DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and ptprb

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001303656.1 Gene:ptprb / 100149130 ZFINID:ZDB-GENE-101108-3 Length:1892 Species:Danio rerio


Alignment Length:1879 Identity:415/1879 - (22%)
Similarity:676/1879 - (35%) Gaps:528/1879 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 PPSIVWR------KNGKKV-----SGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGV 117
            |||..|.      .||.:|     .|..::..:|   .|:::|   |.|..|    .....||| 
Zfish   312 PPSGEWEHIRVALSNGSEVLRNQTVGRTAKEILL---SGLNLL---PGRVYR----MAVSVENG- 365

  Fly   118 GDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDM 182
                 ..|...||||:   .|.|.::|      :.|.|:...:..|:        |....:.   
Zfish   366 -----GLANTVIYEGE---IGLPPVSQ------LHVRHSDETSLSAL--------WAHAASS--- 405

  Fly   183 SNPRYSLKDGFL---------QIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFS- 237
                 |.:||::         .:..:|...:...||                         ||: 
Zfish   406 -----SSRDGYIIQLFQSNTSTVIQTRNLSRDMREC-------------------------TFNV 440

  Fly   238 RPPETISEVMLGSNLNL---SCIAVGSPMP----HVKWM-KGSED-LTPENEMPIG--------- 284
            ..|..:.::.:.:...:   |....|...|    |:|.. |||.| |....|.|:|         
Zfish   441 LTPGRLYDITVTTTAKIIRSSATLQGRTQPLKVNHLKLSNKGSTDSLNASWEKPLGDLDFYHMLL 505

  Fly   285 -RNVLQLINIQESANYTC-------------IAASTL--GQIDSVSVVKVQSLPTAPTDVQISEV 333
             |:...:.||..|||.|.             |..:|:  .|...::..:.:::|.|.:|:.::..
Zfish   506 LRDQQTVHNITASANTTSRLLPFLRPGALHKILVTTISGSQTSKLAEAECRTVPAAVSDITVTNS 570

  Fly   334 TATSVRLEWSYKGPE-DLQYYVIQYKPKN-------ANQAFSEISGIITMYYVVRALSPYTEYEF 390
            ....:.:.|  |..| |:..||:..|.:.       .::|.:|.        |.|:|   .....
Zfish   571 GPDFLNVSW--KAAEGDVDNYVVMLKDQEKIVHTLATSKATTEC--------VFRSL---VSGRL 622

  Fly   391 YVIAVNNIGRGPPSAPATCTTGDFSFGGTKM---ESAPRNVQ----VRTLSSSTMVITWEPPETP 448
            |.|::              .|...|:....:   .:.|..||    :.:.....:.:.|      
Zfish   623 YSISI--------------ATHSGSYRNQTLLQERTKPSTVQNPTAIHSARDDFLKLYW------ 667

  Fly   449 NGQVTGYKVYYTTNSNQPEASWNSQMVDNSEL-TTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQ 512
             ...:|...||............||.::.::. ...|:|.|..:|.:.|..:    :|...:.|.
Zfish   668 -NHASGDYDYYVVTIEHNGTRLQSQKLNRTQSDCAFSDLVPGRLYNLTVSTW----SGQHYSAVS 727

  Fly   513 VKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYEL--YWNDTYANQAHHKRISNSEA 575
            :..:. .|....|...|:.|.|.:.:.||.   :..::.||||  .:|||..:.|    ::.|.|
Zfish   728 IYGRT-FPGAVGNLSLTERGGTFLRVSWTS---APGDVDHYELQILFNDTQVSAA----VNLSSA 784

  Fly   576 ---YTLDGLYPDTLYYIWLAARS---QRG---EGATTPPIPVRTKQYGAPPRNITAIATSSTTIS 631
               :....|.|..||.|.|:..|   ||.   ||.|.|. .|::....|        .|:..::.
Zfish   785 IGEHLFSALTPGRLYKIVLSTHSGSYQRAEILEGRTVPS-QVQSVHLSA--------GTADGSLR 840

