Protein Alignment Lar and Ptp10D

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: XP_061506139.1
• Gene: Ptp10D / 1274091
• VectorBaseID: AGAMI1_005906
• Length: 1864
• Species: Anopheles gambiae
• Alignment Length: 1859
• Identity: 407/1859 - (21%)
• Similarity: 695/1859 - (37%)
• Gaps: 471/1859 - (25%)

  Fly   138 GFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKDGFLQIENSREE 202
            |..::.:.||.:.::.....|.....||||.||
Mosquito    72 GADLVIEIPGNQGLDDSFYRLDYYPPIGNPAPN-------------------------------- 104

  Fly   203 DQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHVK 267
                 ..:|...:|.|..                      .|..:.|:..|.......|  .|..
Mosquito   105 -----ATIASRDVGDEIQ----------------------FSNGLPGTRYNFWLYYTNS--THKD 140

  Fly   268 WMKGSEDLTPENEMPI--------GRNVLQLINIQESA--NYTCIAASTLGQIDSVSVVKVQSLP 322
            |:..:..:|...:.|.        |:||  :||....|  ||:......||..|:.:..:..::.
Mosquito   141 WLTWTVSITTAPDPPANLTVIPRSGKNV--IINWSPPAQGNYSSFKLKILGLSDNFATNQTVAIE 203

  Fly   323 TAPTDVQISEVT--AT-SVRLEWSYKGPEDLQYYVIQYKPKNANQA------------------- 365
            .......:.::|  || .|:....|.|.|.:.|....:..|.....
Mosquito   204 DNQFQYMVRDLTPGATYQVQAYTLYDGKESVAYTSRNFTTKRYRHKDLLDIKILREPNTPGKFIV 268

  Fly   366 -FSEISGIITMYYVVRALSPYTEYEFYVIAVNNIG-------RGPPSAPATCTTGDFSFGG---- 418
             |...:.::.::........||.|:..:...:.:|       .|.|..||..     :|.|
Mosquito   269 WFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDALGSVLYVQKEGEPPGPAQA-----AFKGLVPG 328

  Fly   419 --------TKME---SAPRNVQVRTLSSSTMVIT--------------WEPPETPNGQVTGYKVY 458
                    |..|   |.|...|.||:....|.:|              ||.|: ...:...|:|.
Mosquito   329 RAYNISVQTMSEDEISLPTTAQYRTVPLRPMNVTFDKKSITENSFKVMWEAPK-GTSEFDKYQVS 392

  Fly   459 YTTNSNQPEASWNSQMVDNSELTTV---SELTPHAIYTVRVQAYT-SMGAGPMS-----TPVQVK 514
            .:|:..|.....|    ||..:..:   ..|.|...|.|.|:..: .:.:.|.|     .|:.||
Mosquito   393 LSTSRRQQAVLRN----DNENMAWLEFKDNLDPGKTYQVVVKTVSGKVTSWPASGDVTLKPLPVK 453

  Fly   515 AQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRIS-NSEAYTL 578
            ..|..         ||.....:|:.|.....|:::  .|.:.:::...|......:| |..::.|
Mosquito   454 QLQSY---------TDSKTGVITISWKPDELSTQD--EYRISYHELETNNGDSSTMSTNQTSFAL 507

  Fly   579 DGLYPDTLYYIWLAARSQRGEG-------ATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLP 636
            :.|.|...|.:.:.|.|::.|.       .|.|..|:           |..:.:....:::||
Mosquito   508 ESLLPGRNYSVTVQALSRKMESNETVIFVVTRPSSPI-----------IEDLKSIREGLNISW-- 559

  Fly   637 PPVERS--NGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPR 699
                :|  |.:...|:|.:..  .:.::..|:....:.:|...|.....|::.|.|   |..|.|
Mosquito   560 ----KSDVNSKQDKYEVTYTR--NDTNDGKTVLTTESRLVFTNLYPGAGYEVKVFA---VSHGLR 615

  Fly   700 SHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNE 764
            |.|... .|...|..|:::....:.|.|:.|.||||...:       :..::...|.|.:   .:
Mosquito   616 SEPHSY-FQAVYPNPPRNMTIEKVTSNSVLVHWKPPERSE-------FTEYSIRYRTESE---KQ 669

