DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and csf3r

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_001106848.1	Gene:	csf3r / 100134935	ZFINID:	ZDB-GENE-080104-4	Length:	810	Species:	Danio rerio

Alignment Length:	830	Identity:	169/830 - (20%)
Similarity:	278/830 - (33%)	Gaps:	262/830 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 VMLGSNLNLSC-IAVGSPMP-----HVKWMKGSEDLTP------ENEM----------PIGRNVL 288
            |:.||.:::|| |....|:.     :|:|....: :.|      |:.|          ....::|
Zfish    36 VLAGSPVSVSCSIEEDCPLTKGKVFYVQWRIDGQ-VVPRTYTYQESNMTYSVLIPRLQDTSASIL 99

  Fly   289 QLINIQESA-----------------NYTCIAASTLGQIDSVSV--VKVQSLPTAPTDVQISEVT 334
            .|:.:||..                 |.:|  |.||.::.|:..  ..||.:...|.:..:....
Zfish   100 CLVCVQEDCQIVDGVEVKTGNPPVPQNLSC--ALTLVKMPSLRCDWNPVQEIKNLPINYTLHVFR 162

  Fly   335 ATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIG 399
            |.|.::   |..|....:||:   |::|...|||:...:|   ....|...|.....:..:|.:.
Zfish   163 AKSQKV---YAVPPGQHFYVV---PRDAYGYFSELEISVT---AANVLGNTTSDPLKLTPLNTVK 218

  Fly   400 RGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNG-QVTG-YKVYYTTN 462
            ..|||.             |::|:.         ....:..:|...||... |:|. .::...|.
Zfish   219 FDPPSI-------------TRIEAH---------KYGCLKYSWSLSETQKWLQLTFIVQLRLKTV 261

  Fly   463 SNQPEASWNSQMVDNSELTTVS---ELTPHAI----------YTVRVQAYTSMGAGPMSTPVQVK 514
            ||||          |.:|...|   :|.|..:          .||||:.|.:......|.|
Zfish   262 SNQP----------NKDLVYTSRQLQLNPIEVCSLLHWTDYRSTVRVKYYATSEWSEWSDP---- 312

  Fly   515 AQQGVPSQPSNFRATDIGETAVTLQ---------WTKPTHSSENIVHYELYWNDTYANQAHHKRI 570
                              :||.||.         |.|..:.:.     :|||..:...:|:.:.:
Zfish   313 ------------------KTATTLNKAPAGRLDTWLKVNNQTA-----QLYWKPSQQFRANGQNL 354

  Fly   571 SNSEAYTLDG------LYPDTLYY-----------IWLAARSQRG-EGATTPPIPVRTKQYGAPP 617
            |    |::|.      |...|..|           |:|.||::.| ......|:.|...:...|.
Zfish   355 S----YSVDSKDTKKRLCVTTETYCFFSLTKWDKKIFLRARNEVGFSDHNEVPVAVHRNKGLEPV 415

  Fly   618 RNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATT-----MTL---NMTSIV 674
            .|.:....|:|::.:.|..|........::.::...         .||     .||   |.::..
Zfish   416 SNFSVHPQSNTSLHVIWKSPAFSNVTSYVLEWRSLC---------GTTAAPLSFTLIHKNKSNTT 471

  Fly   675 LDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSW-KPPLEK 738
            |..|:....|:|.:......|.| |...::..:.|..|.|..::....::.:.:...| :.||||
Zfish   472 LTGLEPSKPYEISIYPRYVKGIG-RPVTVLAYSSETAPSDAPELNYEEISRSHLKFHWGQIPLEK 535

  Fly   739 DRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKG----- 798
             |||||:||..:....::|.|..:......:|.|        |||.|||...::..|:.|
Zfish   536 -RNGIIQGYRFYFWHNKNEIKEIMTTETSVEVKD--------LQPHTKYHALLSICTKGGCVNGS 591

  Fly   799 ---------DG--------------DRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERP 840
                     ||              .....|:|.|..|...|..:.|..:..:|..|....|
Zfish   592 FSTLTTERLDGIEMVIFVIPACIGASLLVIIIVFTCFGKQERVKMCLWPIIPDPANSSIKRW--- 653

  Fly   841 AQTYGELRG-------------YRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGS 892
             .|...|:|             |.....:.|...||...||.....:..|:|....:.:     |
Zfish   654 -TTTDSLQGLPAFKEDKDPVLVYLSHLSLLDMTEKEPFKSGYVKENQWPDDLNIHADTQ-----S 712

  Fly   893 NHIGIGQETVK----IFQTP--------------EGT--------PGGPP 916
            ..:.:.:|:|.    :|.||              |.|        ||.||
Zfish   713 CDLELERESVPYATVLFSTPYQINSSNPPAYVRSESTQPLLAGDEPGSPP 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352	22/112 (20%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	21/108 (19%)
		fn3	324..404	CDD:278470	17/79 (22%)
		FN3	423..514	CDD:238020	22/105 (21%)
		FN3	520..610	CDD:238020	23/116 (20%)
		FN3	616..707	CDD:238020	18/98 (18%)
		FN3	712..810	CDD:238020	30/126 (24%)
		FN3	832..907	CDD:238020	17/91 (19%)
		FN3	914..1005	CDD:238020	2/3 (67%)
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470
		PTPc	1476..1731	CDD:214550
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
csf3r	NP_001106848.1	Lep_receptor_Ig	25..102	CDD:283889	13/66 (20%)
		FN3	414..494	CDD:214495	16/88 (18%)
		FN3	508..597	CDD:238020	26/97 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910