DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and ptprd

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_017209878.1	Gene:	ptprd / 100330629	-ID:	-	Length:	1944	Species:	Danio rerio

Alignment Length:	2118	Identity:	975/2118 - (46%)
Similarity:	1290/2118 - (60%)	Gaps:	271/2118 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QMTAARPIAALSLLVLS---LLTWTHPTIVDAAHPPEIIRKPQNQ-GVRVGGVASFYCAARGDPP 64
            ::..|.|....::|:|:   |||.       |..||:.:|.|.:| ||: ||||||.|.|.|||.
Zfish     5 RVCVALPSVRHTVLLLTACVLLTC-------AESPPKFLRTPSDQTGVQ-GGVASFICQASGDPR 61

  Fly    65 PSIVWRKNGKKVSGTQSRYTVLE-QPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLT 128
            |.|||.|.||:||  ..|:.|:| ..|..|:|||:|:|..||:|.|||||.|.||: .||...||
Zfish    62 PKIVWNKKGKRVS--NQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNSVGE-TSATTRLT 123

  Fly   129 IYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKD-- 191
            :...|:.|||||.|..||..:|:|...|..|.|.|.|||.|:|.|.|:...|:.|| ...:|.
Zfish   124 VLREDQLPAGFPTIDMGPQLKVVERTRTATMLCAASGNPDPDISWFKDFLPVNTSN-NGRIKQLR 187

  Fly   192 ----------GFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVK----VRRVPPTFSRPPET 242
                      |.||||.|.|.|||||||||.|:.||.:|...||||:    ||||||.||.|| |
Zfish   188 SESFGGTPIRGALQIEQSEESDQGKYECVATNNDGTRYSAPANLYVRELREVRRVPPRFSIPP-T 251

  Fly   243 ISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTL 307
            .:|:|.|.::|::|:|||||||:||||.||||||||::||||||||:|.::::||||||:|.|||
Zfish   252 DNEIMPGGSVNITCVAVGSPMPYVKWMLGSEDLTPEDDMPIGRNVLELTDVRQSANYTCVAMSTL 316

  Fly   308 GQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGI 372
            |.|::|:.:.|::||..|...|::|.||||:.|.|....||.:.||:||:||||:..:|.||.|:
Zfish   317 GVIEAVAQITVKALPKPPGVPQVTERTATSITLTWDSGNPEPVSYYIIQHKPKNSEDSFKEIDGV 381

  Fly   373 ITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSST 437
            .|..|.|..||||::|:|.|:|||||||||||......|.:     ....:|||.|:.|.||::|
Zfish   382 ATTRYSVGGLSPYSDYQFRVVAVNNIGRGPPSEDIEAKTAE-----QAPSTAPRQVRGRMLSATT 441

  Fly   438 MVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSM 502
            .:|.|:.||..|||:|||:|||||:.:|....|..|:|..|...|:..|||:..|.::|.|:||:
Zfish   442 AIIHWDEPEEANGQITGYRVYYTTDPSQHVNQWEKQIVRTSNFLTIPGLTPNKTYYIKVLAFTSV 506

  Fly   503 GAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSEN--IVHYELYWNDTYANQA 565
            |.||:|:.:|:.|:.||||||::|:.....||::.|.|..||.:.::  |:.|||.:..  .:..
Zfish   507 GDGPLSSDLQIIAKTGVPSQPTDFKGEAKSETSILLSWNPPTQTGQDNQIIGYELLYKK--GDDK 569

  Fly   566 HHKRIS--NSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATS 626
            ..||:|  .:..|.|..|.|.|.|...|||||:.|.||.|..|...|.|.  .|||:.:...:.|
Zfish   570 EEKRVSFEPTTTYLLKELKPFTTYMFQLAARSKHGIGAYTNEISAETPQTQPSAPPQEVKCTSHS 634

  Fly   627 STTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSI-------VLDELKRWTEY 684
            ||:|.:||.|||||..||.:..|.:.:.....:|    |....::.|       :|:.|::||||
Zfish   635 STSILVSWKPPPVELQNGIMTKYTIQYAATEGDD----TSMRQVSDIPPEKYHYLLENLEKWTEY 695

