DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and IA-2

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_061516681.1 Gene:IA-2 / 1277829 VectorBaseID:AGAMI1_004623 Length:1037 Species:Anopheles gambiae


Alignment Length:952 Identity:211/952 - (22%)
Similarity:323/952 - (33%) Gaps:315/952 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1130 RLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVN------VS 1188
            ||||.:....|:              .|.||.. ..:.|.|.|.|.::|.|...|:|      ..
Mosquito   298 RLTPADVDPEFE--------------YIYPKTS-SFREYAKEHHIPKISNFAPENINRLQQEAAG 347

  Fly  1189 AIPS-----DYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLV 1248
            |..:     |..|..|.|        |.....:.:.....|..|.....| ..|..|..:....|
Mosquito   348 AAKANDPNVDKFYTHPHK--------ALAQHARNEIPAAGNLRESAAYAP-GPEAGGMYTEGGFV 403

  Fly  1249 VVPEDKSNLHKIPDQFLTDDLLPGRNKPER--------PNAPYIAAKFPQRSIPFTFHLGSGDDY 1305
            .||:...:..|...:.|.|::| |..:.||        |.||..:::.|  |.|......|.|..
Mosquito   404 YVPKSGGSPGKDEARTLLDNIL-GFTRRERLDVKKPGPPAAPPPSSQSP--SEPPKETAPSQDKA 465

  Fly  1306 HNFTNRKLEREKRYRIFVRA-------VVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPN 1363
            |.....|..:.|: .:|...       .|||...|:...:|..                     |
Mosquito   466 HGEEGEKRPKSKK-ELFAHTDDDHAPHSVDTEYAHVILKNPID---------------------N 508

  Fly  1364 WPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAAD 1428
            |           ||...|:..:..|:..                         |...|.|     
Mosquito   509 W-----------KDGSRIVAALAELLNM-------------------------QGYFTHP----- 532

  Fly  1429 LGAGPTPSDPVDMRRLNFQTPGMISHP----------PIPISEFANHIERL------------KS 1471
                     .||...::|:..   ::|          .|..|.|.|::.|.            |:
Mosquito   533 ---------RVDRHEVSFRVE---ANPDRKTAADVAKQINDSRFKNNLSRRLGVLVIQAGVGDKT 585

  Fly  1472 NDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYC 1536
            .:....||..:.:|       |..|:.|         |.||..:.....||..|..:.::     
Mosquito   586 KETDVSSQRLKRVE-------DGPNVTH---------VMAYMFAGAGAAAVIVVAMTLFL----- 629

  Fly  1537 DGYRKHNAYVATQGPLQ-------ETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGT 1594
              .|||:......|.||       .:..|:..:|                |.|:...:..|. |:
Mosquito   630 --IRKHDKKKDKLGGLQSGLGGGDSSSKDYQDLC----------------RARMAGGKTGPA-GS 675

  Fly  1595 ETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCR 1659
            ::.|.....:|:..|....|.|:                 ..::|.:.                 
Mosquito   676 DSPGGRITALTKEAEARPPSSRS-----------------STSSWSEE----------------- 706

  Fly  1660 ALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIF 1724
                    |.:.:.....|    ::|:..|.:.::::.           |.||.:          
Mosquito   707 --------PALTNMDISTG----HMVLSYMEDHLRNKG-----------RLQREW---------- 738

  Fly  1725 IHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCN 1789
                  ||:.....|..||:.....|...:..||..                             
Mosquito   739 ------EALCRYEAEPSARDAALQAQCAPLNRPGAP----------------------------- 768

  Fly  1790 KHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRS-AYIAAQGPVQDAAEDFWRMLW 1853
                     |||:.|||.|..:...||.||:|||.|..:..|: ||:|||||:|.....||:|:|
Mosquito   769 ---------LPYDHSRVVLNHLANAEGMDYINASTITDHDPRAPAYVAAQGPMQSTLAHFWQMVW 824

  Fly  1854 EHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYN-MPQYKLREFKVTDARDGSS 1917
            |..:.::|.|.:|:|.|...|.:|||.|.:..|..|.|..::|:. ...|.:|.|.:.:.|.|.:
Mosquito   825 EQGAVVLVALCRLQENGESACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTGET 889

  Fly  1918 RTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLE 1982
            |||.||.|:.||:.|||.|.:..:||..:|:|:..  |:..||.||.|.|.||:|.:|.|.:||.
Mosquito   890 RTVTQFHFLSWPQGGVPTSAKALLDFRRKVNKSYR--GRSCPIVVHSSNGSGRTGAYILLDLVLG 952

  Fly  1983 RMQYEGV--LDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE 2022
            ||. :|.  :|:..|:..||.||..:|.|..|:.|...|..|
Mosquito   953 RMN-KGAREIDIAATLEHLRDQRAGLVATRQQFEFVLMAVAE 993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628
FN3 712..810 CDD:238020
FN3 832..898 CDD:214495
FN3 <867..1269 CDD:442628 33/149 (22%)
fn3 914..998 CDD:394996
R-PTPc-LAR-1 1498..1735 CDD:350401 34/243 (14%)
R-PTP-LAR-2 1784..2021 CDD:350402 92/240 (38%)
IA-2XP_061516681.1 None
Blue background indicates that the domain is not in the aligned region.

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