DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and ptprdb

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_021330723.1	Gene:	ptprdb / 100073332	ZFINID:	ZDB-GENE-070615-38	Length:	1955	Species:	Danio rerio

Alignment Length:	2119	Identity:	930/2119 - (43%)
Similarity:	1256/2119 - (59%)	Gaps:	269/2119 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TAARPIAALSLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQ-GVRVGGVASFYCAARGDPPPSIVW 69
            :|.:|:.   |::||.|...|   :.:|  |...|.|.:| ||: ||||||.|.|.|||.|.|.|
Zfish    10 SAYQPVL---LILLSALQLAH---MQSA--PRFTRTPTDQIGVQ-GGVASFVCQATGDPQPKITW 65

  Fly    70 RKNGKKVSGTQSRYTVLE-QPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGD 133
            .:.||||  |..|:.|:| :.|..|.||::|:|..||:|.|||||.|.:|: ::|...|::...|
Zfish    66 SRKGKKV--TNQRFEVIEFEDGSGSALRVQPLRTPRDEAIYECVASNEIGE-ITASTRLSVLRED 127

  Fly   134 KTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKD------- 191
            :.|||||.|..||..:|:|...|..|.|.|.|.|.|.|.|.|:...:| ::....:|.
Zfish   128 QLPAGFPSIDMGPQLKVVERSRTATMLCAASGTPDPEITWFKDFLPID-THTHGRIKQLRSESFG 191

  Fly   192 -----GFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVK----VRRVPPTFSRPPETISEVM 247
                 |.|||:.|.|.|||||||||.||.||.:|...||||:    |||:||.||.||... |:|
Zfish   192 GTPIRGALQIDQSEETDQGKYECVATNSEGTRYSTPANLYVRELRDVRRIPPRFSVPPMDY-EIM 255

  Fly   248 LGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDS 312
            .|.::|::|.|||.|||:||||.|:||||||::||||||||:|.|:::||||||:|.||||.|::
Zfish   256 PGGSVNITCQAVGVPMPYVKWMLGAEDLTPEDDMPIGRNVLELTNVRQSANYTCVAMSTLGVIET 320

  Fly   313 VSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYY 377
            |:.:.|::||..|....:.|.:|||:.|.|....|..:.||:|||:|.::...|.||..|.|..|
Zfish   321 VAQITVKALPNPPGSPVVMERSATSITLMWDSGNPHPVSYYIIQYRPSSSTDPFKEIDAIATTRY 385

  Fly   378 VVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITW 442
            .|..||||:.|.|.|:|||:||||.||......|.:     ....|.||.|:.|.||.||.::.|
Zfish   386 SVGGLSPYSHYHFRVVAVNSIGRGAPSPTVDARTAE-----QAPSSPPRRVRGRMLSGSTAMVQW 445

  Fly   443 EPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPM 507
            |.||..||||.||:||||::|:...:.|..:||..:....:.:|||:..|.:||.|:|::|.||:
Zfish   446 EEPEEANGQVVGYRVYYTSDSSLSVSQWEKEMVRGANFLNIRDLTPNKTYYIRVLAFTAVGDGPL 510

  Fly   508 STPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHS-SENIVHYELYWNDTYANQAHHK-RI 570
            |:.:.:.|:.||||||:..:|....||::.|.|..|.|| ::.|..|||.:.  ..:|...| ..
Zfish   511 SSDLHIIAKTGVPSQPTELKAEVKSETSILLSWIPPAHSGTDAITGYELIYR--LGDQPEQKITF 573

  Fly   571 SNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGA--PPRNITAIATSSTTISLS 633
            ..|.:|.|..|.|.:.|...|||||:.|.||.|..|.|:|.|..:  ||:::|..:.|||::.||
Zfish   574 DPSSSYLLKNLKPFSTYVFQLAARSKHGLGAFTSEITVQTPQTQSIPPPQDVTCTSPSSTSLLLS 638

  Fly   634 WLPPPVERSNGRIIYYKVFFVEVGREDD---EATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVG 695
            |..||.: .||.:..|.:.:|.|.|:.|   :.:.:..|.....::.||:.|.|.:.:.|.|..|
Zfish   639 WASPPTD-ENGIVTGYSIRYVAVERDKDPVQKISDIPSNCFRYRIEGLKKGTLYSVTIAAHTDNG 702

  Fly   696 DGPRSHPIILRTQEDVP-GDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHI-HAQELRDE- 757
            .||.|.||::||:|||| ..|:.|....||:||..||||||:.:.::|.|||:.: :|:....|
Zfish   703 QGPESLPILVRTEEDVPSAPPRGVDVVVLNATSARVSWKPPVAERQHGKIRGFQVTYARRTAGER 767

