Protein Alignment Lar and Lar

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: XP_061516302.1
• Gene: Lar / 1279520
• VectorBaseID: AGAMI1_014585
• Length: 2049
• Species: Anopheles gambiae
• Alignment Length: 2050
• Identity: 1642/2050 - (80%)
• Similarity: 1838/2050 - (89%)
• Gaps: 23/2050 - (1%)

  Fly     1 MGL---QMTAARPIAALSLLVL-----SLLTWTHPTIVD-----AAHPPEIIRKPQNQGVRVGGV 52
            |||   ..|||..:|.::.|.|     .::..:|....|     ..||||||:||.|||||||||
Mosquito     1 MGLLVVNSTAALLLAIIATLFLLAEVPQIVVASHGNFSDFPFIYLTHPPEIIKKPVNQGVRVGGV 65

  Fly    53 ASFYCAARGDPPPSIVWRKNGKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGV 117
            |:|:|||||||.|:::||||.||:..|||||||.: ..|:|:|||||||||||||||||||||||
Mosquito    66 ATFFCAARGDPQPTVIWRKNSKKIMMTQSRYTVYD-ANGVSMLRIEPVRAGRDDAPYECVAENGV 129

  Fly   118 GDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDM 182
            ||||||:||||:|||||||||||||.|.|..||||.|||.:|.|||.|:|.|.|||:|:..:|||
Mosquito   130 GDAVSAEATLTVYEGDKTPAGFPVIKQFPTIRVIETGHTAVMQCKATGSPPPKIYWLKDMKRVDM 194

  Fly   183 SNPRYSL-KDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEV 246
            :|||||: .:|.|||:||.|.|.||||||||||:||||:|.|.|||||||||||||||||.:.||
Mosquito   195 TNPRYSINSEGSLQIDNSEESDMGKYECVAENSIGTEHTKPTPLYVKVRRVPPTFSRPPEPVYEV 259

  Fly   247 MLGSNLNLSCIAVGSPMPHVKWMKG-SEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQI 310
            |||:||.|:|:|||||||.|||.|| .:||||||::|:|||||:|.:|:.|.||||||.|:||.|
Mosquito   260 MLGANLTLTCVAVGSPMPSVKWRKGVDQDLTPENDVPVGRNVLELTDIRVSTNYTCIAQSSLGVI 324

  Fly   311 DSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITM 375
            ::.|:|||||||.|||||.|||||||.||||||||||||||||||||||||||||||||||||||
Mosquito   325 EATSLVKVQSLPAAPTDVTISEVTATQVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITM 389

  Fly   376 YYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCT---TGDFSFGGTKMESAPRNVQVRTLSSST 437
            :||||.|||||||||||||||||||||||.|||.|   |||.::||:||||||||::|:.|||||
Mosquito   390 FYVVRTLSPYTEYEFYVIAVNNIGRGPPSLPATTTTGETGDSAYGGSKMESAPRNIEVKPLSSST 454

  Fly   438 MVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSM 502
            |:|||||||||||||||||||||||.|||||||:||| :.:::||:||||||||||:||||:|||
Mosquito   455 MLITWEPPETPNGQVTGYKVYYTTNPNQPEASWDSQM-ETNDMTTISELTPHAIYTIRVQAFTSM 518

  Fly   503 GAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHH 567
            ||||:|.|||||||||||||||||||||:|||||||||::||||.||||||||||||||||:.||
Mosquito   519 GAGPLSNPVQVKAQQGVPSQPSNFRATDVGETAVTLQWSRPTHSGENIVHYELYWNDTYANEQHH 583

  Fly   568 KRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTI 630
            :||.|:|.|||..||||||||.||:|||||||||||||||||||||  ||||||:|..|||.|||
Mosquito   584 QRIPNTETYTLSSLYPDTLYYFWLSARSQRGEGATTPPIPVRTKQYVPGAPPRNVTVEATSPTTI 648

  Fly   631 SLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVG 695
            ::||||||||||||.|:|||||||||||.|.|||..|||.|||||||||||||||||||||||||
Mosquito   649 NVSWLPPPVERSNGAIVYYKVFFVEVGRSDSEATVTTLNSTSIVLDELKRWTEYKIWVLAGTSVG 713

