DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and ptprm

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_031759627.1 Gene:ptprm / 100127701 XenbaseID:XB-GENE-5958903 Length:1486 Species:Xenopus tropicalis


Alignment Length:1760 Identity:481/1760 - (27%)
Similarity:719/1760 - (40%) Gaps:487/1760 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   429 QVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTN--SNQPEASWNSQMVDNSE--------LTTV 483
            ||.||...|     ..|..|:|   .:.:..||.  :.|....:..|:.:|..        :::.
 Frog    51 QVNTLLKPT-----SDPWMPSG---SFMMVNTTGRFAGQRSVLYLPQLKENDTHCIDFHYFVSSK 107

  Fly   484 SELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIG-----ETAVTLQWTKP 543
            |...|.:     :..|.::..|||..||.            |...:..|     |.|:::.|.: 
 Frog   108 SGALPGS-----MNIYVTVNNGPMGNPVW------------NISGSATGTWNRAELAISIFWPR- 154

  Fly   544 THSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLA-ARSQRGEGATTPPIP 607
                    .|::|:....::|  |..::..|...|....|.|.:::.:. .....|:.||.    
 Frog   155 --------FYQVYFEVITSDQ--HGYLAIDEVKVLGHPCPKTPHFVHVQNVDVNAGQSATF---- 205

  Fly   608 VRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTS 672
                       ..||...:|....| ||    :.:|||:...|...|:..|. ..||...:|.|.
 Frog   206 -----------QCTANGKTSAMDRL-WL----QGANGRVAPLKDIKVQNIRR-FVATFNVVNTTK 253

  Fly   673 IVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVP-GDPQDVKATPLNSTSIHVSWKPPL 736
                  |....|:..|  .|..|.|..::..::..:..|| ..||      |:|......|    
 Frog   254 ------KDAGNYRCMV--RTEAGVGVSNYAELIVKEPPVPIAPPQ------LSSVGATYMW---- 300

  Fly   737 EKDRNGIIRGYHIHAQELRDEGKGFLNEP---------FKFDVVDTLEFNVTGLQPDTKYSIQVA 792
                      ..::...:..:|...|.|.         :...|||:..:.:..|.|||:|.|.| 
 Frog   301 ----------IQLNTNSINGDGPIILKEVEYHTVSGSWYDIQVVDSNIYKIGHLDPDTEYEISV- 354

  Fly   793 ALTRKGDGDRSA---AIVVKTPGGVPVRPTVSLKIMEREPIVS--IELEWERPAQTYGELRGYRL 852
            .|||.|:|.|.:   |:..:|....|:.....|:::|   |.|  |.:.|| |.       ||  
 Frog   355 LLTRPGEGGRGSPGPALRTRTKCADPMHGPRKLQVVE---IKSRQITIRWE-PF-------GY-- 406

  Fly   853 RWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPS 917
                                     |:.|...|...:.....:| |||.|:    .|        
 Frog   407 -------------------------NVTRCHRYNLTILYKYQVG-GQEQVR----EE-------- 433

  Fly   918 NITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEY 982
                         |:||..: .|....||            .|....|::: |.|..|.|...| 
 Frog   434 -------------VSWDTES-SHPQHTIT------------NLTPFTNVSV-KLVLMNPEGRKE- 470

  Fly   983 IFRVRAYTKQGAGPFSDKLIVETERDM-GRAPM-SLQAEATSEQTAEIWWEPVTSRGKLLGYKIF 1045
                           |.:|||:|:.|: |..|: |||:....|:....|.||..:.|.:..|:|.
 Frog   471 ---------------SQELIVQTDEDVPGAVPLESLQSSTFEEKIFLQWREPAQTYGIITLYEIT 520

  Fly  1046 YTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLN 1110
            |             |.|.                                               
 Frog   521 Y-------------KAVS----------------------------------------------- 525

  Fly  1111 LRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTIN 1175
                         |:.|.|.|:    |.|...:|     || ::|           ||:    ..
 Frog   526 -------------SFDPEIDLS----KQSGQDIK-----QG-NET-----------HYL----FF 552

  Fly  1176 ELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQ--------PMVKPDFYGVVNGEEILVIL 1232
            .|.|.|||:..:.|..:. .:.|......||:::||.        |:.:.|       ..:.|:|
 Frog   553 GLYPGTTYSFTIKASTAK-GFGPAITSQFTTRISAPSMPAYELETPLNQTD-------STVTVML 609

  Fly  1233 PQASEEYGPISHYYLVVVPEDKSNLHK----------IPDQFLTDDLLPGRNKPERPNAPYIAAK 1287
            ..|.....|:| .|.|:|.|::....|          :|..:....||..:.        |.||:
 Frog   610 KPAQSRGAPVS-VYQVIVEEERPRRTKKTTEMLKCYPVPIHYQNSSLLNSQY--------YFAAE 665

  Fly  1288 FPQRSI--PFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAV-------------VDTPQKHLYT- 1336
            ||..|:  ...|.:|....|:.:.|..|...|.|.|:.:|.             :.|....:.| 
 Frog   666 FPPSSLLSSLLFTIGDNKTYNGYWNTPLLPHKSYSIYYQAASRANGETKIDCVRIATKAAIIVTQ 730

