DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and igsf9b

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_031761656.1 Gene:igsf9b / 100379858 XenbaseID:XB-GENE-5887265 Length:1392 Species:Xenopus tropicalis


Alignment Length:1033 Identity:211/1033 - (20%)
Similarity:344/1033 - (33%) Gaps:352/1033 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 TWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGTQSRYTVLE 87
            :|.|.|:  .|.|......||...|:.|...:..|.|.|:|.|::.|.:.|:.: |..|:|.:.:
 Frog   129 SWVHLTV--NAPPTFTETPPQYLEVKEGSSITLTCTAFGNPKPTVSWLREGEFL-GRTSKYQLSD 190

  Fly    88 QPGGISILRIEPVRAGRDD-APYECVAENGVGDAVSADATLTIYEGDKTPAGFPVITQGPGTRVI 151
              |.::|..|     ||:| ..|.|.|.:..|:||.:...|.        .|.|.|...|....:
 Frog   191 --GSLTISSI-----GREDRGSYMCRATSIQGEAVHSTRLLV--------QGSPFIVSPPENITV 240

  Fly   152 EVGHTVLMTCKA---IGNPTPNIYW------IKNQTKVDMSNPRYSLKDGFLQIENSREEDQGKY 207
            .:....|.||:|   .||.|...||      .||..|:.:.    .|.||.|.|...:.||.|||
 Frog   241 NISQDALFTCQAEAYPGNLTYTWYWQEENVFFKNDLKLRVR----ILIDGTLIIFRVKPEDAGKY 301

  Fly   208 ECVAENSMGTEHSKATNLYVK-------------------------VRRVPP-TF------SRP- 239
            .||..||:|...|.:..|.|:                         |..||| ||      .|| 
 Frog   302 TCVPSNSLGRSPSASAYLTVQYPARVVNMPPVIYVPVGIHGHIRCPVEAVPPVTFVKWNKDGRPL 366

  Fly   240 -----------------PETISEVMLGS------------------------------------- 250
                             .|..:|.:||:                                     
 Frog   367 RIDKFSGWKLLDDGTIHVEEATEELLGTYTCVPYNALGTMGQSPPARLLLKDPPYFTVLPGWEYR 431

  Fly   251 -----NLNLSCIAVGSPMPHVKWMK-GSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQ 309
                 .|.:.|.|.|.|.|.:.|.| |....:..:.:|.|....:.::.::...:.|:|::.:..
 Frog   432 QEAGRELLIPCAAAGDPFPSISWRKVGRPSFSKHSVLPSGSLQFRSLSKEDHGEWECVASNVVTS 496

  Fly   310 ID-SVSVVKVQSLPTAPTDVQISEVTATSVRLEW--SYKGPEDLQYYVIQYKPKNANQAFSEISG 371
            |. |..:..:.:.|.||::|:: .|:..:..:.|  .|.|              ...|.||...|
 Frog   497 ITASAHLTVIGTSPHAPSNVRV-VVSMNTANVSWEAGYDG--------------GFEQTFSVWYG 546

  Fly   372 II-------------------TMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFG 417
            .:                   :.:.:|.:|.|.|||:|.|:|.|.:|....|...|..|  .:|.
 Frog   547 ALIKRAQFGPHDWVSMPVPSGSSFLLVDSLDPETEYQFSVLAQNKLGTSSFSEVVTLRT--LAFP 609

  Fly   418 GTKME-----SAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDN 477
            .|..|     ::||.:.... :...::::|.||...:..:..|.:.:.....     |  :::|:
 Frog   610 LTTPEPLLVLTSPRCLTANR-TQQGVLLSWLPPSNHSFPLDRYIMEFRLAER-----W--EILDD 666

  Fly   478 SELTT-----VSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSN---------FRA 528
            |.|.:     ..||:....|..||.|                ..|.:.|:|||         |.:
 Frog   667 SILGSDTEILAKELSQDTWYEFRVLA----------------VMQDLISEPSNIAGVSSSDVFPS 715

  Fly   529 TDIGETAVT-----------------------------------LQWTKPTHSSENIVHYELYWN 558
            .|:.|....                                   ::..|.:||........:   
 Frog   716 PDLSEEGFARPVLAGIVATICFLAAAILFSTLAACVVNRQRKRKMKRKKVSHSCPTDPPLSI--- 777

