Protein Alignment Lar and Ptp52F

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: XP_061510830.1
• Gene: Ptp52F / 1280988
• VectorBaseID: AGAMI1_010367
• Length: 1478
• Species: Anopheles gambiae
• Alignment Length: 1661
• Identity: 357/1661 - (21%)
• Similarity: 588/1661 - (35%)
• Gaps: 494/1661 - (29%)

  Fly   284 GRNVLQLINIQESA-NYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGP 347
            ||:|   .|.:.|| ..:.:.:.|...::.:. :::......|.::.||. :..:|. |||.:..
Mosquito    24 GRDV---YNDENSALRLSALPSQTFNDLNELD-LRISHCRLKPLNITISR-SVVNVE-EWSDERD 82

  Fly   348 EDLQYYV-IQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTT 411
            :::.|:: :|:...||..:.:.    :|.:.:.....|..:                    .|:.
Mosquito    83 DNVFYHLEVQWIQPNATVSTAN----LTAWLMQNIALPVRD--------------------QCSL 123

  Fly   412 GDFSFGGTKMESAPRNVQVRTLSSSTMVIT---WEPPETPNGQVTGYKVYYTTNSNQPEA-SW-- 470
                   .|:::..|:::       |.|..   |||   ..|::|..:|....|.|...| :|
Mosquito   124 -------LKLKACQRDLR-------TPVCVCGEWEP---QCGKITDIEVMEVGNDNPTYALTWKV 171

  Fly   471 -NSQMVDNSELTTVSELTPHAI-------------YTVRVQAYTSMGAGP--------MSTPVQ- 512
             :...|...||...|.:.|..|             |.| |.....:.||.        :.:||:
Mosquito   172 EDQACVHRYELLVGSSVIPLDIPFVGMSGLQGGKKYRV-VLKIICINAGKVQHLLEIYVKSPVKQ 235

  Fly   513 -------------VKAQQG----VPSQPSNFRATDIGETAVTLQ----------WTKPTHSSENI 550
                         |:.:.|    :...|..|:...|.....|.:          :...||...::
Mosquito   236 TTPNPWRCGLEFYVQHRNGIGEVINDNPKTFQFYHIARPITTRKVCSKEARKESYKTKTHGKLSV 300

  Fly   551 VHYELYWN-------------DTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGAT 602
            .......|             |.:|..:|.:..||:....|..:.|   ....|.|||..|:...
Mosquito   301 SDTNFQPNRVPVDVSTPQLPLDYFAKTSHIELPSNAIPKVLSAIPP---LCPGLRARSSSGDAII 362

  Fly   603 TPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMT 667
            .|       |...|.|::.|......::.|||.||    ..|.:. .|.:.:   ....|:.|:.
Mosquito   363 KP-------QTVGPVRDLRANTDLDRSVLLSWRPP----KEGAVC-VKEYLI---TWSSESATID 412

  Fly   668 LNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKAT----------- 721
            .:.|...:..|:....|:..|.|.....|               .|.|:.:.||
Mosquito   413 ASRTVYNVTNLEPCMTYEFTVNAIDHTND---------------KGTPESISATVRELQQLSQVT 462

  Fly   722 --PLNST---SIHVSWKPPLEKDRNG--IIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVT 779
              .||..   |:.|.||||    .||  .:..|.:.|         :.|.|.....|..:..|.|
Mosquito   463 ELELNEVEPRSLSVKWKPP----TNGTFCVESYRVVA---------WYNNPANSADVTEVFSNTT 514

  Fly   780 GLQPDT--------KYSIQVAALT-RKGDGDRSAAIVVKTPGGVPVRPTVSLKIMER-------E 828
            ..|..|        .|::||..:: .|.||               :....::|..||       |
Mosquito   515 TDQHVTFGEVIACMSYTVQVIPISISKHDG---------------LNEIGTIKTKERTILFYHVE 564

  Fly   829 PIVSIEL---EWERPAQTYGE-----------LRGYRLRWGV---KDQALKEEMLSGPQMTKKRF 876
            ||.:|.|   ..|.....:.|           ....::..||   :.|.:||.::.....|   |
Mosquito   565 PIRAIALSSRSLELSTMLHSENNNNCLLVTVAFNCTKMVEGVPVPESQVIKEFVIPNGNTT---F 626

  Fly   877 DNLERGVE-------YEFRVAGSNHIGIGQET-VKIFQTPEGTPGGPPSNITIRFQTPDV----- 928
            :.:   ||       ||......|..|....| ...|.|.|..|           ::|.|
Mosquito   627 EGI---VEPLVPYSTYECNAKIQNIAGWSDPTPAYTFVTAEDVP-----------ESPSVIELIG 677

  Fly   929 ----LCVTWDPPTREHRNGIITRYDV-------------------QFHKKIDHGLGSERNMTLRK 970
                :.:.|..||  .:||::.||.:                   :|::.:|  |..|.|....:
Mosquito   678 KNRSIGIIWKAPT--VKNGVVVRYRIHVRMVAPEYPLPKLCAPLEEFNETVD--LRDEVNPDESR 738

