DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and ptprf

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_031756782.1	Gene:	ptprf / 100493254	XenbaseID:	XB-GENE-495325	Length:	1920	Species:	Xenopus tropicalis

Alignment Length:	2095	Identity:	981/2095 - (46%)
Similarity:	1288/2095 - (61%)	Gaps:	253/2095 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PIAALSLLVLS-LLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNG 73
            |.:.||||:|| ::.....|:..|.:.|..:|||.:|....||||||.|.|..||.|.|.|.|.|
Frog     3 PCSCLSLLILSAIVLCCSITLTQADNEPVFVRKPDDQIGISGGVASFVCQATADPKPRITWMKKG 67

  Fly    74 KKVSGTQSRYTVLE-QPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPA 137
            ||||  ..|:.|:| ..|..|:|||:|:|..||:|.|||.|.|.||: :::.|.||:.|.::.|.
Frog    68 KKVS--SQRFEVIEFDDGSGSVLRIQPLRVHRDEAIYECTATNSVGE-INSSAKLTVLEEEQLPH 129

  Fly   138 GFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKD---------GF 193
            |||||..||..:|:|...|..|.|.|.|||.|.|.|.|:...||.::....:|.         |.
Frog   130 GFPVIDMGPQLKVVEKTRTATMLCAASGNPDPEITWFKDFLPVDTASSNGRIKQLRSGGTPIRGA 194

  Fly   194 LQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIA 258
            ||||||.|.|||||||||.||.||.:|...||||:||||.|.||.||.. .|||.|.::||:|:|
Frog   195 LQIENSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSN-HEVMPGGSVNLTCVA 258

  Fly   259 VGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPT 323
            ||:|||:||||.|.|:||.|:|||:|||||:|.||:|||||||:|.|:||.|::|:.:.|::||.
Frog   259 VGAPMPYVKWMAGLEELTKEDEMPVGRNVLELTNIKESANYTCVAISSLGMIEAVAQITVKALPK 323

  Fly   324 APTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEY 388
            .|.|..::|.|||||.|.|....|:.:.|||||||||.:..:|.|:.|:.|..|.:..|||::||
Frog   324 PPLDGTVTETTATSVTLTWDSGNPDPVSYYVIQYKPKASESSFQEVDGVATTRYSIGGLSPFSEY 388

  Fly   389 EFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVT 453
            ||.:||||||||||||......||:     ....|.|..||.|.||:|||::.|:.||.||||:.
Frog   389 EFRIIAVNNIGRGPPSEVIEAQTGE-----QAPSSPPLKVQARMLSASTMLVQWDLPEEPNGQIR 448

  Fly   454 GYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQG 518
            |::|||||:.:.|.:.|....|.::.|||:..||....|::||.|:||:|.||.|..:|||.|||
Frog   449 GFRVYYTTDPHLPFSMWQKHNVVDNHLTTIGGLTTGTTYSIRVLAFTSVGDGPPSDIIQVKTQQG 513

  Fly   519 VPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYE-LYWNDTYANQAHHKRISNSEAYTLDGLY 582
            ||:||.:|:|....:|.:.|.|..|  ..|.|..|| |||..|...| .......:.:|.::||.
Frog   514 VPAQPVDFQAEAETDTRILLTWLLP--PQERITKYELLYWEGTDGEQ-QKLMFHPTSSYAVEGLK 575

  Fly   583 PDTLYYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTISLSWLPPPVERSNGR 645
            |||||:..|||.|..|.|..||.|..||.|.  .|||:::...:.|||.|.:||:.||....||.
Frog   576 PDTLYHFRLAAWSDTGVGVYTPAIQARTAQSTPSAPPQDVECSSLSSTAIRVSWVAPPASSRNGA 640

  Fly   646 IIYYKVFFVEVGREDDE---ATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRT 707
            :..|.:.:..:..||..   ..:::.:::|..:.:|::|||||:||.|.|.||.||.|.|||:||
Frog   641 LTRYSLAYQALAGEDTSRHVVDSISPDISSWEIKDLEKWTEYKVWVRAHTDVGAGPESSPIIVRT 705

  Fly   708 QEDVP-GDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVV 771
            .|||| ..|:.|:...:||||:.|:||.||...:||.||||.:  ..:|.||......|...||:
Frog   706 DEDVPSAPPRKVEVDSVNSTSVRVTWKSPLPTKQNGQIRGYQV--TYVRLEGGEPRGNPIIKDVM 768

  Fly   772 ---------DTLEFN--VTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIM 825
                     |..:::  :|||.|:|.|||.|||.|.||||.||...||.|.|.||.:||:   ::
Frog   769 LSEAQWRPEDVGDYDAVITGLSPETTYSITVAAYTTKGDGARSKPKVVSTTGAVPGKPTM---MI 830