  Fly   685 KIWVLAGTSVGDGPRSHPIILRTQEDVP-GDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYH 748
            ::.|.|.|..|:||.|.|.::||:|||| |.|:.|:...:||||:.|.|:.|:...::|.||||.
Zfish   696 RVTVNAHTEAGEGPESLPQLIRTEEDVPSGPPRKVEVEAVNSTSVKVLWRSPVPSRQHGQIRGYQ 760

  Fly   749 IH-AQELRDEG------KGFLNEPFKFDVVDTLEFN--VTGLQPDTKYSIQVAALTRKGDGDRSA 804
            :| .:.:..|.      |..|.:..:::..|:.|..  ::.|..:|.||:.|||.|.||||.||.
Zfish   761 VHYVRMVNGEPVGHPVIKDILMDDAQWEYDDSAEHELVLSDLHAETTYSVTVAAYTTKGDGARSK 825

  Fly   805 AIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGP 869
            ..:|.|.|.||.:|.:   ::....:.:..|:|..|..|:|.|:|||||:|.||    .|.|:..
Zfish   826 PKLVTTTGAVPEKPRL---MVSPTNMGTALLQWHPPPNTFGPLQGYRLRFGRKD----VEPLTVI 883

  Fly   870 QMTKKR----FDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLC 930
            :.:::.    ...:.:|..|.||::..|.:|.|:||||...|||.||.|.|..|.....|...:.
Zfish   884 EFSERENHYTTKEIHKGASYTFRLSARNKVGFGEETVKEISTPEDTPAGYPQGIVAESSTTTTIQ 948

  Fly   931 VTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFT--NLEENTEYIFRVRAYTKQG 993
            |:|.|.....|||.:.:|.:|:.........||..:|..::..|  .|:.:|.|..::.|:|.:|
Zfish   949 VSWQPVALAERNGAVVKYALQYKDINSPRSPSELFITAPESTVTLDGLKADTTYDIKMCAFTSKG 1013

  Fly   994 AGPFSDKLIVETERDMGRA--PMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDD 1056
            .||:|..:...|: .:.:|  ..:....|..:.:..:.||...:......:.|.|        |:
Zfish  1014 PGPYSPSVQFRTQ-PVNQAVFAKNFHVRAAMKTSVLLTWEIPENYNPAQPFTILY--------DN 1069

  Fly  1057 WQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSM 1121
            .|:..|.                            |:|::|:.|.::||           :.:|.
Zfish  1070 GQSVEVD----------------------------GKLTQKLIVNLQPE-----------TQYSF 1095

  Fly  1122 TLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINEL---SPFTTY 1183
            .|:                        ::|.|...        |:|.|.|.|..::   .||...
Zfish  1096 LLT------------------------NRGNSAGG--------LQHRVSTMTAPDILRTKPFLIS 1128

  Fly  1184 NVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLV 1248
            ..|...                        ||..:..||...|.:..              ||:|
Zfish  1129 KTNADG------------------------MVTVELPGVQTAERVRA--------------YYIV 1155

  Fly  1249 VVPEDKS------NLHKIPDQFLTDDLLPGRNKPE-----RPN---APYIAAKFPQRSIPFTFHL 1299
            |||..|.      .|.:.||:...::||...|:..     |.:   .|||||.|  ..:|..|.|
Zfish  1156 VVPLKKQRPGKFIKLWENPDEMNLEELLREINRTSVSLRFRRHLELKPYIAACF--HELPNEFTL 1218

  Fly  1300 GSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSE---FLSLDMREAPPGERPHRPD 1361
            |....|..|.|::|...:.|..||.||::.....||.:||:|:   |..:|
Zfish  1219 GDAKMYGEFQNKQLLNGQEYVFFVLAVLEISDSMLYAASPYSDPVVFADID-------------- 1269

  Fly  1362 PNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMA 1426
                  |:..::   :|..::|||.|::...||:...:.:|.....:      ||:.........
Zfish  1270 ------PQPIID---EEEGLIWVVGPVLAVIFIICIVIAILLYKSSQ------PDRKRAESEARK 1319

