Protein Alignment Lar and Ptpn6

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_446360.2
• Gene: Ptpn6 / 116689
• RGDID: 620660
• Length: 597
• Species: Rattus norvegicus
• Alignment Length: 356
• Identity: 137/356 - (38%)
• Similarity: 188/356 - (52%)
• Gaps: 40/356 - (11%)

  Fly  1467 ERLKSNDNQK--FSQEYESIEPGQQFTWDNSNLE----HNKSKNRYANVTAYDHSRVQLPAVE-G 1524
            ::.:|.|..|  |.:|:||::. |:....:..||    .|||||||.|:..:|||||.|...: .
  Rat   234 KKQESEDTAKAGFWEEFESLQK-QEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSN 297

  Fly  1525 VVGSDYINANYCDGY-----RKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIK 1584
            :.|||||||||....     .....|:|:||.|..|..|||:|.|:..|..|||.||..|:.|.|
  Rat   298 IPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNK 362

  Fly  1585 CDQYWPTRGTE-TYGQIFVTITETQELATYSIRTFQLCRQGFNDR-REIKQLQFTAWPDHGVPDH 1647
            |..|||..||: .||...||..:..:.|.|.:||.|:......|. |||...|:.:|||||||..
  Rat   363 CVPYWPEVGTQRVYGLYSVTNCKEHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSE 427

  Fly  1648 PAPFLQFLRRC--RALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKI---IDIYGHVTC 1707
            |...|.||.:.  |..:.|.:||:|||||||:||||..||||.::|.:..:.:   |||...:..
  Rat   428 PGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESVSTKGLDCDIDIQKTIQM 492

  Fly  1708 LRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLS 1772
            :||||:.|||||.||.||:.||            |:.:.|..:||.|.   ::..|.|.|:..::
  Rat   493 VRAQRSGMVQTEAQYKFIYVAI------------AQFIETTKKKLEII---QSQRGQESEYGNIT 542

  Fly  1773 NVKMDSSKFVTANLPCNKHKNRLVHILPYES 1803
            ......|....|:...:|||..:     ||:
  Rat   543 YPPALRSAHAKASRTSSKHKEEV-----YEN 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	113/253 (45%)
		R-PTP-LAR-2	1784..2021	CDD:350402	6/20 (30%)
Ptpn6	NP_446360.2	SH2_N-SH2_SHP_like	6..103	CDD:198203
		SH2_C-SH2_SHP_like	111..217	CDD:198185
		PTPc-N6	255..520	CDD:350454	116/277 (42%)