Protein Alignment Lar and Ptp36E

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: XP_061517629.1
• Gene: Ptp36E / 1277872
• VectorBaseID: AGAMI1_001392
• Length: 682
• Species: Anopheles gambiae
• Alignment Length: 660
• Identity: 192/660 - (29%)
• Similarity: 324/660 - (49%)
• Gaps: 59/660 - (8%)

  Fly  1407 RRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHP--PIPISEFANHIERL 1469
            ::::...:....::...:..:.|.:|....|.|.:...:.:.|...:.|  |..:..||...|:
Mosquito    28 KKKKTLSSTSLVSIPNTIKLSMLNSGLLSLDKVKLSARDEKNPLSQTMPDKPTELRHFAKLCEQ- 91

  Fly  1470 KSNDNQKFSQEYESIEPGQQFTWDNSNLEH-----NKSKNRYANVTAYDHSRVQLPAVEGVVGSD 1529
                .:||...|: :|.......:.::.:|     |..||:......||::||.|...:....||
Mosquito    92 ----RRKFPILYK-LEFQTAVKVETNSCKHALRKANALKNQNPKCIPYDYNRVVLDKYDNTPDSD 151

  Fly  1530 YINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWP--TR 1592
            ||||:|.|...|.|||:.||||.::|.:|||||.|:...:.|||:|:..:.|::.|.||||  ..
Mosquito   152 YINASYVDSLLKPNAYIVTQGPTEDTVLDFWRMVWQENCSCIVMLTKTFDFTKVMCVQYWPPNKE 216

  Fly  1593 GTETYGQIFVTITETQELATYSIRTFQLCRQG----FNDRREIKQLQFTAWPDHGVPDHPAPFLQ 1653
            ..|.||.:.:||...:|||.:.||||:|.:..    .::.|.:.|..:|.|..|..|...| .|:
Mosquito   217 KEEIYGDMHITIQSEEELANFHIRTFRLFKLNKDNVVSEERFLLQFHYTEWHSHTCPFSNA-ILE 280

  Fly  1654 FLRRCRAL------TPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQR 1712
            |.||.||:      .....||::|||:.|.||:|.|:.||:.:|..:.|....::|::..||..|
Mosquito   281 FRRRVRAVVGTIIKANSRIGPMLVHCNDGGGRSGVYLAIDANMELAEEEDSFHVFGYLKKLRQSR 345

  Fly  1713 NYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMD 1777
            ..:::..|||.|::|.:.|.||||.:..|.:.|...|::..:.:|...::..:.|:.::..   .
Mosquito   346 KGLIENVDQYKFVYDTLEEFIICGNSWFPVKELSQRLKEKSLKDPLTKMNSYQREYAQICK---Q 407

  Fly  1778 SSKFVTANLPC-------NKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYI 1835
            :.:|...:  |       |:.|||.|..:|.::.|.||:...|...:||:||.|:|||.....||
Mosquito   408 TPRFTIGD--CAGGHRGDNREKNRDVLCVPPDNFRPYLSSFQGNSFTDYINAVFVDGYTKPREYI 470

  Fly  1836 AAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQY---WPHER-SVRY-QYYVVDPIA 1895
            ..:.|:|....:||.::::|....||:|.:.....:    ||   ||..| |.:| ..:.:|.|:
Mosquito   471 VTEWPLQKTCGEFWSLVYDHECAAVVVLCQPPHNSQ----QYPAFWPEGRHSKKYGPVFTIDHIS 531

  Fly  1896 EYNMPQYKLREFKV-------TDARDG---SSRTVRQFQFIDWP-EQGVPKSGEGFIDFIGQVHK 1949
            ..:....|...|::       |:...|   ..|||:.||...|| ...||.|....::.:..|.:
Mosquito   532 HQHYSNIKSWIFRINKKVISLTELMAGVKAPPRTVQLFQLTCWPMGHKVPTSTNSLVELMNMVER 596

  Fly  1950 TKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYH 2014
            .:::... ||:.|....|..|:||:...:..:|::...|.:||||.|:.:|..||.:|....:|.
Mosquito   597 WRQKTDY-GPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVDNMTEYK 660

  Fly  2015 FCYRAALEYL 2024
            :||...|.|:
Mosquito   661 YCYDLVLHYV 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	93/253 (37%)
		R-PTP-LAR-2	1784..2021	CDD:350402	74/259 (29%)
Ptp36E	XP_061517629.1	None