  Fly   765 PFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLK-IMERE 828
            ..:...|...|.:||.:.|..||:|||          .:.:..|::|....|..||... :....
Mosquito   670 WIRLPSVKATEADVTDMTPGEKYTIQV----------NTVSYGVESPNPQQVNQTVRPNPVSNIA 724

  Fly   829 PIV---SIELEWERPAQTYGELRGYRLRWGVKDQ----ALK------------------EEMLSG 868
            |:|   :|.||:.||.   |.:..|.:.|...:|    ::|                  |:.:..
Mosquito   725 PLVDSNNITLEFPRPE---GRVETYIIHWWPTEQPEQVSMKNFTEVNTILPYPGTLSDDEKTVEE 786

  Fly   869 PQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITI--RFQTPDVLCV 931
            |.:.:....:|..||.|.|::...:: |:..:..|: ||  .|.....|.:.|  ...|.|::.:
Mosquito   787 PPLVRLLIGDLMSGVMYNFKIQTISY-GLTSDLTKL-QT--RTMPLIQSEVVIVNNMHTRDMVTL 847

  Fly   932 TWDPPTREHRNGIITRYDVQFHKKIDHGLGSER---NMTLRKAVFTNLEENTEYIFRVRAYTKQG 993
            ::.|..::.     :::|:......|..:..:.   |.|.||..||.|....  ::.:..:|.
Mosquito   848 SYTPTPQQS-----SKFDLYRFSLGDPSIPDKEKLANDTDRKVTFTGLTPGR--LYNITVWTV-- 903

  Fly   994 AGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMT--------- 1049
            :|..|.:.|...:|........|:|.:.::....:.|:  ..:|:...:::.|.|.
Mosquito   904 SGKVSSQPIQRQDRMFPDPITMLEATSINDTWIALKWD--IPKGEYTSFEVQYLMNDSHYVQNYT 966

  Fly  1050 -----AVEDLDDWQTKTVGL-----TESADLVNLEKFAQYAVAIAARF--KNGL-GRLSEKVTVR 1101
                 .:.||...:..|:.:     |||:.|       :.::.|:|.|  |..| ||:.:...:.
Mosquito   967 VNNHITITDLKPHRNYTITVVVRSGTESSVL-------RVSLPISANFQTKEALPGRMDKFAPID 1024

  Fly  1102 IKPEDVPLNLRAHDVSTHSMTLSWS-PP------IRLTPVNYKISFDAMKVFVDSQGFSQTQIVP 1159
            |:|.::              |..|| ||      ||...:.|.:           .|...||:..
Mosquito  1025 IQPSEI--------------TFEWSLPPNEQNGIIRQFTITYGL-----------DGSQHTQVKD 1064

  Fly  1160 KREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRP----PTKITVTTQMAAPQP---MVKP 1217
            .|...|:..:|.     |.|..:|...:.| .:...|.|    ..|:.:   :|.|:|   :|..
Mosquito  1065 FRPNELRGSIKA-----LQPGKSYVFRIQA-KTAIGYGPEHIWKQKMPI---LAPPKPETQVVPT 1120

  Fly  1218 DFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTD----DLLPGRNKPER 1278
            :........||.......|::.|.::.|.:::..:|..|...:......|    .:.|    |.:
Mosquito  1121 EVGSSATTIEIRFRKHYFSDQNGVVTTYTIIIAEDDSKNASGLEMPSWRDVQSYSVWP----PYQ 1181

  Fly  1279 PNAPYIAAKFPQRSIPFTFHLGSGDDY-----------HNFTNRKLEREKRYRIFVRAVVDTPQK 1332
            ...||           :.|...|.:|:           ..:.|..|:....|::.|||.. .|.|
Mosquito  1182 VIEPY-----------YPFKNSSVEDFTIGTENCDAKKTGYCNGPLKSGTTYKVKVRAFT-APDK 1234