  Fly   632 LSWLPPPVERSNGRIIYYKV-FFVEVGREDDEATTMTLNMT---SIVLDELKRWTEYKIWV--LA 690
            :||     ..::|.:.:|.| .|.|...:|.......:...   :::..:|     |.:.|  ::
Zfish   841 VSW-----SSADGDLDFYSVSLFQETHLQDSRRVPKHITQAEFYNLIPGQL-----YSVTVQSVS 895

  Fly   691 GTSVGDGPRSHPIILRTQEDVPGDPQDVKA-TPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQEL 754
            |:...:...:.    ||:   |.....::| ..|::.|:.|||.|.:     |:..||.:..  |
Zfish   896 GSQTNNSTTTG----RTE---PSTVTGLRADNELSTHSLLVSWNPAV-----GVHDGYRLWL--L 946

  Fly   755 RDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPT 819
            .|.|....|..........|..|:|   |..:|...|..|:...:.....|.....|..|.    
Zfish   947 DDGGTNIHNASVPAASRHHLFENLT---PGRRYQAHVRTLSGTAESKDVVAEGQTRPSAVS---- 1004

  Fly   820 VSLKIMEREPIVSIELE--WERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERG 882
             :|.:...   .|.:|.  |   |...|.:.||.|....:|:.|......|.......|..|:.|
Zfish  1005 -ALHVCSN---TSSDLSFCW---ASAVGWVDGYELYLYDRDETLHYHTTLGSDALGWSFTLLQPG 1062

  Fly   883 VEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITR 947
            ..|:..:...:.....|.:|.....|...   |..::..:.|| |.|.::|.|..     |.:|.
Zfish  1063 THYKMTITSKSGKLSNQSSVWAHTAPASV---PELHVENQGQT-DSLLLSWTPAP-----GGLTG 1118

  Fly   948 YDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETE---RDM 1009
            |.|....: :..:|.|    :.:.||.:|.....|:..|:.:        |:.|...|.   |.:
Zfish  1119 YSVTVDGR-EQRVGPE----VTQVVFHSLVAGRLYLATVQTW--------SEDLSNSTTAVGRTV 1170

  Fly  1010 GRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLE 1074
            ..||.|:....:.......|..|.|.                 |.:|::              :.
Zfish  1171 PAAPSSVSVSCSGGSVDMKWHVPDTG-----------------DYEDFE--------------VT 1204

  Fly  1075 KFAQYAVAIA-----ARFKNGL--GRL------------------SEKV--TVRIKPEDVPLNLR 1112
            .|.|..:.|:     .|...||  |||                  |..|  |:|..|...| ::.
Zfish  1205 WFPQDTLYISHLRPTQRILEGLHPGRLYNISLRTVSGKRHSPVTYSRPVYHTIRTPPLPAP-SIH 1268

  Fly  1113 AHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINE- 1176
            ...:|:.|::.||:||        ...:|...|....||..:.        :..|.:..||::: 
Zfish  1269 CFPLSSTSVSCSWTPP--------HSDYDGFVVQCHRQGSGKA--------VYTHTLGNHTLSQQ 1317

  Fly  1177 ---LSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEE 1238
               |.||..|.:.|:.:..| ......|.:|.|.:  .:|.|.|             :..:.:|.
Zfish  1318 FDRLEPFKNYTIYVAVMSGD-KQSSTVKNSVITMI--DRPPVPP-------------VTVRVNEH 1366

  Fly  1239 YGPISH--------------------YYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKPERPNAPY 1283
            ...|:|                    |:.::..|.....:.:|:|             ..|...|
Zfish  1367 SAVITHFTIRFKFNCSWFSDANGAIRYFTIIATESNDVDNGLPEQ-------------RHPLPSY 1418

  Fly  1284 I--------------------------------------------AAKFPQRSIPFTFHLGSGDD 1304
            :                                            |.|....||....||..|  
Zfish  1419 LDYRQNHSIKAYQTGYFHSTCAEGSDGKVQVFEINLGAGMKHLGGACKLDPESIQHGSHLCDG-- 1481