  Fly   758 ------GKGFLNEPFKFDVVDTLEFNV--TGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGV 814
                  .:..|.:| :....|::|..|  |.|.|:|:||:.|||.|.||||.||..||::|...:
Zfish   768 TVSPRIREHLLRDP-QQPQNDSIEHEVILTDLWPNTEYSVTVAAFTSKGDGARSKPIVIRTKPSL 831

  Fly   815 PVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRF--D 877
            |..|.  |.::..|...:: |:|:.|......:.||||.:|..|.:....|:......::.:  .
Zfish   832 PGMPL--LTVVSSEDSTAL-LKWQPPPTGLSPVLGYRLSYGQADPSSDTFMVQELDAEERSYTVS 893

  Fly   878 NLERGVEYEFRVAGSNHIGIG---QETV---KIFQT--------PEGTPGGPPS---------NI 919
            :|..||.|.||:|.....|.|   |.|:   .:.||        |..|.|...|         |:
Zfish   894 SLSAGVLYVFRLAARTVWGYGSSAQVTLLIPNVVQTTTDGMITDPMTTEGQTMSVQENVPILANL 958

  Fly   920 TIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHG--LGSERNMTLRKAVFTNLEENTEY 982
            |..........:.|:.|  ::.:| |..|.|.|.....:|  :..|.:::....|...|..||||
Zfish   959 TAESINSSSAILRWERP--KNYDG-IQGYRVWFAVTYSNGTDIAMESDVSETTVVLHGLRANTEY 1020

  Fly   983 IFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYT 1047
            :.||...:|||.||:|..:.::|:.......::.:.:|..:.:..:.||..|:..|.....|.|
Zfish  1021 VARVCMLSKQGPGPYSLPISIKTQPAEEVFAVNFKVKAAMKSSVLLTWESRTTSNKAQSLIISY- 1084

  Fly  1048 MTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLR 1112
                           |..||.::.                    |||.:|:..::||:.:
Zfish  1085 ---------------GDGESVEVD--------------------GRLGQKLVTKLKPQSL----- 1109

  Fly  1113 AHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINEL 1177
                                 .|:.::..:     ||.|..|.:
Zfish  1110 ---------------------YNFLLTSKS-----DSTGGLQHR--------------------- 1127

  Fly  1178 SPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMV-KPDFYGVVNGEEILVILPQASEEYGP 1241
                                       |..|.||..|. ||......:.:.|.::.....:....
Zfish  1128 ---------------------------TDAMTAPNLMTRKPQLLDKTSSQSIAILQLPTVQGQAN 1165

  Fly  1242 ISHYYLVVVPEDK------SNLHKIPDQFLTDDLL-----PGRNKPERPNA---PYIAAKFPQRS 1292
            :..:|::|||..:      .|:...||:...|:||     .||:...|..|   |||.|.|  ::
Zfish  1166 VRGFYILVVPLKRQRAGNFQNMWSDPDEMNLDELLREINGTGRSVRLRRQAEAKPYITAHF--QN 1228

  Fly  1293 IPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERP 1357
            :|..|.||.|..|..|.||.|...:.|..||.|:::..|..:|::||||:.:...
Zfish  1229 LPAEFKLGDGHVYGAFMNRPLVNGQEYVCFVLAILELGQNTVYSTSPFSDAVLFS---------- 1283

  Fly  1358 HRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVK---RRR-----QPCKT 1414
                   ..||:..|:   :|..:||||.|::...||:|..:::|....   |:|     :.|..
Zfish  1284 -------DVEPQPIVD---EEEGLLWVVGPVLAVIFIISIVILILLFKSKPDRKRAELEGRKCSF 1338

  Fly  1415 PDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQ 1479
            |......         :...|||||::||:||.|.||.||||:.:||...||||:|:||:.:|||
Zfish  1339 PSSGKAM---------SSQHPSDPVELRRINFPTAGMTSHPPVSVSELPAHIERMKANDSLRFSQ 1394

  Fly  1480 EYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNA 1544
            |||||:|||||:|::||||.||.|||||||.||||:||.|...:||.|.||||||:.||||:..|
Zfish  1395 EYESIDPGQQFSWEHSNLEINKPKNRYANVIAYDHTRVALTNTDGVAGGDYINANFIDGYRRQGA 1459

