DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and IL31RA

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_620586.3	Gene:	IL31RA / 133396	HGNCID:	18969	Length:	764	Species:	Homo sapiens

Alignment Length:	922	Identity:	174/922 - (18%)
Similarity:	290/922 - (31%)	Gaps:	335/922 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 TQGPGTRVIEVGHTVLMTCKAIG----NPTPNIYWIKNQTKVDMSNPRYSLKDGF-LQIENSREE 202
            |..||.......:||..| .|.|    |.|.|....:|:.......||.::.|.: :::|
Human    73 TWSPGKETSYTQYTVKRT-YAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVE----- 131

  Fly   203 DQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETIS-EVMLGSNLNLSCIAVGSPMPHV 266
                    |||..|...|..|  |.::..:..|  .||:... :.:||.          ..|..:
Human   132 --------AENGDGVIKSHMT--YWRLENIAKT--EPPKIFRVKPVLGI----------KRMIQI 174

  Fly   267 KWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQIS 331
            :|:|      ||           |..:.....||                           ::..
Human   175 EWIK------PE-----------LAPVSSDLKYT---------------------------LRFR 195

  Fly   332 EVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVN 396
            .|.:||    |....      :....|.||..             |.:..|.|:||   ||||:.
Human   196 TVNSTS----WMEVN------FAKNRKDKNQT-------------YNLTGLQPFTE---YVIALR 234

  Fly   397 NIGRGPPSAPATCTTGDFSFG--------GTKMESAPRNVQV-RTLSSS------TMVITWEPPE 446
                        |...:..|.        |...|.||..::: |.|..:      .:.:.|:...
Human   235 ------------CAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKAR 287

  Fly   447 -TPNGQVT-GYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPH---AIYTVRVQAYTSMGAGP 506
             .|..:.| ||.::|     .||::.|.....|   ||..:|..|   ..:.|.:.:|.|:|..|
Human   288 GAPVLEKTLGYNIWY-----YPESNTNLTETMN---TTNQQLELHLGGESFWVSMISYNSLGKSP 344

  Fly   507 MSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRIS 571
            ::| :::.|.|....|........:.|..:.::|..   |:.::..:.:.|
Human   345 VAT-LRIPAIQEKSFQCIEVMQACVAEDQLVVKWQS---SALDVNTWMIEW-------------- 391

  Fly   572 NSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLP 636
                      :||                                        ..|...:|||
Human   392 ----------FPD----------------------------------------VDSEPTTLSW-- 404

  Fly   637 PPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWV--LAGTSVGDGPR 699
                                     |:.:...|.| |..|:||.:..|.|.|  :....||:
Human   405 -------------------------ESVSQATNWT-IQQDKLKPFWCYNISVYPMLHDKVGE--- 440

  Fly   700 SHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGF--- 761
            .:.|....:|.||.:..:.|...:...::.::||...:.:|.|||..|.|..|  .:.||||
Human   441 PYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQ--AEGGKGFSKT 503

  Fly   762 LNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKT---------------P 811
            :|.       ..|::.:..|:..|.|.:||.|.|..| |....:|..||               .
Human   504 VNS-------SILQYGLESLKRKTSYIVQVMASTSAG-GTNGTSINFKTLSFSVFEIILITSLIG 560

  Fly   812 GGVPVRPTVSLKIMEREPIVSIELEW---ERPAQT-----YGELRGYRLRWGVK---DQALKEEM 865
            ||:.:...:::....::|.....|.|   ..||::     :|:  .::.:..:|   |....|:.
Human   561 GGLLILIILTVAYGLKKPNKLTHLCWPTVPNPAESSIATWHGD--DFKDKLNLKESDDSVNTEDR 623

  Fly   866 LSGPQMTKK----------RFDN-LERGVEYEFRVAGSNHIG----------------IGQETVK 903
            :..|..|..          .|.| |:.....|.|....|::|                :|:...:
Human   624 ILKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEARTGQENNLGGEKNGYVTCPFRPDCPLGKSFEE 688

  Fly   904 I---------------FQTPEGTPGGPPSNITIRFQ----TPDVLCVTWDPPTREHRNGIITRYD 949
            :               .:.||||  .|.:...:.|.    .||.||.. ..|....:|.:..|..
Human   689 LPVSPEIPPRKSQYLRSRMPEGT--RPEAKEQLLFSGQSLVPDHLCEE-GAPNPYLKNSVTAREF 750

  Fly   950 VQFHKKIDHGLG 961
            :...|..:|..|
Human   751 LVSEKLPEHTKG 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653	21/85 (25%)
		Ig	159..228	CDD:299845	18/73 (25%)
		I-set	234..318	CDD:254352	13/84 (15%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	9/67 (13%)
		fn3	324..404	CDD:278470	16/79 (20%)
		FN3	423..514	CDD:238020	24/102 (24%)
		FN3	520..610	CDD:238020	7/89 (8%)
		FN3	616..707	CDD:238020	17/92 (18%)
		FN3	712..810	CDD:238020	27/100 (27%)
		FN3	832..907	CDD:238020	18/127 (14%)
		FN3	914..1005	CDD:238020	12/52 (23%)
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470
		PTPc	1476..1731	CDD:214550
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
IL31RA	NP_620586.3	FN3	57..151	CDD:304408	23/93 (25%)
		FN3	155..254	CDD:238020	31/190 (16%)
		FN3	453..533	CDD:214495	24/88 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910