DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lar and ptprs

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_001135464.1	Gene:	ptprs / 100038154	XenbaseID:	XB-GENE-478236	Length:	661	Species:	Xenopus tropicalis

Alignment Length:	632	Identity:	312/632 - (49%)
Similarity:	403/632 - (63%)	Gaps:	19/632 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PEIIRKPQNQ-GVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGTQSRYTVLE-QPGGISILRIE 98
            |:.|:.|.:: ||. ||||||.|.|.|||.|.:.|.|.||||:  ..|:..:| ..|..::|||:
Frog    24 PKFIKIPTDEIGVS-GGVASFVCQATGDPKPRVTWNKRGKKVN--SQRFETIEFDEGAGAVLRIQ 85

  Fly    99 PVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKA 163
            |:|..||:..|||||:|..|:.| ..|.||:...|:.|:|||.|..||..:|:|...|..|.|.|
Frog    86 PLRTPRDENVYECVAQNVHGEEV-VSAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAA 149

  Fly   164 IGNPTPNIYWIKNQTKVD--MSNPRY-SLKDGFLQIENSREEDQGKYECVAENSMGTEHSKATNL 225
            .|||.|.|.|.|:...||  .||.|. .|:.|.||||||.|.|||||||||.||.|..:|...||
Frog   150 SGNPDPEITWFKDFLPVDPASSNGRIKQLRSGALQIENSEETDQGKYECVATNSAGVRYSSPANL 214

  Fly   226 YVKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQL 290
            ||:||||.|.||..|.: .|:|.|.|:|::|:|||||||:||||.|:||||||::||:|||||:|
Frog   215 YVRVRRVAPRFSILPVS-HEIMPGGNVNITCVAVGSPMPYVKWMVGAEDLTPEDDMPVGRNVLEL 278

  Fly   291 INIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVI 355
            .|::|||||||:|.|:||.|:||:.:.|:|||.||....::|.||||:.:.|....|:.:.||||
Frog   279 TNVKESANYTCVAMSSLGVIESVAQITVKSLPKAPGTPVVTETTATSITVTWDSGNPDPVSYYVI 343

  Fly   356 QYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTK 420
            :||.|:.:..:.....|.|..|.:..|||.:|||.:|.|||:||:||||.|....||:     ..
Frog   344 EYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSEPVVTRTGE-----QA 403

  Fly   421 MESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSE 485
            ..|||||||.|.|||:||:|.||.|..||||:.||:||||...:||.:||....||:|.|||:..
Frog   404 PASAPRNVQARMLSSTTMIIQWEEPVEPNGQIRGYRVYYTMEPDQPVSSWLKYNVDDSLLTTIGS 468

  Fly   486 LTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENI 550
            |..|..|||||.|:||:|.||:|.|:|||.|||||.||.||||....||::.|.|:.|...|  |
Frog   469 LLEHETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNFRAEAKSETSIGLTWSPPRQDS--I 531

  Fly   551 VHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQY-- 613
            |.|||.:.:........|....:.:||::||.|:|.|...|||||..|.||.|..|..||.|.
Frog   532 VKYELNYREGEGGNEIRKTFDPATSYTVEGLKPNTEYLFRLAARSSHGLGAWTLDIKERTMQSKP 596

  Fly   614 GAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGRED 660
            .|||||:..:::.||||.:||||||.|..||.:..|.|.:..:..:|
Frog   597 SAPPRNVKCVSSKSTTILVSWLPPPAESQNGVLAGYSVRYSALDSDD 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	43/94 (46%)
		I-set	36..129	CDD:254352	43/94 (46%)
		IG_like	146..227	CDD:214653	43/83 (52%)
		Ig	159..228	CDD:299845	40/71 (56%)
		I-set	234..318	CDD:254352	51/83 (61%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	45/67 (67%)
		fn3	324..404	CDD:278470	33/79 (42%)
		FN3	423..514	CDD:238020	53/90 (59%)
		FN3	520..610	CDD:238020	36/89 (40%)
		FN3	616..707	CDD:238020	20/45 (44%)
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470
		PTPc	1476..1731	CDD:214550
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
ptprs	NP_001135464.1	I-set	24..115	CDD:369462	43/94 (46%)
		Ig2_RPTP_IIa_LAR_like	143..217	CDD:319301	40/73 (55%)
		Ig3_RPTP_IIa_LAR_like	237..305	CDD:143216	45/67 (67%)
		FN3	310..399	CDD:238020	37/88 (42%)
		FN3	406..498	CDD:238020	54/91 (59%)
		FN3	503..591	CDD:238020	36/89 (40%)
		fn3	599..>661	CDD:365830	20/45 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	418	1.000	Domainoid score	I643
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1246	1.000	Inparanoid score	I177
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	1	1.000	-	-		otm48333
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050