DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptpru

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_017448609.1 Gene:Ptpru / 116680 RGDID:620782 Length:1452 Species:Rattus norvegicus


Alignment Length:1753 Identity:436/1753 - (24%)
Similarity:663/1753 - (37%) Gaps:519/1753 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   442 WE----------PPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIY---- 492
            ||          |.:.|:|      .|...|::|......:.::    ..|:||...|.:.    
  Rat    51 WEQVRIHPGTRTPADLPHG------AYLMVNASQHAPGQRAHII----FQTLSENDTHCVQFSYF 105

  Fly   493 ----------TVRVQAYTSMGAGPMSTPV-QVKAQQGVPSQPSNFRATDIGETAVTLQW------ 540
                      |:.|  |..:..||:.:.| .:....|        |.....|.||:..|      
  Rat   106 LFSRDGHSPGTLGV--YVRVNGGPLGSAVWNMTGSHG--------RQWHQAELAVSTFWPNEYQV 160

  Fly   541 -----TKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARS----- 595
                 ..|.|.....:...|.::...|...|..|:.:.|.    ....:..:....|.|:     
  Rat   161 LFEALISPDHKGYIGLDDILLFSHPCAKAPHFSRLGDVEV----NAGQNASFQCMAAGRAAEAER 221

  Fly   596 ---QRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVG 657
               ||..|...|...||...:    |...|      |..|:                     .||
  Rat   222 FFLQRQSGVLVPAAGVRHISH----RRFLA------TFPLA---------------------SVG 255

  Fly   658 REDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRS------HPIILRTQEDVPGDPQ 716
            |.:.:.                    |:       .|...||.      ..:|::........||
  Rat   256 RSEQDL--------------------YR-------CVSQAPRGAGVSNFAELIVKEPPTPIAPPQ 293

  Fly   717 DVKATP------LNSTSIHVSWKPPLEKD-RNGIIRG--YHIHAQELRDEGKGFLNEPFKFDVVD 772
            .::|.|      ||:.|| :...|.:.|: ...:.||  ..:||..|:                 
  Rat   294 LLRAGPTYLIIQLNTNSI-IGDGPIVRKEIEYRMARGPWAEVHAVNLQ----------------- 340

  Fly   773 TLEFNVTGLQPDTKYSIQVAALTRKGDGDR---SAAIVVKTPGGVPVRPTVSL---KIMEREPIV 831
              .:.:..|.|||:|.|.| .|||.|||..   ...::.:|....|.|....|   :|..|:   
  Rat   341 --TYKLWHLDPDTEYEISV-LLTRPGDGGTGRPGPPLLSRTKCAEPTRAPKGLAFAEIQARQ--- 399

  Fly   832 SIELEWE------RPAQTYGELRGYRLR-WGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRV 889
             :.|:||      ....||.....|... .|..:|.::|.:......::....||........|:
  Rat   400 -LTLQWEPLGYNVTRCHTYAVSLCYHYTLGGSHNQTIRECVKMERGASRYTIKNLLPFRNVHVRL 463

  Fly   890 AGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTP--DVLCVTWDPPTREHRNGIITRYDVQF 952
            ..:|..|..:.....|||.|..|||..:. ::.| ||  |::.:.|:.|  :..||:||:|::.:
  Rat   464 ILTNPEGRKEGKEVTFQTDEDVPGGIAAE-SLTF-TPLEDMIFLKWEEP--QEPNGLITQYEISY 524

  Fly   953 HKKIDHG------------LGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVET 1005
             :.|:..            :...||.|..  ||:||:..|.|:|.|||.|               
  Rat   525 -QSIESSDPAVNVPGPRRTISKLRNETYH--VFSNLQPGTTYLFSVRART--------------- 571

  Fly  1006 ERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADL 1070
                                                                             
  Rat   572 ----------------------------------------------------------------- 571

  Fly  1071 VNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVN 1135
                                                                             
  Rat   572 ----------------------------------------------------------------- 571

  Fly  1136 YKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPT 1200
                         |:||.|..:                       |....|:||...||:     
  Rat   572 -------------SKGFGQAAL-----------------------TEITTNISAPSFDYA----- 595

  Fly  1201 KITVTTQMAAPQPMVKPDFYGVVNGEE---ILVILPQASEEYGPISHYYLVVVPEDKSNLHKIP- 1261
                    ..|.|:          ||.   |.|:|..|.....|||.|.:||..|....|.:.| 
  Rat   596 --------DMPSPL----------GESENTITVLLRPAQGRGAPISVYQVVVEEERPRRLRREPG 642

  Fly  1262 --DQF---LTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRI 1321
              |.|   ||.:....|.......|. :||.....::|||  :|....|..|.|..||..|.|.|
  Rat   643 GQDCFSVPLTFETALARGLVHYFGAE-LAASSLLEAMPFT--VGDNQTYRGFWNPPLEPRKAYLI 704