  Fly  1337 -SSPFSEFLSLDMREAP-------PGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTF 1393
             ::|:       :|.||       .|....:||....::.:.:|   |....|..::|      |
 Frog   731 LTTPY-------IRIAPAAGDDQLTGAATSKPDSEHESQSDHTV---KIAGGIAGILL------F 779

  Fly  1394 IVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMA----------ADLGAG---------------- 1432
            ::....:|| |:|:|:...|..:..:.||..|.          .:.|..                
 Frog   780 VIIFLGVVL-VMKKRKLAKKRKETLSNTRQEMTVMVNSMDKSYTEQGTNCDEAFSFMDTHNLNGR 843

  Fly  1433 ------------------------PTP---------------------------SDPVDMRRLNF 1446
                                    |.|                           .||||   :.:
 Frog   844 SVSSPSSFTMKTNTLSTTVPNSYYPDPFVPTAILDENHTNSETSSLAQPHTYKKRDPVD---IPY 905

  Fly  1447 QTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTA 1511
            || |.: ||.|.:::...||.::|..:...|.:|||:...||...|:::..:.|:.||||.|:.|
 Frog   906 QT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYETFFEGQSAPWESAKKDENRMKNRYGNIIA 968

  Fly  1512 YDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTR 1576
            ||||||:|.::|....|||||.||.|||.:.|.|:|||||:|||..|||||.|...||:|||:|.
 Frog   969 YDHSRVRLQSIEDEASSDYINGNYVDGYHRPNHYIATQGPMQETVYDFWRMIWHENTASIVMVTN 1033

  Fly  1577 LEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPD 1641
            |.|..|:||.:|||. .||.|..|.||:.||:.||.|.||||.:.::|.::.|||:|..||.|||
 Frog  1034 LVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPD 1097

  Fly  1642 HGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVT 1706
            ||||.|....|.|:|:.::..||.|||::||||||.|||||:||||.||:..:.|.::|||..|.
 Frog  1098 HGVPYHATGLLGFVRQVKSKNPPNSGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVR 1162

  Fly  1707 CLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKL 1771
            .||::|..|||||:||:|||||||||.:||.|.:.|..:.:...::...:|....|.::.||:.|
 Frog  1163 ELRSRRVNMVQTEEQYVFIHDAILEACLCGDTAILASQVRSVYYEMNKVDPQTNSSQIKEEFRTL 1227

  Fly  1772 SNVK-----MDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYR 1831
            :.|.     .|.|   .|.||.|..|||.:.:||.:....:|..|.| |.|:|:||:.:|.|...
 Frog  1228 NMVTPTLRVEDCS---IALLPRNHEKNRCMDVLPPDRCLPFLITIDG-ESSNYINAALMDSYVQP 1288

  Fly  1832 SAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRY---QYYVVDP 1893
            ||:|..|.|:.:..:||||::.:::.|.:|||..:..  .:.|.||||.....|:   |...|..
 Frog  1289 SAFIVTQHPLPNTVKDFWRLVLDYHCTSIVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSA 1351

  Fly  1894 IAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQ 1956
            ..|.::.....|.:..:..:|| .|.|:||||:.|| .:..|.|...|:..|.||.|.:|:: |.
 Frog  1352 DLEEDIISRIFRIYNASRPQDG-YRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGG 1415

  Fly  1957 DGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAAL 2021
            :|...|||..|.||||.|..:||:.|.:.::..:|||..|:.||:.:|.||...|||.|||..||
 Frog  1416 EGRTVVHCLNGGGRSGTFCAISIICEMLHHQRAVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVAL 1480

  Fly  2022 EYLGS 2026
            |||.|
 Frog  1481 EYLNS 1485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628 66/334 (20%)
FN3 712..810 CDD:238020 26/110 (24%)
FN3 832..898 CDD:214495 11/67 (16%)
FN3 <867..1269 CDD:442628 79/421 (19%)
fn3 914..998 CDD:394996 13/83 (16%)
R-PTPc-LAR-1 1498..1735 CDD:350401 134/236 (57%)
R-PTP-LAR-2 1784..2021 CDD:350402 89/241 (37%)
ptprmXP_031759627.1 MAM 23..183 CDD:214533 32/167 (19%)
ig 193..275 CDD:395002 25/110 (23%)
Ig strand B 203..207 CDD:409359 2/18 (11%)
Ig strand C 219..223 CDD:409359 3/8 (38%)
Ig strand F 258..263 CDD:409359 1/4 (25%)
Ig strand G 272..275 CDD:409359 0/2 (0%)
FN3 283..362 CDD:214495 24/99 (24%)
FN3 384..478 CDD:238020 36/187 (19%)
fn3 481..574 CDD:394996 34/191 (18%)
R-PTPc-M-1 918..1190 CDD:350481 144/272 (53%)
R-PTPc-M-2 1276..1481 CDD:350483 76/207 (37%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.