  Fly   826 EREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDN----LERGVEYE 886
            ....:.:..::|..|.:..|||.||||::    :.:.|:.......:|....:    |.:|..|.
Frog   831 STTALNTALIQWHPPREIVGELLGYRLQY----KRVDEDRFITIDFSKNEHHHTVTGLHKGASYI 891

  Fly   887 FRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQ 951
            |:::..|..|.|:|..|...|.|..|.|.|.|:.:...|.....|:|:||....|||.||.|.|.
Frog   892 FKLSAKNRAGAGEEYEKEISTAEDFPSGFPQNLQVVGLTTSTTEVSWEPPVLSERNGKITNYTVV 956

  Fly   952 FHKKIDHGLGSERNMT--LRKAVFT--NLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRA 1012
            :     ..:.|::::|  .|....|  ||:.:|.|..:|||.|.:||||.|..:
Frog   957 Y-----RDINSQQDLTNVTRDTHITLVNLKPDTTYDIKVRARTNKGAGPLSPSI----------- 1005

  Fly  1013 PMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFA 1077
                                                         |::|:.:.        :.||
Frog  1006 ---------------------------------------------QSRTMPVD--------QVFA 1017

  Fly  1078 QYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWS-PPIRLTPVNYKISFD 1141
            :                               |.|.:.|:..|:.|||. |....:.|.:||.::
Frog  1018 K-------------------------------NFRVNAVTKTSVLLSWELPDSYKSAVPFKIFYN 1051

  Fly  1142 AMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYN---VNVSAIPSDYSYRPPTKIT 1203
            ...|.||  |.|..::                |:.|.|.|.|:   :|..:......:|    ::
Frog  1052 NQHVEVD--GHSMRKL----------------ISNLKPDTEYSFVLMNRGSSAGGLQHR----VS 1094

  Fly  1204 VTTQMAAPQPMVKPDFYGVVNGEE--ILVILPQASEEYGPISHYYLVVVPEDKS-----NLHKIP 1261
            :.|   ||..:....|......||  ..::|||. :...|:..||:||||.|.|     :..:.|
Frog  1095 IRT---APDVLKSKPFAANKYMEEGRFTLLLPQV-QTTSPVRWYYIVVVPLDSSSGGLNSRWQSP 1155

  Fly  1262 DQFLTDDLLPGRNKPER-------PNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRY 1319
            ::...:.:|...|:..|       .|.|||||:.  .::|.:|.||...:|:.|.|:.|.:..||
Frog  1156 EEMELEQILEAINQGSRRHRRQASKNKPYIAARV--NTLPESFILGDNKEYNGFINKPLNQNLRY 1218

  Fly  1320 RIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWV 1384
            ..||.|.::......|.:||:|:.:.:::                     :|..:.::|||:|||
Frog  1219 TCFVLAALEDGDTKKYAASPYSDDIVVEV---------------------ISQAKQQEEPEMLWV 1262

  Fly  1385 VLPLMVSTFIVSTALIVLCVV--------KRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDM 1441
            :.|::....|:   :||:.::        ||...|....:|:...:..:.|.      .||||:|
Frog  1263 MGPVLAVILII---IIVIAILLFKSKQERKRTNSPSGKDEQSVGLKDCLLAH------SSDPVEM 1318

  Fly  1442 RRLNFQTPG-----------MISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNS 1495
            ||||:||||           |..|||||||:.|::|||||:||..|||||||||:|||||||:||
Frog  1319 RRLNYQTPGSSVPSYPNISSMRDHPPIPISDLADNIERLKANDGLKFSQEYESIDPGQQFTWENS 1383

  Fly  1496 NLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFW 1560
            |||.||.|||||||.|||||||.|.:|:||.|||||||||.|||||.|||:||||||.||..|||
Frog  1384 NLEVNKPKNRYANVIAYDHSRVILTSVDGVPGSDYINANYIDGYRKQNAYIATQGPLPETITDFW 1448

  Fly  1561 RMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGF 1625
            ||.||.:||||||||||||::|:|||||||.||:||||.|.||:.:|.|||||::|||.|.:.|.
Frog  1449 RMVWEQRTATIVMMTRLEEKSRVKCDQYWPGRGSETYGMIQVTLMDTVELATYTVRTFTLYKNGS 1513

  Fly  1626 NDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSML 1690
            :::|:::|.||.||||||||::|.|.|.||||.:...||::||::||||||||||||:||||:||
Frog  1514 SEKRDVRQFQFMAWPDHGVPEYPTPILGFLRRVKGCNPPDAGPMVVHCSAGVGRTGCFIVIDAML 1578

  Fly  1691 ERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLIT 1755
            ||:|.||.:||||||||:|:||||||||||||||||:|:|||::||:||||||:|:.|:|||...
Frog  1579 ERVKLEKTVDIYGHVTCMRSQRNYMVQTEDQYIFIHEALLEAVMCGITEVPARSLYAHIQKLSQV 1643