  Fly   696 DGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKG 760
            |||||:|..:||.||||||||||||:|:|||:|:|:||||.||:|||||||||||.||:::||||
Mosquito   714 DGPRSYPYTVRTHEDVPGDPQDVKASPVNSTTIYVTWKPPKEKNRNGIIRGYHIHVQEMKEEGKG 778

  Fly   761 FLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIM 825
            .||||.||||||.||:||||||||||||:|||||||||||||||.|.||||||||:||||:|||:
Mosquito   779 LLNEPMKFDVVDGLEYNVTGLQPDTKYSVQVAALTRKGDGDRSAPISVKTPGGVPIRPTVTLKIL 843

  Fly   826 EREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVA 890
            ||:|.||||||||||.||||||||||:||||::|||.||:|.|.|:..||.::||||||||||||
Mosquito   844 ERDPTVSIELEWERPRQTYGELRGYRVRWGVREQALNEEILQGTQLNVKRINDLERGVEYEFRVA 908

  Fly   891 GSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKK 955
            |.||||||||.||..|||||:|.|||:.|.:|||||||:|:||:|||||||||.|||||||||||
Mosquito   909 GMNHIGIGQEAVKHLQTPEGSPTGPPTGIAVRFQTPDVVCITWEPPTREHRNGQITRYDVQFHKK 973

  Fly   956 IDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEA 1020
            ||||||:|||.|:||||||||:|:||||.||||||||||||||:|:::.|||||||||.|:||.|
Mosquito   974 IDHGLGTERNTTVRKAVFTNLDESTEYIVRVRAYTKQGAGPFSEKVVIATERDMGRAPFSVQAVA 1038

  Fly  1021 TSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAA 1085
            |||||.|:|||||.|||||:|||||||||||||||:||||.||:||||||:||||||||||||||
Mosquito  1039 TSEQTVEVWWEPVPSRGKLVGYKIFYTMTAVEDLDEWQTKVVGVTESADLINLEKFAQYAVAIAA 1103

  Fly  1086 RFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQ 1150
            .:|.|||:||||.||::|||||||||||||||||||||||:||||:.|:||||||||:|.|||||
Mosquito  1104 MYKTGLGKLSEKATVKVKPEDVPLNLRAHDVSTHSMTLSWAPPIRMNPINYKISFDAVKEFVDSQ 1168

  Fly  1151 GFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMV 1215
            |.||.||:|::|||||.:||:|||:||||||||.|||||:|:||||:||.|||||||||||||||
Mosquito  1169 GISQKQILPRKEIILKSHVKSHTISELSPFTTYFVNVSAVPTDYSYKPPAKITVTTQMAAPQPMV 1233

  Fly  1216 KPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKPERPN 1280
            :||||||||||||.||||||||||||||||||:||||||:|||||||||||::|||.|.|.:|.|
Mosquito  1234 QPDFYGVVNGEEIQVILPQASEEYGPISHYYLIVVPEDKANLHKIPDQFLTEELLPSRPKLDRLN 1298

  Fly  1281 APYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLS 1345
            ||||||.|.||:||:|||||||:..|||||:||||.||||||||||||||||||||||||||||:
Mosquito  1299 APYIAAMFLQRNIPYTFHLGSGETNHNFTNKKLERGKRYRIFVRAVVDTPQKHLYTSSPFSEFLA 1363

  Fly  1346 LDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQ 1410
            |||:|||.||.||||:||.|.:.|:.:....:||.:||||.|: ::..::|...:|:..|:||||
Mosquito  1364 LDMKEAPTGEPPHRPNPNVPQDTEIIIRGKNEEPGMLWVVGPI-IAALVLSVCFLVVYFVRRRRQ 1427

  Fly  1411 PCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQ 1475
            |||.|||||||||||||||||||.|:|||||||:|||||||||||||.|:|.|||:||||:|||.
Mosquito  1428 PCKAPDQAAVTRPLMAADLGAGPAPTDPVDMRRINFQTPGMISHPPISIAELANHVERLKANDNL 1492

  Fly  1476 KFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYR 1540
            ||||||||||||||||||:||:|.||.||||||||:||||||.||.:|||.||||||||||||||
Mosquito  1493 KFSQEYESIEPGQQFTWDHSNMEVNKPKNRYANVTSYDHSRVILPPIEGVPGSDYINANYCDGYR 1557