  Fly  1322 FVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVL 1386
            :.:|.     .||...:..:.............:||            :.|::..:|..::..:.
  Rat   705 YFQAA-----SHLKGETRLNCIRIARKAACKESKRP------------LEVSQRSEEMGLILGIC 752

  Fly  1387 PLMVSTFIVSTALIVLCVVKRR---------------------RQPCKTPDQAAVTRPLM----- 1425
            ...::..|:....|::.:.|.|                     ||. ||....||.|...     
  Rat   753 AGGLAVLILLLGAIIIIIRKGRDRYAYSYYPKPVNMAKATVNYRQE-KTHMMTAVDRSFTDQSTL 816

  Fly  1426 -----------------------------AADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISE 1461
                                         |:.| .|.:|..|...:...:.| |.: ||.:.:::
  Rat   817 QEDERLGLSFMDAPGYSPRGDQRSSGVTEASSL-LGGSPRRPCGRKGSPYHT-GQL-HPAVRVAD 878

  Fly  1462 FANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVV 1526
            ...||.::|:.:...|.|||||...|    ||.:..:......|...|:|||..||:|..:.|..
  Rat   879 LLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKLKSGRQEPVSAYDRHRVKLHPMLGDP 939

  Fly  1527 GSDYINANYCD------GYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKC 1585
            .:|||:|||.|      ||.:.|.::|||||..|...|||||.|:.:..::||:::|.|..|:||
  Rat   940 DADYISANYIDIRINRQGYHRSNHFIATQGPKPEMIYDFWRMVWQEQCVSVVMISKLVEVGRVKC 1004

  Fly  1586 DQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAP 1650
            .:||| ..::.||.|.:|:.:|:.||.|.:|||.|.|:|::.|.|::|..|||||:||||.|...
  Rat  1005 SRYWP-EDSDMYGDIKITLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATG 1068

  Fly  1651 FLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYM 1715
            .|.|:||.:|.|||::|||::|||||.||||||||:|.||:..:.|.::|||..|..|.::|..|
  Rat  1069 LLAFIRRVKASTPPDAGPVVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNM 1133

  Fly  1716 VQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNV--KMDS 1778
            :|||:||||||||||||.:||.|.:|........::::..:|....|.:..||:.|::|  .:|.
  Rat  1134 IQTEEQYIFIHDAILEACLCGETTIPVNEFKATYREMIRIDPQSNSSQLREEFQTLNSVTPPLDV 1198

  Fly  1779 SKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQD 1843
            .:...|.||.|:.|||.:.:||.:....:|....| :.::|:||:..|.|...:|:|....|:|.
  Rat  1199 EECSIALLPRNRDKNRSMDVLPPDRCLPFLISSDG-DPNNYINAALTDSYTRSAAFIVTLHPLQS 1262

  Fly  1844 AAEDFWRMLWEHNSTIVVMLTKLKEMGRE-KCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREF 1907
            ...||||:::::..|.:|||.:|.:.... .|.||||.....:|....|:.::.........|.|
  Rat  1263 TTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFVSGTANEDLVSRVF 1327

  Fly  1908 KVTDARDGSSR------TVRQFQFIDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCS 1965
            :|    ..|||      .||.|||:.|.. :..|.|.:.|:..:.:|.|.:.:.| ||...|||.
  Rat  1328 RV----QNSSRLQEGHLLVRHFQFLRWSAYRDTPDSRKAFLHLLAEVDKWQAESG-DGRTVVHCL 1387

  Fly  1966 AGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFD 2028
            .|.||||.|...:.|||.::...::|||...:.||:.:|.||:|.|||||||..|||||.:.:
  Rat  1388 NGGGRSGTFCACATVLEMIRCHSLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEALE 1450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628 63/363 (17%)
FN3 712..810 CDD:238020 28/109 (26%)
FN3 832..898 CDD:214495 14/72 (19%)
FN3 <867..1269 CDD:442628 69/424 (16%)
fn3 914..998 CDD:394996 27/97 (28%)
R-PTPc-LAR-1 1498..1735 CDD:350401 118/242 (49%)
R-PTP-LAR-2 1784..2021 CDD:350402 84/244 (34%)
PtpruXP_017448609.1 MAM 22..186 CDD:214533 27/154 (18%)
fn3 291..365 CDD:394996 26/94 (28%)
FN3 <347..>624 CDD:442628 86/492 (17%)
fn3 494..577 CDD:394996 29/246 (12%)
PTP_DSP_cys 943..1153 CDD:475123 108/210 (51%)
R-PTPc-U-2 1238..1444 CDD:350485 74/210 (35%)
Blue background indicates that the domain is not in the aligned region.

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