  Fly  1756 EPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYV 1820
            .|||:::.||:|||.|:|.|..:|:|::|||||||.|||||:|:|||.|||.|.||.|:|||||:
Frog  1644 PPGESVTSMELEFKLLANSKAHTSRFISANLPCNKFKNRLVNIMPYELSRVSLQPIRGVEGSDYI 1708

  Fly  1821 NASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVR 1885
            |||||||||.:..|||.|||:.:..|||||||||||||||||||||:|||||||.||||.|||.|
Frog  1709 NASFIDGYRQQKGYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR 1773

  Fly  1886 YQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKT 1950
            |||:||||:||||||||.||||||||||||.|||:|||||.|||||||||:||||||||||||||
Frog  1774 YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKT 1838

  Fly  1951 KEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHF 2015
            ||||||||||||||||||||:|||||||||||||:||||:|:||||:.||:||||||||||||..
Frog  1839 KEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQL 1903

  Fly  2016 CYRAALEYLGSFDNY 2030
            |||||||||||||:|
Frog  1904 CYRAALEYLGSFDHY 1918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	46/94 (49%)
		I-set	36..129	CDD:254352	46/93 (49%)
		IG_like	146..227	CDD:214653	41/89 (46%)
		Ig	159..228	CDD:299845	38/77 (49%)
		I-set	234..318	CDD:254352	51/83 (61%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	43/67 (64%)
		fn3	324..404	CDD:278470	42/79 (53%)
		FN3	423..514	CDD:238020	42/90 (47%)
		FN3	520..610	CDD:238020	35/90 (39%)
		FN3	616..707	CDD:238020	34/93 (37%)
		FN3	712..810	CDD:238020	45/109 (41%)
		FN3	832..907	CDD:238020	20/78 (26%)
		FN3	914..1005	CDD:238020	32/94 (34%)
		FN3	1012..1101	CDD:238020	4/88 (5%)
		fn3	1106..1198	CDD:278470	22/95 (23%)
		PTPc	1476..1731	CDD:214550	185/254 (73%)
		PTPc	1503..1731	CDD:238006	162/227 (71%)
		PTPc	1763..2022	CDD:214550	208/258 (81%)
		PTPc	1791..2022	CDD:238006	191/230 (83%)
ptprf	XP_031756782.1	I-set	30..121	CDD:400151	46/93 (49%)
		Ig strand A	30..33	CDD:409353	1/2 (50%)
		Ig strand A'	39..42	CDD:409353	1/2 (50%)
		Ig strand B	47..54	CDD:409353	4/6 (67%)
		Ig strand C	60..65	CDD:409353	2/4 (50%)
		Ig strand C'	68..70	CDD:409353	1/1 (100%)
		Ig strand D	77..81	CDD:409353	2/3 (67%)
		Ig strand E	83..90	CDD:409353	3/6 (50%)
		Ig strand F	100..108	CDD:409353	5/7 (71%)
		Ig strand G	111..121	CDD:409353	3/10 (30%)
		IgI_2_RPTP_IIa_LAR_like	133..229	CDD:409400	45/95 (47%)
		Ig strand B	149..153	CDD:409400	1/3 (33%)
		Ig strand C	162..166	CDD:409400	1/3 (33%)
		Ig strand E	193..197	CDD:409400	2/3 (67%)
		Ig strand F	207..212	CDD:409400	4/4 (100%)
		Ig strand G	219..222	CDD:409400	0/2 (0%)
		IgI_3_RPTP_IIa_LAR_like	238..319	CDD:409401	49/81 (60%)
		Ig strand B	252..256	CDD:409401	2/3 (67%)
		Ig strand C	265..269	CDD:409401	2/3 (67%)
		Ig strand E	286..290	CDD:409401	3/3 (100%)
		Ig strand F	298..303	CDD:409401	4/4 (100%)
		Ig strand G	311..314	CDD:409401	0/2 (0%)
		FN3	322..411	CDD:238020	45/88 (51%)
		FN3	418..510	CDD:238020	43/91 (47%)
		FN3	515..603	CDD:238020	35/90 (39%)
		fn3	611..698	CDD:394996	30/86 (35%)
		FN3	713..818	CDD:238020	44/106 (42%)
		FN3	823..904	CDD:238020	20/87 (23%)
		fn3	921..1002	CDD:394996	30/85 (35%)
		fn3	1018..1077	CDD:394996	21/107 (20%)
		R-PTPc-F-1	1348..1623	CDD:350474	197/274 (72%)
		R-PTP-F-2	1626..1915	CDD:350477	227/288 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	418	1.000	Domainoid score	I643
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1246	1.000	Inparanoid score	I177
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	1	1.000	-	-		otm48333
Panther	1	1.100	-	-	O	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.150