  Fly  1427 ADLGAG---PT--PSDPVDMRRLNFQTPG--------------MISHPPIPISEFANHIERLKSN 1472
            ..|.:|   |:  |:|||::|||||||||              |.||||||:.|.|:||||||:|
Zfish  1320 GSLPSGKEMPSHHPTDPVELRRLNFQTPGSATSVYPSNLHLSRMASHPPIPVMELADHIERLKAN 1384

  Fly  1473 DNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCD 1537
            ||.|||||||||:|||||||::||||.||.|||||||.|||||||.|.|::|:.||||||:||.|
Zfish  1385 DNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIDGIPGSDYINSNYID 1449

  Fly  1538 GYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFV 1602
            ||||.|||:||||.|.|||.|||||.||.::|.||||||||||:|:|||||||.|||||||.|.|
Zfish  1450 GYRKQNAYIATQGALPETFGDFWRMIWEQRSANIVMMTRLEERSRVKCDQYWPNRGTETYGLIQV 1514

  Fly  1603 TITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESG 1667
            |:.:|.|||||.:|||.|.:.|.:::||::|.|||||||||||:||.|||.||||.::..||::|
Zfish  1515 TLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKSCNPPDAG 1579

  Fly  1668 PVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEA 1732
            |::||||||||||||:||||:||||:||||.:|||||||.:||||||||||||||:||||::.||
Zfish  1580 PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYVFIHDSLQEA 1644

  Fly  1733 IICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVH 1797
            :.||.||||||||:.::|||...|.||.::|||:|||:|:|.|..:|:|::|||||||.|||||:
Zfish  1645 VNCGTTEVPARNLYAYIQKLTQIESGENVTGMELEFKRLANTKAHTSRFISANLPCNKFKNRLVN 1709

  Fly  1798 ILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVM 1862
            |:||||:||.|.||.|:|||||:|.|||||||.:.||||.|||:.:..|||||||||||||||||
Zfish  1710 IMPYESTRVCLQPIRGVEGSDYINGSFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM 1774

  Fly  1863 LTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFID 1927
            ||||:|||||||.||||.|||.||||:||||:||||||||.||||||||||||.|||||||||.|
Zfish  1775 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTD 1839

  Fly  1928 WPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDV 1992
            |||||||||||||||||||||||||||||||||:|||||||||:|||||||||||||:||||:|:
Zfish  1840 WPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1904

  Fly  1993 FQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNY 2030
            ||||::||:||||||||||||.|||||.||||||||:|
Zfish  1905 FQTVKMLRTQRPAMVQTEDQYQFCYRAGLEYLGSFDHY 1942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	51/95 (54%)
		I-set	36..129	CDD:254352	50/94 (53%)
		IG_like	146..227	CDD:214653	40/92 (43%)
		Ig	159..228	CDD:299845	37/80 (46%)
		I-set	234..318	CDD:254352	52/83 (63%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	44/67 (66%)
		fn3	324..404	CDD:278470	42/79 (53%)
		FN3	423..514	CDD:238020	42/90 (47%)
		FN3	520..610	CDD:238020	34/93 (37%)
		FN3	616..707	CDD:238020	33/97 (34%)
		FN3	712..810	CDD:238020	37/107 (35%)
		FN3	832..907	CDD:238020	27/78 (35%)
		FN3	914..1005	CDD:238020	25/92 (27%)
		FN3	1012..1101	CDD:238020	12/90 (13%)
		fn3	1106..1198	CDD:278470	12/94 (13%)
		PTPc	1476..1731	CDD:214550	186/254 (73%)
		PTPc	1503..1731	CDD:238006	164/227 (72%)
		PTPc	1763..2022	CDD:214550	210/258 (81%)
		PTPc	1791..2022	CDD:238006	192/230 (83%)
ptprd	XP_017209878.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I3726
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1236	1.000	Inparanoid score	I178
OMA	1	1.010	-	-		QHG47937
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25136
orthoMCL	1	0.900	-	-		OOG6_100623
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.970