  Fly   559 DTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEG--ATTPPIPVRTKQYGAPPRNIT 621
             |:..::....:|:.:      :.|:::..:...:.|...:|  :..|..|.|.|:.....:...
 Frog   778 -THCRKSMESPLSSGK------VSPESVRTLRAPSESSEDQGPPSKRPLSPGREKELSLYKKTKR 835

  Fly   622 AIATSSTTISL--SWLPPPVE----RSNGRIIYYKVFFVEVGREDDEATTMTLNMTSI----VLD 676
            |:.:...::|.  :.:..|:|    ..:||       ||..|.|.:.    ||....|    ..:
 Frog   836 AMTSKKYSVSQAEAEVTTPIELISRGPDGR-------FVTAGPEQEP----TLRSRRIQGFPFAE 889

  Fly   677 ELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGD-PQDVKA--TPLNST----------SI 728
            |...:.|::                      |.|...| |..:|:  |||:|:          |.
 Frog   890 ETDMYPEFR----------------------QSDEENDEPSGLKSQLTPLSSSQDSPLQPPAYSP 932

  Fly   729 HVSWKP------PLEKDRNGIIRGYHIHAQELRDEGKGFLNE---------PFKFDVVDTLEFNV 778
            ....:|      |..:.|.|   ||| |....     |:|:.         ||....|..|...:
 Frog   933 RFQHQPSEGRQQPSGQSRPG---GYH-HGHLY-----GYLSSSPLDSDPPPPFYMPEVSPLSSVM 988

  Fly   779 TG--LQPDTKY-----------SIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLK 823
            :.  |.|:..:           |.....||....|.||     ....|||..|.|.|:
 Frog   989 SSPPLLPEGSFPPIPEENGENSSTSTLPLTHTPTGGRS-----PEQWGVPDFPFVGLE 1041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845 28/94 (30%)
I-set 36..129 CDD:254352 27/93 (29%)
IG_like 146..227 CDD:214653 30/89 (34%)
Ig 159..228 CDD:299845 28/77 (36%)
I-set 234..318 CDD:254352 24/152 (16%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 16/111 (14%)
fn3 324..404 CDD:278470 22/100 (22%)
FN3 423..514 CDD:238020 16/95 (17%)
FN3 520..610 CDD:238020 17/135 (13%)
FN3 616..707 CDD:238020 15/100 (15%)
FN3 712..810 CDD:238020 30/138 (22%)
FN3 832..907 CDD:238020
FN3 914..1005 CDD:238020
FN3 1012..1101 CDD:238020
fn3 1106..1198 CDD:278470
PTPc 1476..1731 CDD:214550
PTPc 1503..1731 CDD:238006
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
igsf9bXP_031761656.1 IG 30..115 CDD:214652
I-set 139..225 CDD:400151 27/93 (29%)
Ig strand A 139..142 CDD:409353 1/2 (50%)
Ig strand A' 148..151 CDD:409353 0/2 (0%)
Ig strand B 157..164 CDD:409353 1/6 (17%)
Ig strand C 170..175 CDD:409353 1/4 (25%)
Ig strand D 185..189 CDD:409353 1/3 (33%)
Ig strand E 191..195 CDD:409353 1/3 (33%)
Ig strand F 204..212 CDD:409353 3/7 (43%)
Ig strand G 215..225 CDD:409353 3/9 (33%)
I-set 229..321 CDD:400151 32/95 (34%)
Ig strand B 246..250 CDD:409353 1/3 (33%)
Ig strand C 260..264 CDD:409353 1/3 (33%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 3/4 (75%)
Ig strand G 314..317 CDD:409353 1/2 (50%)
Ig 344..405 CDD:409353 12/60 (20%)
Ig strand C 355..360 CDD:409353 2/4 (50%)
Ig strand E 380..384 CDD:409353 0/3 (0%)
Ig strand F 394..399 CDD:409353 0/4 (0%)
Ig 429..505 CDD:416386 15/75 (20%)
Ig strand A' 429..432 CDD:409353 0/2 (0%)
Ig strand B 438..445 CDD:409353 2/6 (33%)
Ig strand C 451..456 CDD:409353 1/4 (25%)
Ig strand C' 458..460 CDD:409353 1/1 (100%)
Ig strand E 471..476 CDD:409353 1/4 (25%)
Ig strand F 484..492 CDD:409353 2/7 (29%)
Ig strand G 495..505 CDD:409353 2/9 (22%)
FN3 510..605 CDD:238020 25/109 (23%)
FN3 622..703 CDD:238020 19/104 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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