DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and ptpn23a

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_005158252.1	Gene:	ptpn23a / 100007322	ZFINID:	ZDB-GENE-100921-24	Length:	2003	Species:	Danio rerio

Alignment Length:	1667	Identity:	330/1667 - (19%)
Similarity:	525/1667 - (31%)	Gaps:	560/1667 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   705 LRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFD 769
            |.|...|.|.|. |||.|:|.|...|:......|    ::......|..|..|.|..|..    |
Zfish   327 LETLTSVKGAPL-VKALPVNPTDPSVTGPDIFAK----LVPMAAHEASSLYSEEKAKLLR----D 382

  Fly   770 VV-------DTLE--FNVTGLQPDTKYSIQV------------AALTRKGDGDRSAAIVVKTPGG 813
            |:       :|||  .:..||.|::..::::            |||:.:.|..::....::...|
Zfish   383 VMAKVDNKNETLEQFMDSLGLDPESVDNMEMYNTLPTVLMEKCAALSVRPDTVKNLIQSMQVLSG 447

  Fly   814 VPVRPTVSLK----IMEREPIVSIELEW--------ERPAQTYGELR------------------ 848
            |......||:    :::.:......||.        |||: |..|||
Zfish   448 VFTDVEASLREIRDVLDEDETEEQSLEEAVGKQAVPERPS-TLAELRRDLEKYLEAHEKASFTNT 511

  Fly   849 -----------GYRLRWGVKDQALKEEMLSGPQMTKKRFDNLER-----GVEYEFRVAGSNHIGI 897
                       ..||..|..|..  .|.|..||:::.....|:.     |...|.|...|:   :
Zfish   512 ELHRAMNLHISNLRLLGGPLDTL--REALPRPQLSEDEMAGLQTMKRILGKVQEMRDQRSS---L 571

  Fly   898 GQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGS 962
            .::...:.|..:.|               ..|..|.....::.....:.:|: |....||..|.:
Zfish   572 EKQLRDLIQQDDIT---------------TALVTTERADMKKLFEEQLKKYE-QVKVYIDQNLAA 620

  Fly   963 ERNM------------TLRKAVFTNLEE--NTEYIFRVRAY---------TKQGAGPFSD----- 999
            :.|:            |:||.: |..|.  |:.....|.:|         :::|...:.|
Zfish   621 QENILKALTEANVQYATVRKGL-TETEHKWNSTVQMLVASYEAYEDLMKKSQEGKEFYEDLETKA 684

  Fly  1000 -------KLIVETERDMGRA--PMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLD 1055
                   |.:.:..::..:|  ...|:.:|....||.   :|..::|:.:|..|         .|
Zfish   685 SRLLEKSKTVCKARKEERQAITERELKKKAPQRPTAP---KPAQNKGQNMGPSI---------SD 737

  Fly  1056 DWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVS--- 1117
            |                 .:.|:.:.||.|..    |.|.|:  :|..|.::.:...||.||
Zfish   738 D-----------------PELAELSAAILALG----GDLPEE--LRSLPPELTIPSSAHPVSGAA 779

  Fly  1118 -----------------THSMTLSWSPPIRLT--------PVNYKISFDAMKVFVDSQGFSQ--- 1154
                             .|....:..||..|.        |::...|....:..:..|.|.|
Zfish   780 PGSVLRWPGANSTLHYGQHRFPQNLPPPEVLAQISRFPTPPLSQSFSPSVPQPSLMQQQFPQMPN 844

  Fly  1155 TQIVPKREIILKH---------------YVKTHTINEL-SPFTTYN-VNVSAI-PSDYSYRPPTK 1201
            .|::|...:...|               ...|.|::.: :|.|:|: .:..|: ||...::.|..
Zfish   845 PQVLPPPPVSGYHPQPSQNQPGPSVTAVRPSTTTVDSIQTPITSYSPASAQAVMPSPGQHQVPHP 909

  Fly  1202 IT----VTTQMA---------------------APQPMVKPDFYGVVNGEEILVILPQASEEYGP 1241
            |:    ...|||                     ||.|..:|..:....|:.            .|
Zfish   910 ISSVYATPPQMAPHVQYMQQPGVPMSQPPQAMPAPHPQPQPQVFAQQGGQN------------QP 962

  Fly  1242 ISHYYLVVVPEDKSNLHKI----PDQFLTDDLLPGRNKPERPN--APYIAAKF---PQRSIPFTF 1297
            ...|...|:|..:.....:    |.|..|........:|..||  .|.:..:|   |..:.|
Zfish   963 QPFYPQAVLPSQQQMPRPLTGSQPSQHTTPQFPQYIRQPGPPNFQQPQMQGQFRAPPSHAPP--- 1024

  Fly  1298 HLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSP-------FSEFLSLDMREAPPGE 1355
            |.|...                   |..|...|...:.|.:|       .|..:.|.....||..
Zfish  1025 HQGYPP-------------------VSFVPKAPLPQVNTINPGQMSHSGVSPQMPLSSHPVPPVS 1070

  Fly  1356 RPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIV-LCVVKRRRQPCKTPDQAA 1419
            .||....|....|......:...|.:..|.|.:..|:..||:|.:. |..|.::..|...|....
Zfish  1071 MPHLAHVNQHIPPSSQPVPSMSMPHLARVNLQIAPSSQPVSSASMPHLAHVSQQIPPASQPQPPP 1135