  Fly   971 A--------VFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQ------AEAT 1021
            :        |...|...|.|:.:|.|.|..|.||:::.:.|.|..|:.....|.:      .|..
Mosquito   739 SWDGIEFEHVVAKLNPYTLYLVQVAAATGAGFGPYTEPVEVVTLPDVSNVTASFRIDKIEGPELN 803

  Fly  1022 SEQTAEIW--WE-PVTSRGKLLGYKIFY-TMTAVEDLD-------DWQTKTVGLTESADLVNLEK 1075
            ....:.:|  |: |....|:|   |.|. .|..:.:.|       .|:   |.:.|..:::::..
Mosquito   804 QTYKSSVWFGWDLPCGLNGRL---KRFVGEMYGIREQDPSNPHALTWE---VNVGEEEEILDVYS 862

  Fly  1076 FAQ--------YAVAIAARFKNGLGRLSEKVTVRIK-PEDVPLNLRAHDVSTHSMTLSWSPPIRL 1131
            :.:        |.|||..... .:..||::|.|:.: |..:|
Mosquito   863 YVEDRLKPEYNYTVAIRVEVV-AVEELSDEVKVQFESPAGIP----------------------- 903

  Fly  1132 TPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSY 1196
                   |.|..:.:.:...|..........|:|.:...|..|..:....
Mosquito   904 -------SIDQKEEWFNVDVFEAPNPTNTARIMLGNITLTSDIGSIRYMA--------------- 946

  Fly  1197 RPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIP 1261
                 :.|:.::..|.|..:.||.....|           .::..:..:||       :|..:..
Mosquito   947 -----LLVSERLCQPDPTPRTDFINSTGG-----------TQWPSVPDWYL-------ANEKRCA 988

  Fly  1262 DQFLT-----DDLLPG-RNKPERPNA---PYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREK 1317
            :|:.|     :.:..| |...:|..|   .|:..|            ...|....:.|..|:...
Mosquito   989 EQYQTTPKFWNPMARGQRATTDREAAGLIEYVIGK------------EDCDRGQEYCNGPLKPGT 1041

  Fly  1318 RYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEIL 1382
            .|.:.||..    .:..||.|....|.:                     :..:.|..      |:
Mosquito  1042 EYALIVRIF----SRSGYTDSEMQVFRT---------------------DSLIKVGL------IV 1075

  Fly  1383 WVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQ 1447
            ..||..:|..|:..     |.||.|::            |.|:.|....|....:|.|
Mosquito  1076 SAVLACLVLAFLGG-----LFVVWRKQ------------RLLLPAQQTRGAPTEEPAD------- 1116

  Fly  1448 TPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNS----NLEHNKSKNRYAN 1508
                     ||:..|.:..:.|..::.:|.|:|:::|.....|...::    :...|:.||||.|
Mosquito  1117 ---------IPVKNFPHQYDELFQSNREKVSKEFQAINYFSDFALQDTVSFQSARENERKNRYVN 1172

  Fly  1509 VTAYDHSRVQLPA----VEGVVG-SDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKT 1568
            :..||.:||.|.:    .||..| :|||||::.:||:....|:|||||.|||..|||||..:.:.
Mosquito  1173 ILPYDSNRVLLDSNEDGEEGEYGANDYINASFIEGYKYQREYIATQGPKQETCADFWRMVLQYEI 1237

  Fly  1569 ATIVMMTRLEERTRIKCDQYWPTRGTET-YGQIFVTITETQELATYSIRTFQLCRQGFNDRREIK 1632
            .:|||:|:..:..:.||.||:|.....| ||.|.|..|:...|:.|..|.| |..:| |..:.:.
Mosquito  1238 ESIVMLTQPIDHDKNKCCQYFPRFDQYTDYGDIRVKCTQELNLSLYYKRLF-LVSKG-NLTKAVF 1300

  Fly  1633 QLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEK 1697
            ...|..||||..|...|..::|.:..||.....:.|::|||||||||||.:|.:|.:|:|::.||
Mosquito  1301 HYHFLEWPDHSCPASTADLIKFSKIVRAERKSYAIPLVVHCSAGVGRTGTFIALDIVLQRLQQEK 1365

  Fly  1698 IIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI 1733
            .|::|..|..||.||..||||.|||.|::...:|.:
Mosquito  1366 KINVYDTVKQLRRQRVKMVQTLDQYTFLYQCCMEYV 1401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401	7/35 (20%)
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401	1/4 (25%)
		Ig strand F	298..305	CDD:409401	0/6 (0%)
		Ig strand G	309..318	CDD:409401	0/8 (0%)
		FN3	322..411	CDD:238020	14/89 (16%)
		FN3	<382..747	CDD:442628	84/451 (19%)
		FN3	712..810	CDD:238020	29/124 (23%)
		FN3	832..898	CDD:214495	17/89 (19%)
		FN3	<867..1269	CDD:442628	82/476 (17%)
		fn3	914..998	CDD:394996	24/119 (20%)
		R-PTPc-LAR-1	1498..1735	CDD:350401	101/242 (42%)
		R-PTP-LAR-2	1784..2021	CDD:350402
Ptp52F	XP_061510830.1	None