Protein Alignment Lar and Ptprn

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: XP_063122605.1
• Gene: Ptprn / 116660
• RGDID: 620777
• Length: 1065
• Species: Rattus norvegicus
• Alignment Length: 634
• Identity: 155/634 - (24%)
• Similarity: 240/634 - (37%)
• Gaps: 182/634 - (28%)

  Fly  1145 VFVDSQGFSQTQIVPKREIILKHYVKTH----TINELSPFTTYNV-----NVSAIPSDYSYRPPT 1200
            :..|.:..|....|...||:.:|...|.    .|:.:.|..|:.:     |:|
  Rat   560 IVTDQKPLSLVAGVKLLEILAEHVHMTSGSFINISVVGPAVTFRIRHNEQNLS------------ 612

  Fly  1201 KITVTTQMAAPQPMVKPDF----------YGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKS 1255
             :...||.|.   :||.:.          .||...||...:||:.:....|:....|.:|
  Rat   613 -LADVTQQAG---LVKSELEAQTGLQILQTGVGQREESAAVLPRQAHGISPMRSLLLTLV----- 668

  Fly  1256 NLHKIPDQFLTDDLLPG--------------RNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYH 1306
                         .|.|              |:..::.:...:||..|:.:     |..:..:|.
  Rat   669 -------------ALAGVAGLLVALAVALCMRHHSKQRDKERLAALGPEGA-----HGDTTFEYQ 715

  Fly  1307 NFTNRKLEREKRYRIFVRAV-VDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEV 1370
            :...:.:..:.   :|.||. ...|.:....||.||     |..:|.|..  |...|:|..||
  Rat   716 DLCRQHMATKS---LFNRAEGQPEPSRVSSVSSQFS-----DAAQASPSS--HSSTPSWCEEP-- 768

  Fly  1371 SVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTP 1435
             ...|.|                 :||..::|..::
  Rat   769 -AQANMD-----------------ISTGHMILAYME----------------------------- 786

  Fly  1436 SDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESI-----EPGQQFTWDNS 1495
                                           :.|::.|  :.::|::::     ||.   |...:
  Rat   787 -------------------------------DHLRNRD--RLAKEWQALCAYQAEPN---TCATA 815

  Fly  1496 NLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHN----AYVATQGPLQETF 1556
            ..|.|..|||:.:...|||:|::|........||||||:   ...:|:    ||:||||||..|.
  Rat   816 QGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINAS---PIIEHDPRMPAYIATQGPLSHTI 877

  Fly  1557 VDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVT-ITETQELATYSIRTFQL 1620
            .|||:|.||.....|||:|.|.|....:||:|||..|:..|....|. ::|......:.:|:|.|
  Rat   878 ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGSSLYHVYEVNLVSEHIWCEDFLVRSFYL 942

  Fly  1621 CRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIV 1685
            ......:.|.:.|..|.:||..|.|....|.|.|.|:........|.|:|||||.|.||||.||:
  Rat   943 KNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYIL 1007

  Fly  1686 IDSMLERM-KHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI 1733
            ||.:|.|| |..|.|||...:..:|.||..:|:::||:.|...|:.|.:
  Rat  1008 IDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628	26/142 (18%)
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	94/242 (39%)
		R-PTP-LAR-2	1784..2021	CDD:350402
Ptprn	XP_063122605.1	None