  Fly  1545 YVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRI--------KCDQYWPTRGTETYGQIF 1601
            |:|||||:.:||.|||||.||..||.::|:|:|||::|:        |||||||:|||||||.:.
Zfish  1460 YIATQGPMPDTFSDFWRMVWEQHTANVIMITKLEEKSRMPSYFFSKNKCDQYWPSRGTETYGLMQ 1524

  Fly  1602 VTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPES 1666
            |::.:|.|||||.:|||.|.:.|..::||::|.|||||||.|||:||.|||.||||.:|..||::
Zfish  1525 VSLLDTVELATYCVRTFALFKSGSGEKREVRQFQFTAWPDQGVPEHPTPFLAFLRRVKACNPPDA 1589

  Fly  1667 GPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE 1731
            ||::||||||||||||:||||:||||:|.||.:|||||||.:|:|||||||||:||:||::|:||
Zfish  1590 GPIVVHCSAGVGRTGCFIVIDAMLERVKQEKTLDIYGHVTLMRSQRNYMVQTEEQYVFIYEALLE 1654

  Fly  1732 AIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLV 1796
            |:.||.||||||||:.::|:|..|||.|.|||||.|||:|:|.|..:|:||:|:|||||.|||||
Zfish  1655 AVSCGNTEVPARNLYAYIQRLSQTEPPEHISGMEQEFKRLANAKAHNSRFVSASLPCNKFKNRLV 1719

  Fly  1797 HILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVV 1861
            :|:||||:||.|.||.|:|||||||.|||||||.:.||||.|||:.:..||||||||||||||||
Zfish  1720 NIMPYESTRVCLQPIRGVEGSDYVNGSFIDGYRQQRAYIATQGPLAETVEDFWRMLWEHNSTIVV 1784

  Fly  1862 MLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFI 1926
            |||||:|||||||.||||.:||.||||:||||:||||||||.||||||||||||.|||||||||.
Zfish  1785 MLTKLREMGREKCHQYWPSDRSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFT 1849

  Fly  1927 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLD 1991
            ||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||:||||:|
Zfish  1850 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVD 1914

  Fly  1992 VFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNY 2030
            :||||::||:|||||||||:||.|||||.||||||||:|
Zfish  1915 IFQTVKMLRTQRPAMVQTEEQYQFCYRAGLEYLGSFDHY 1953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	46/95 (48%)
		I-set	36..129	CDD:254352	46/94 (49%)
		IG_like	146..227	CDD:214653	37/92 (40%)
		Ig	159..228	CDD:299845	34/80 (43%)
		I-set	234..318	CDD:254352	50/83 (60%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	43/67 (64%)
		fn3	324..404	CDD:278470	35/79 (44%)
		FN3	423..514	CDD:238020	39/90 (43%)
		FN3	520..610	CDD:238020	35/91 (38%)
		FN3	616..707	CDD:238020	31/93 (33%)
		FN3	712..810	CDD:238020	42/108 (39%)
		FN3	832..907	CDD:238020	21/82 (26%)
		FN3	914..1005	CDD:238020	26/101 (26%)
		FN3	1012..1101	CDD:238020	14/88 (16%)
		fn3	1106..1198	CDD:278470	5/91 (5%)
		PTPc	1476..1731	CDD:214550	169/262 (65%)
		PTPc	1503..1731	CDD:238006	149/235 (63%)
		PTPc	1763..2022	CDD:214550	210/258 (81%)
		PTPc	1791..2022	CDD:238006	192/230 (83%)
ptprdb	XP_021330723.1	I-set	32..123	CDD:254352	46/94 (49%)
		Ig2_RPTP_IIa_LAR_like	151..233	CDD:319301	34/82 (41%)
		Ig3_RPTP_IIa_LAR_like	257..325	CDD:143216	43/67 (64%)
		FN3	330..419	CDD:238020	38/88 (43%)
		FN3	426..517	CDD:238020	39/90 (43%)
		FN3	523..613	CDD:238020	35/91 (38%)
		fn3	620..707	CDD:306538	28/87 (32%)
		FN3	722..827	CDD:238020	41/105 (39%)
		FN3	829..920	CDD:238020	24/93 (26%)
		FN3	957..1043	CDD:238020	25/88 (28%)
		PTPc	1417..1654	CDD:238006	149/236 (63%)
		PTPc	1686..1945	CDD:214550	210/258 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	418	1.000	Domainoid score	I627
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H88669
Inparanoid	1	1.050	1236	1.000	Inparanoid score	I178
OMA	1	1.010	-	-		QHG47937
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	1	1.000	-	-		otm25136
orthoMCL	1	0.900	-	-		OOG6_100623
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970