  Fly  1541 KHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTIT 1605
            ||||||||||||||||.||||||||||::|||||||||||:|||||.|||.||||.||.:.||||
Mosquito  1558 KHNAYVATQGPLQETFGDFWRMCWELKSSTIVMMTRLEERSRIKCDMYWPARGTEVYGAMTVTIT 1622

  Fly  1606 ETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVI 1670
            ||||||||||||||:.|.|.|:||||||||||||||||||||||||||||||.::|||.||||:|
Mosquito  1623 ETQELATYSIRTFQIYRNGSNERREIKQLQFTAWPDHGVPDHPAPFLQFLRRTKSLTPSESGPII 1687

  Fly  1671 VHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIIC 1735
            ||||||||||||||||||||||||:||.||||||||||||||||||||||||||||||:|||:||
Mosquito  1688 VHCSAGVGRTGCYIVIDSMLERMKYEKTIDIYGHVTCLRAQRNYMVQTEDQYIFIHDALLEAVIC 1752

  Fly  1736 GVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILP 1800
            |.||||||:||.|:|||:.|||.|.|:|||:|:|||||||.||::||||||||||||||||||||
Mosquito  1753 GSTEVPARSLHNHIQKLMQTEPHENITGMEMEYKKLSNVKADSTRFVTANLPCNKHKNRLVHILP 1817

  Fly  1801 YESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTK 1865
            ||||||.||||.|:|||||:|||.:||||||:||||||||:|:.|||||||||||||||||||||
Mosquito  1818 YESSRVCLTPIRGVEGSDYINASLVDGYRYRNAYIAAQGPLQETAEDFWRMLWEHNSTIVVMLTK 1882

  Fly  1866 LKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPE 1930
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
Mosquito  1883 LKEMGREKCFQYWPHERSVRYQCYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPE 1947

  Fly  1931 QGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQT 1995
            ||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
Mosquito  1948 QGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMQYEGVLDVFQT 2012

  Fly  1996 VRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNY 2030
            ||||||||||||||||||.||||||||||||||:|
Mosquito  2013 VRILRSQRPAMVQTEDQYQFCYRAALEYLGSFDHY 2047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151	72/92 (78%)
		Ig strand B	53..57	CDD:409353	2/3 (67%)
		Ig strand C	66..70	CDD:409353	0/3 (0%)
		Ig strand E	93..97	CDD:409353	2/3 (67%)
		Ig strand F	108..113	CDD:409353	4/4 (100%)
		Ig strand G	122..125	CDD:409353	2/2 (100%)
		Ig	141..228	CDD:472250	56/87 (64%)
		Ig strand B	157..161	CDD:409353	1/3 (33%)
		Ig strand C	170..174	CDD:409353	2/3 (67%)
		Ig strand E	192..196	CDD:409353	2/3 (67%)
		Ig strand F	206..211	CDD:409353	4/4 (100%)
		Ig strand G	218..221	CDD:409353	2/2 (100%)
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401	54/82 (66%)
		Ig strand A	237..239	CDD:409401	1/1 (100%)
		Ig strand A'	244..248	CDD:409401	2/3 (67%)
		Ig strand B	251..259	CDD:409401	4/7 (57%)
		Ig strand C	264..270	CDD:409401	4/5 (80%)
		Ig strand C'	272..274	CDD:409401	0/1 (0%)
		Ig strand D	277..281	CDD:409401	3/3 (100%)
		Ig strand E	286..291	CDD:409401	3/4 (75%)
		Ig strand F	298..305	CDD:409401	6/6 (100%)
		Ig strand G	309..318	CDD:409401	3/8 (38%)
		FN3	322..411	CDD:238020	82/91 (90%)
		FN3	<382..747	CDD:442628	301/369 (82%)
		FN3	712..810	CDD:238020	79/97 (81%)
		FN3	832..898	CDD:214495	50/65 (77%)
		FN3	<867..1269	CDD:442628	325/401 (81%)
		fn3	914..998	CDD:394996	69/83 (83%)
		R-PTPc-LAR-1	1498..1735	CDD:350401	205/236 (87%)
		R-PTP-LAR-2	1784..2021	CDD:350402	223/236 (94%)
Lar	XP_061516302.1	None