DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10366 and zfat

DIOPT Version :9

Sequence 1:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	XP_012820307.2	Gene:	zfat / 734084	XenbaseID:	XB-GENE-981323	Length:	1212	Species:	Xenopus tropicalis

Alignment Length:	756	Identity:	155/756 - (20%)
Similarity:	238/756 - (31%)	Gaps:	267/756 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 HVDRNPSSDWRQWCRLCAKDDVQGNLNVFLKNEDSGEAASMELATAIGKYFWVNITRGEELPETI 80
            |.|..|.:     |.||.                .|......|...|.|:.:|          .:
Frog   420 HGDERPFA-----CELCG----------------HGATKYQSLELHIRKHPFV----------YV 453

  Fly    81 CSECLSLVTSLVNFSERITR--------------VQKLYCILQSTPSQERPNLHELRSKFGLLDE 131
            ||.|.....|.|.....|..              :.:.:|:|:  |..:             :..
Frog   454 CSFCCKKFVSTVRLKAHIKERHSDAQEALVYNDSINQSFCLLE--PGSD-------------IQP 503

  Fly   132 ETQTEVHYVDKKPKLDEQLEFLPEESPYELANPL-------TPEEKQESVDQEQDQPTE------ 183
            |...::....|...|:..|..:||.......|.:       |.|.:|||:...|....|
Frog   504 EALRDIENPAKPLTLNGDLSLVPELHSTGQENTIQTDALGTTSEGQQESMGAFQVAEKEPGTCLP 568

  Fly   184 -----------------------------------EPDEQDADYEPNE------------DRVLM 201
                                               |.:...:::||.|            |.:|.
Frog   569 ILENGVDPKAGPLSTLGSVENEISCKGFVPLSSENENNHFSSEHEPVEGLHSAPATNQAADNILG 633

  Fly   202 SLCDVYGIQE-----DNSSAGSLDGSSPSTEKA-------------GEDAA-------------- 234
            |.....|.:.     :.|:..:..|.:|:||.:             ||.||
Frog   634 SAVLEEGARNVSSRTEQSTEVAEGGPNPTTEPSSHLLASNPPPSSPGETAAFMAILNGLHKRQLS 698

  Fly   235 ------------------------------------DSEKRHQCNECLRSYATSKTLQRHLRQDH 263
                                                ..|..:.|::|..|..|...|:||:.|.|
Frog   699 TALMQKIRKIYGELECEYCGKLFWYQVHYDMHVRTHTREHLYYCSQCSYSSITKNCLKRHVIQKH 763

  Fly   264 GQTEPTTEQLQCPD--C----PKKFRLHYQLERHMKWHVPLPKRKQYACSSCDKKFATSASAQQH 322
                 ::..|:||.  |    |.|    |:|:.|:|.|..|.| |.|:|.||:|.|:.....:.|
Frog   764 -----SSLLLKCPSEGCNYSSPDK----YKLQTHIKIHTDLEK-KTYSCPSCEKSFSDDRLIKSH 818

  Fly   323 EQYMHLDERPRPVICEQCG--------VGVHSM-------------SALKEHVLKHTDYAPFECE 366
            .:..| .|.|..:|.|..|        :|..::             |.|:.|:..|....||:|.
Frog   819 IKTNH-PEVPSSLISEVLGRKVQMKGLIGKRAVKCPFCDSYFMKNGSDLQRHIWAHEGLKPFKCS 882

  Fly   367 VCKKCFKSANRLKHHKETHDPHK-YICPECGMQLNSRTTLNRHRLVHT-DQMQHKCDYCGREFKR 429
            :|....:|.:.||.|...|...| ::|..||.:..|:.||..|:|:|| |..|.||..|.....:
Frog   883 MCDYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHTSDGKQFKCTVCEFTAVQ 947

  Fly   430 AKALKNHLILHTGLKPYSCDFCDRTFANGSNCRTHKKKSHPEELA--------AQEAA---GGGR 483
            .:.|..|:..||..||:.|..|..:.....:.:.|..|.||::..        :|||.   ||.:
Frog   948 KRHLVRHMEQHTSFKPFGCALCHYSCNIPGSLKRHYNKKHPDKQCVNAGTGEISQEAVLLQGGMK 1012

  Fly   484 ------------SHNRNIPKLEALKAFTKNKD-NLSPVATKQSGCFAFGKKPRPATKDTPASNPA 535
                        ..||::.....||......| ....:.|.:..|..:.......| |...:..|
Frog  1013 CPVCSFVYGTKWEFNRHLKNKHGLKLVENEGDAKWESLDTTEETCTQYLHIADTET-DVQGTEAA 1076

  Fly   536 V--IQDAQPEPAPDPGGENATQADTPAAAIPTLDNIYNHIM 574
            |  :||.:            ..:||.....||..||...|:
Frog  1077 VAALQDLR------------YTSDTSDKLDPTAVNILQQII 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071	15/93 (16%)
		PTZ00423	131..>230	CDD:240413	27/176 (15%)
		COG5048	<222..408	CDD:227381	65/276 (24%)
		C2H2 Zn finger	242..263	CDD:275368	8/20 (40%)
		C2H2 Zn finger	275..295	CDD:275368	9/25 (36%)
		C2H2 Zn finger	306..357	CDD:275368	16/71 (23%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	8/19 (42%)
		zf-C2H2	418..440	CDD:278523	5/21 (24%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
		zf-H2C2_2	432..457	CDD:290200	8/24 (33%)
		C2H2 Zn finger	448..466	CDD:275368	3/17 (18%)
zfat	XP_012820307.2	zf-C2H2	265..287	CDD:395048
		C2H2 Zn finger	267..287	CDD:275368
		zf-H2C2_5	293..317	CDD:404746
		C2H2 Zn finger	295..315	CDD:275368
		C2H2 Zn finger	322..343	CDD:275368
		C2H2 Zn finger	350..371	CDD:275368
		C2H2 Zn finger	400..420	CDD:275368	155/756 (21%)
		C2H2 Zn finger	428..448	CDD:275368	6/35 (17%)
		C2H2 Zn finger	454..472	CDD:275368	5/17 (29%)
		C2H2 Zn finger	714..734	CDD:275368	0/19 (0%)
		zf-H2C2_5	740..764	CDD:404746	9/28 (32%)
		C2H2 Zn finger	742..792	CDD:275368	19/58 (33%)
		COG5048	<761..926	CDD:227381	50/175 (29%)
		C2H2 Zn finger	802..821	CDD:275368	6/18 (33%)
		C2H2 Zn finger	852..873	CDD:275368	3/20 (15%)
		C2H2 Zn finger	881..901	CDD:275368	6/19 (32%)
		C2H2 Zn finger	909..929	CDD:275368	8/19 (42%)
		zf-H2C2_5	936..959	CDD:404746	5/22 (23%)
		C2H2 Zn finger	938..958	CDD:275368	4/19 (21%)
		C2H2 Zn finger	966..987	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1013..1031	CDD:275368	2/17 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100