  Fly  1305 YHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPE 1369
                   .|.....||:.|||              |::....:.||.|   .|...|        
Zfish  1482 -------PLRSRTSYRLSVRA--------------FTQLFDEENREFP---HPLYTD-------- 1514

  Fly  1370 VSVNRNKDEPEILWVVLPLMVST--------------FIVSTALIVLCVVKRRRQPCKTPDQAAV 1420
                        .::.|||:..:              |:::..|.:..::..|::..|...|.: 
Zfish  1515 ------------TYLSLPLLTQSAPRSGLTGGITAALFLITMVLALTALLIYRKRAHKIAVQES- 1566

  Fly  1421 TRPLM-AADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESI 1484
              |:| .....|.||....:.:|            .|:..:.|.:|:.:|:|:.:...|:|:|.:
Zfish  1567 --PVMKMCKWKALPTSQMCLRIR------------SPVQAANFESHLAKLQSDSSYLLSEEFEGL 1617

  Fly  1485 -EPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVAT 1548
             :.|:..|.:.:.|..|::||||.|:..||.:||:|..:|....||||||||..|......|:||
Zfish  1618 KDVGRIQTQNAARLLGNRNKNRYNNILPYDSTRVRLSCLEDDPCSDYINANYIPGNNFRWEYIAT 1682

  Fly  1549 QGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTE-TYGQIFVTITETQELAT 1612
            ||||..|..|||||.||....::||:|:..||..:|||.||||.... .||.|.|.:...:....
Zfish  1683 QGPLPGTKDDFWRMVWEQNVHSLVMVTQCVERGMVKCDHYWPTDSEPLCYGDIVVQLLSEKVFPE 1747

  Fly  1613 YSIRTFQL-CRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGP--VIVHCS 1674
            ::||.|:: |.......|.::|..:|.||||||||.....:||:|..|......:.|  .:||||
Zfish  1748 WTIRDFKISCESQLRYPRMVRQFHYTIWPDHGVPDTTQSLIQFVRTVRDFINRTNSPGISVVHCS 1812

  Fly  1675 AGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI 1733
            |||||||.:||:|..|:::.....:||||.|..||..|:||||||.||.:||..:.:.:
Zfish  1813 AGVGRTGTFIVLDRALQQLDRNCTVDIYGCVFDLRLHRSYMVQTECQYAYIHQCVRDVL 1871

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845 18/75 (24%)
I-set 36..129 CDD:254352 18/75 (24%)
IG_like 146..227 CDD:214653 10/89 (11%)
Ig 159..228 CDD:299845 8/77 (10%)
I-set 234..318 CDD:254352 26/118 (22%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 23/101 (23%)
fn3 324..404 CDD:278470 16/87 (18%)
FN3 423..514 CDD:238020 16/95 (17%)
FN3 520..610 CDD:238020 31/100 (31%)
FN3 616..707 CDD:238020 13/96 (14%)
FN3 712..810 CDD:238020 23/98 (23%)
FN3 832..907 CDD:238020 17/76 (22%)
FN3 914..1005 CDD:238020 20/90 (22%)
FN3 1012..1101 CDD:238020 20/115 (17%)
fn3 1106..1198 CDD:278470 20/95 (21%)
PTPc 1476..1731 CDD:214550 111/259 (43%)
PTPc 1503..1731 CDD:238006 104/231 (45%)
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
ptprbNP_001303656.1 FN3 113..199 CDD:238020
fn3 216..276 CDD:306538
FN3 290..366 CDD:328772 17/69 (25%)
fn3 380..453 CDD:306538 15/119 (13%)
fn3 561..632 CDD:306538 17/97 (18%)
FN3 647..727 CDD:328772 14/90 (16%)
fn3 735..808 CDD:306538 22/79 (28%)
fn3 823..896 CDD:306538 14/91 (15%)
fn3 911..990 CDD:306538 21/88 (24%)
FN3 1001..1081 CDD:328772 18/90 (20%)
fn3 1090..1154 CDD:306538 18/77 (23%)
FN3 <1190..1246 CDD:328772 14/86 (16%)
fn3 1263..1340 CDD:306538 20/94 (21%)
PTPc 1637..1867 CDD:238006 104/229 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.