  Fly  1420 VTR-----------------PLMAADLGAGPTPSDPVDMRRLNFQTPGM---------ISHPP-- 1456
            |..                 |.....:.|.||...|....:::..:..|         :|.||
Zfish  1136 VNHLSHPPHRQIHPSSHHLGPTPHMQIPAAPTQMPPPQQPQMHASSTHMSPPHPQMPSVSQPPPH 1200

  Fly  1457 --------------------------IPISEFANH------IERLKSNDNQKFSQEYESIEPGQQ 1489
                                      :||...|.|      ::...:..:|..:..:..|.|..
Zfish  1201 CPQSHIIPAHQPNQQPPYPAVPMQATVPIQPQAPHGSLPSQVQIHPNTPSQHQNHPHPQIIPQS- 1264

  Fly  1490 FTWDNSNLEHNKSKNR------------YANVTAYDHSRV------------------QLP---- 1520
               ....|.||..|.:            ...|....|..|                  |||
Zfish  1265 ---CPPALPHNMYKPQPTITPISAPMSFPGGVPMVPHQSVPSLQPQSQPPSSKPLVPQQLPPGGP 1326

  Fly  1521 ---AVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTR 1582
               ||..|       .|...|..:|....|:.||  ::.:.
Zfish  1327 ISYAVPQV-------GNIPPGAMQHPVATASPGP--QSMIP------------------------ 1358

  Fly  1583 IKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVP-- 1645
                   |:.|.....|..|..:.....:                            |..|.|
Zfish  1359 -------PSSGAPGAPQPHVLPSPAPSPS----------------------------PSPGPPSL 1388

  Fly  1646 ----DHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYG--- 1703
                ..|:|         ||||.....:......|...||.....||.|.:.::....|:..
Zfish  1389 GMTTQRPSP---------ALTPVGGAAMPQSSVQGPAPTGTMPQPDSTLFQRQNSSTDDLLSSSP 1444

  Fly  1704 --------HVTCL---------------RAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPAR-- 1743
                    ...|:               :|:...::| .|.|                :.|.|
Zfish  1445 ESQHGGTKDTACVLLPTKADPQEEHHRKKAEGVRLIQ-GDPY----------------QAPERVS 1492

  Fly  1744 NLHTHLQKLLIT------EPGE-TISGMEVEFKKL-SNVKMDSSKFVTANLPCNKHKNRLVHILP 1800
            .|...|::...|      ..|| .:|.::.::|:| ...:.|:.:...|...|...|||...::|
Zfish  1493 KLSAQLERFRSTVQSLERPTGEGGLSELDAQWKELQEQQEKDTRQLSIAIARCYTMKNRHQDVMP 1557

  Fly  1801 YESSRVYLTPIHGIEGSDYVNASFIDGYR-YRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLT 1864
            |:.:||.|   |..: .||:||||.:... |....||.|.|:...|.|||.|::|...:::|||.
Zfish  1558 YDCNRVVL---HSGK-DDYINASFTEDLSPYCPRLIATQAPLTGTAADFWLMVYEQKVSVIVMLV 1618

  Fly  1865 KLKEMGREKCFQYWPHERSVRYQYYVVDPI-----AEYNMPQYKLREFKVTDARDGSSRTVRQFQ 1924
            ..:|:.::|..:|:|.||.   |.....||     .:.:.|.:..|...:........|||...|
Zfish  1619 SEQELEKQKVLRYFPSERG---QQLAQGPITLTLTTQKSTPTHIERMIGLQYRDQSLRRTVVHLQ 1680

  Fly  1925 FIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ-------DGPITVHCSAGVGRSGVFITLSIVLE 1982
            |..|||.|:|:|....|.||.:||      |.       ..|:.||||:||||:|.|..|...|:
Zfish  1681 FTSWPELGLPESKSNLIRFIQEVH------GHYLLQRPLHTPVVVHCSSGVGRTGAFCLLYAALQ 1739

  Fly  1983 RMQY-EGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY 2023
            .::. .|:.|:.|.||.:|.||..|:|.:....|||.|.|::
Zfish  1740 EIEAGNGIPDLIQLVRKMRQQRKNMLQEKLHLKFCYEAVLKH 1781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020	1/1 (100%)
		FN3	712..810	CDD:238020	27/118 (23%)
		FN3	832..907	CDD:238020	22/116 (19%)
		FN3	914..1005	CDD:238020	19/125 (15%)
		FN3	1012..1101	CDD:238020	18/90 (20%)
		fn3	1106..1198	CDD:278470	24/140 (17%)
		PTPc	1476..1731	CDD:214550	46/323 (14%)
		PTPc	1503..1731	CDD:238006	41/296 (14%)
		PTPc	1763..2022	CDD:214550	89/273 (33%)
		PTPc	1791..2022	CDD:238006	84/244 (34%)
ptpn23a	XP_005158252.1	BRO1_HD-PTP_like	2..357	CDD:185762	12/30 (40%)
		V_HD-PTP_like	362..698	CDD:185747	64/362 (18%)
		ALIX_LYPXL_bnd	416..701	CDD:290660	51/307 (17%)
		Y_phosphatase	1548..1780	CDD:278528	84/244 (34%)
		PTPc	1549..1779	CDD:238006	84/242 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910