DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10366 and ZNF462

DIOPT Version :9

Sequence 1:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	XP_006717272.1	Gene:	ZNF462 / 58499	HGNCID:	21684	Length:	2567	Species:	Homo sapiens

Alignment Length:	665	Identity:	124/665 - (18%)
Similarity:	206/665 - (30%)	Gaps:	246/665 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 CRLCAKDDVQGNLNVFLKNEDSGEAASMELATAIGKYFWVNITRGEELPETICSECLSLVTSLVN 93
            |.|||          :......|.||..:....|..|:               :.||:...::
Human  1699 CALCA----------YTNPIRKGLAAHYQKRHDIDAYY---------------THCLAASRTI-- 1736

  Fly    94 FSERITRVQKLYCILQSTPSQERPNL-HELR----------------SKFGLLDEETQTEVHYVD 141
             |::..:|     |:.|.|..:.|.| .|||                ||.|::.       ||:.
Human  1737 -SDKPNKV-----IIPSPPKDDSPQLSEELRRAVEKKKCSLCSFQSFSKKGIVS-------HYMK 1788

  Fly   142 KKPKLDEQLEFLPEESPYELANPLTPEEKQESVDQEQDQPTEEPDEQDADYEPNEDRVLMSLCDV 206
            :.|.:     |..::...:|....|     .....|.::||...:|:..::|..|
Human  1789 RHPGV-----FPKKQHASKLGGYFT-----AVYADEHEKPTLMEEEERGNFEKAE---------- 1833

  Fly   207 YGIQEDNSSAGSLDGSSPSTEKAGEDAADSEKRHQCNECLR-SYATSKTLQRHLRQDHGQ----- 265
                        ::|.:...|..         ..:|.:|.: |::|::.|..|....|.:
Human  1834 ------------VEGEAQEIEWL---------PFRCIKCFKLSFSTAELLCMHYTDHHSRDLKRD 1877

  Fly   266 -----TEPTTEQ--LQCPDCPKKFRLHYQLERHMKWH-------VPLPKRKQYACSSCDKKFATS 316
                 ..|..:.  .||..|..|.:...:|..|:..|       ....:|::...|.  :|:|..
Human  1878 FIILGNGPRLQNSTYQCKHCDSKLQSTAELTSHLNIHNEEFQKRAKRQERRKQLLSK--QKYADG 1940

  Fly   317 ASA--QQHEQYMHLDERP----RPVI---CEQCGVGVH-SMSALKEHVLKHTDY----------- 360
            |.|  :|...:.||:|.|    |.|:   |:.| |.|| ::.|:..|:.||..|
Human  1941 AFADFKQERPFGHLEEVPKIKERKVVGYKCKFC-VEVHPTLRAICNHLRKHVQYGNVPAVSAAVK 2004

  Fly   361 ---------------------------------------------APFECEVCKKCFKSANRLKH 380
                                                         ..:.|..|.:...|...|:.
Human  2005 QEADDPAHLFLDGLEAAKDASGALVGRVDGEHCLLDGMLEDETRPGGYHCSQCDRVLMSMQGLRS 2069

  Fly   381 HKETH-------DPHKYICPECGMQLNSRTTLNRHRLVHTDQMQHK---CDYCGREFKRAKALKN 435
            |:.:|       ...||.|..|......|..|:||  :.|....||   |..|..:......||.
Human  2070 HERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRH--MQTHHGHHKPFRCKLCSFKSSYNSRLKT 2132

  Fly   436 HLI-LHTGLKPYSCDFCDRTFANGSNCRTHKKKSHPEELAAQEAAGGGRSHNRNIPKLEALKAFT 499
            |:: .|.|...|.|.:|..:....|..:.|..|.|.:.|              .:|:...:...:
Human  2133 HILKAHAGEHAYKCSWCSFSTMTISQLKEHSLKVHGKAL--------------TLPRPRIVSLLS 2183

  Fly   500 KNKDNLSPVATKQSGCFAFGKKPRPA-----TKDTPASNPAVIQ--------------DAQPEPA 545
            .:..:.|..||             ||     :.|:..|.|..:|              :::..|.
Human  2184 SHSHHSSQKAT-------------PAEEVEDSNDSSYSEPPDVQQQLNHYQSAALARNNSRVSPV 2235

  Fly   546 PDPGGENATQADTPA 560
            |..|....|:..|.|
Human  2236 PLSGAAAGTEQKTEA 2250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071	13/78 (17%)
		PTZ00423	131..>230	CDD:240413	14/98 (14%)
		COG5048	<222..408	CDD:227381	51/278 (18%)
		C2H2 Zn finger	242..263	CDD:275368	6/21 (29%)
		C2H2 Zn finger	275..295	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..357	CDD:275368	19/60 (32%)
		C2H2 Zn finger	365..385	CDD:275368	5/19 (26%)
		C2H2 Zn finger	392..412	CDD:275368	6/19 (32%)
		zf-C2H2	418..440	CDD:278523	7/25 (28%)
		C2H2 Zn finger	420..440	CDD:275368	5/20 (25%)
		zf-H2C2_2	432..457	CDD:290200	8/25 (32%)
		C2H2 Zn finger	448..466	CDD:275368	4/17 (24%)
ZNF462	XP_006717272.1	C2H2 Zn finger	2054..2074	CDD:275368	5/19 (26%)
		C2H2 Zn finger	2088..2108	CDD:275368	6/21 (29%)
		C2H2 Zn finger	2117..2138	CDD:275368	5/20 (25%)
		zf-H2C2_5	2144..2169	CDD:316431	7/24 (29%)
		C2H2 Zn finger	2146..2167	CDD:275368	5/20 (25%)
		C2H2 Zn finger	2317..2337	CDD:275368
		C2H2 Zn finger	2363..2383	CDD:275368
		C2H2 Zn finger	2391..2412	CDD:275368
		C2H2 Zn finger	2477..2497	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100