFGDFWRMVWEQRAATVVMMTRLEEKSRIKCDQYWPSRGTETYGMIQVTLLDTIELATFCVR 1529

  Fly  1617 TFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTG 1681
            ||.|.:.|.:::||::|.|||||||||||::|.|||.||||.:...||::||:|.||||||||||
Zfish  1530 TFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIIAHCSAGVGRTG 1594

  Fly  1682 CYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLH 1746
            |:||||:||||:||||.:|||||||.:|:||||||||||||.|||||:|||:.||.|||.||:|.
Zfish  1595 CFIVIDAMLERIKHEKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEAVACGNTEVAARSLF 1659

  Fly  1747 THLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPI 1811
            :::|||...|.||.:||||:|||:|:|.|..:|:|::|||||||.|||||:|:|||::||.|.||
Zfish  1660 SYIQKLAQVEAGEHVSGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYETTRVCLQPI 1724

  Fly  1812 HGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQ 1876
            .|:|||||:|:|||||||.:.||||.|||:.:..|||||||||:|||||||||||:|||||||.|
Zfish  1725 RGLEGSDYINSSFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ 1789

  Fly  1877 YWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFI 1941
            |||.|||.||||:||||:||||||||.||||||||||||.|||||||||.|||||||||||||||
Zfish  1790 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFI 1854

  Fly  1942 DFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAM 2006
            |||||||||||||||||||:|||||||||:|||||||||||||:||||:|:||||::||:|||||
Zfish  1855 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAM 1919

  Fly  2007 VQTEDQYHFCYRAALEYLGSFDNY 2030
            |||||:|.|||:||||||||||:|
Zfish  1920 VQTEDEYQFCYQAALEYLGSFDHY 1943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	40/94 (43%)
		I-set	36..129	CDD:254352	40/93 (43%)
		IG_like	146..227	CDD:214653	37/92 (40%)
		Ig	159..228	CDD:299845	34/80 (43%)
		I-set	234..318	CDD:254352	50/83 (60%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	43/67 (64%)
		fn3	324..404	CDD:278470	31/79 (39%)
		FN3	423..514	CDD:238020	40/90 (44%)
		FN3	520..610	CDD:238020	30/89 (34%)
		FN3	616..707	CDD:238020	37/92 (40%)
		FN3	712..810	CDD:238020	46/110 (42%)
		FN3	832..907	CDD:238020	22/76 (29%)
		FN3	914..1005	CDD:238020	27/102 (26%)
		FN3	1012..1101	CDD:238020	5/88 (6%)
		fn3	1106..1198	CDD:278470	22/91 (24%)
		PTPc	1476..1731	CDD:214550	184/254 (72%)
		PTPc	1503..1731	CDD:238006	163/227 (72%)
		PTPc	1763..2022	CDD:214550	207/258 (80%)
		PTPc	1791..2022	CDD:238006	189/230 (82%)
ptprsa	XP_021325154.1	I-set	31..122	CDD:254352	40/93 (43%)
		Ig2_RPTP_IIa_LAR_like	150..233	CDD:319301	34/82 (41%)
		Ig3_RPTP_IIa_LAR_like	257..325	CDD:143216	43/67 (64%)
		FN3	330..419	CDD:238020	35/88 (40%)
		FN3	426..518	CDD:238020	41/91 (45%)
		FN3	523..612	CDD:238020	30/89 (34%)
		FN3	620..713	CDD:238020	37/92 (40%)
		fn3	721..819	CDD:306538	41/100 (41%)
		FN3	831..919	CDD:238020	25/90 (28%)
		fn3	931..1015	CDD:306538	25/93 (27%)
		FN3	1028..1101	CDD:238020	22/91 (24%)
		PTPc	1415..1644	CDD:238006	163/228 (71%)
		PTPc	1676..1935	CDD:214550	207/258 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	418	1.000	Domainoid score	I627
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1236	1.000	Inparanoid score	I178
OMA	1	1.010	-	-		QHG47937
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	1	1.000	-	-		otm25136
orthoMCL	1	0.900	-	-		OOG6_100623
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760