  Fly  1333 HLYTSSPFS-----EFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVST 1392
              :|.:.:|     ..||:|                  |:...|:        |:.:.:||::..
Mosquito  1235 --FTDTAYSYPIRTALLSVD------------------AQDNTSL--------IVSITVPLLIIA 1271

  Fly  1393 FIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPI 1457
            .:|.   :||.:.:||....||.:|.  |...|:       .|...::..|            |:
Mosquito  1272 MLVG---VVLFLRRRRHTGRKTTEQR--TNDNMS-------LPDSTIETSR------------PV 1312

  Fly  1458 PISEFANHIERLKSNDNQKFSQEYESIEP-GQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPA 1521
            .:..||.|...:.::.:.:||:|:|.::. |:......::|..|:.|||:.|:..|||||.:|..
Mosquito  1313 LVKNFAEHYRMMSADSDFRFSEEFEELKHIGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQP 1377

  Fly  1522 VEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCD 1586
            |:...|||||||||..|:.....::.|||||..|..||||||||..:..|||:||..|:.|.|||
Mosquito  1378 VDDEEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRTFEKGREKCD 1442

  Fly  1587 QYWPTRGTET-YGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAP 1650
            .|||...... ||.|.||:........:.|..|.:.|.  ..:|.|:...||.|||.|||:.|..
Mosquito  1443 HYWPHDTVPVYYGDIKVTLLNDSHYPDWVITEFMMTRG--EQQRIIRHFHFTTWPDFGVPNPPQT 1505

  Fly  1651 FLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYM 1715
            ..:|:|..|....|:..|::|||||||||:|.:|.:|.:|::::....:||:|.|..:|.:|.:|
Mosquito  1506 LARFVRAFRERVGPDQRPIVVHCSAGVGRSGTFITLDRILQQIQVSDYVDIFGIVWAMRKERVWM 1570

  Fly  1716 VQTEDQYIFIHDAILEAIICGVTEVPARNLHTHL-------------QKLLITEPGE-------- 1759
            ||||.|||.||..:|  ::....|...|.:|.:.             ::|||....:
Mosquito  1571 VQTEQQYICIHQCLL--VVLEGKEGTEREIHDNQGYEEPRDDDQQSEEQLLIENRSDDELDEVAA 1633

  Fly  1760 --------TISGMEVEFKKLSNVKMDSSKFVTANLPCNK 1790
                    |..|:|       |.::|..:..|..:..|:
Mosquito  1634 REQHQQNGTAGGIE-------NHELDRRRSATVEIVDNE 1665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250	12/86 (14%)
		Ig strand B	157..161	CDD:409353	1/3 (33%)
		Ig strand C	170..174	CDD:409353	1/3 (33%)
		Ig strand E	192..196	CDD:409353	0/3 (0%)
		Ig strand F	206..211	CDD:409353	0/4 (0%)
		Ig strand G	218..221	CDD:409353	1/2 (50%)
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401	19/91 (21%)
		Ig strand A	237..239	CDD:409401	0/1 (0%)
		Ig strand A'	244..248	CDD:409401	1/3 (33%)
		Ig strand B	251..259	CDD:409401	1/7 (14%)
		Ig strand C	264..270	CDD:409401	2/5 (40%)
		Ig strand C'	272..274	CDD:409401	0/1 (0%)
		Ig strand D	277..281	CDD:409401	0/3 (0%)
		Ig strand E	286..291	CDD:409401	2/4 (50%)
		Ig strand F	298..305	CDD:409401	2/6 (33%)
		Ig strand G	309..318	CDD:409401	1/8 (13%)
		FN3	322..411	CDD:238020	18/118 (15%)
		FN3	<382..747	CDD:442628	87/419 (21%)
		FN3	712..810	CDD:238020	22/97 (23%)
		FN3	832..898	CDD:214495	18/87 (21%)
		FN3	<867..1269	CDD:442628	85/446 (19%)
		fn3	914..998	CDD:394996	16/88 (18%)
		R-PTPc-LAR-1	1498..1735	CDD:350401	103/237 (43%)
		R-PTP-LAR-2	1784..2021	CDD:350402	1/7 (14%)
Ptp10D	XP_061506139.1	None