DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10366 and LOC568955

DIOPT Version :9

Sequence 1:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	XP_697406.4	Gene:	LOC568955 / 568955	-ID:	-	Length:	541	Species:	Danio rerio

Alignment Length:	502	Identity:	104/502 - (20%)
Similarity:	160/502 - (31%)	Gaps:	171/502 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 FGLLDEETQT------EVHYVDKKPKLDEQLEFLPEE--SPY--------ELANPLTPEEKQESV 174
            :|..||:..:      |..:.|.:....|:.|..||.  :||        .|.:||:.....:
Zfish    68 YGFSDEDCSSYNRLGIESDFEDPRDTESEREEMAPEAAFAPYLSCRQCGQLLGDPLSGLYCLQ-- 130

  Fly   175 DQEQDQPTEEPDEQDADYEPNE--DRVLMSLCDVYGIQEDNSSAGSLDGSSPST----------- 226
                   ..|.|.||...||..  |..|           :|.:....||::..|
Zfish   131 -------CGETDRQDRSLEPTHPADNTL-----------ENLNHSRSDGNTSKTFSCKLCSFSSR 177

  Fly   227 ----EKAGEDAADSEKRHQCNECLRSYATSKTLQRHLRQDHGQTEPTTEQLQCPDCPKKFRLHYQ 287
                .|......:.||.:||..|:.:.|....||||:|...|:     :..:|..|.........
Zfish   178 YSNHLKRHMKTHNGEKPYQCPHCVYASAQLVNLQRHVRTHTGE-----KPYKCQFCTFACNSLGN 237

  Fly   288 LERHMKWHVPLPKRKQYACSSCDKKFATSASAQQH------------------------------ 322
            |:||.:.|.   :.|:.:|:.||.:.:.|.|.::|
Zfish   238 LKRHQRMHT---QEKELSCAHCDFRASNSHSLKKHTKSHKEDKTTALTEESVVSDLTLHISSDPD 299

  Fly   323 --EQYMH-------------------------------------------LD--ERPRPVICEQC 340
              :.|.|                                           ||  |...|.||.:|
Zfish   300 FLQNYDHHHNHHLPSHLPPPALLHNEGLSGESDPLPELLFPFSCRVCGAVLDDEEATAPQICSKC 364

  Fly   341 GVGVHSMSA----------------------LKEHVLKHTDYAPFECEVCKKCFKSANRLKHHKE 383
            .:.:.|.|:                      |..|:..|:...|::|..|.......:.||.|..
Zfish   365 TLDMLSKSSPDKDDKLFPCTSCPFVTQYPNHLARHMKTHSGEKPYKCPQCSYASAHFDNLKRHHR 429

  Fly   384 THDPHK-YICPECGMQLNSRTTLNRHRLVHTDQMQHKCDYCGREFKRAKALKNHLILHTGLKPYS 447
            .|...| |.|..|.....:...|.||..:|:.....:|..|.....::..||.|::.|||.||:.
Zfish   430 VHTGEKPYKCRVCDYACGNLANLKRHERIHSGSKPFQCSVCSYSCNQSMNLKRHMLRHTGEKPFK 494

  Fly   448 CDFCDRTFANGSNCRTHKKK-SHPEELAAQEAAGGGRSHNRNIPKLE 493
            |..|..|..:..|.:.|:|| .|         |||.......:|:.|
Zfish   495 CQHCGYTTGHWDNYKRHQKKHGH---------AGGEGWIKMQLPEKE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071
		PTZ00423	131..>230	CDD:240413	25/131 (19%)
		COG5048	<222..408	CDD:227381	53/300 (18%)
		C2H2 Zn finger	242..263	CDD:275368	8/20 (40%)
		C2H2 Zn finger	275..295	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..357	CDD:275368	19/149 (13%)
		C2H2 Zn finger	365..385	CDD:275368	5/19 (26%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		zf-C2H2	418..440	CDD:278523	5/21 (24%)
		C2H2 Zn finger	420..440	CDD:275368	5/19 (26%)
		zf-H2C2_2	432..457	CDD:290200	11/24 (46%)
		C2H2 Zn finger	448..466	CDD:275368	5/17 (29%)
LOC568955	XP_697406.4	C2H2 Zn finger	169..189	CDD:275368	1/19 (5%)
		zf-H2C2_2	181..206	CDD:290200	6/24 (25%)
		COG5048	193..>467	CDD:227381	53/281 (19%)
		C2H2 Zn finger	197..217	CDD:275368	8/19 (42%)
		zf-H2C2_2	209..234	CDD:290200	8/29 (28%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		C2H2 Zn finger	383..403	CDD:275368	2/19 (11%)
		zf-H2C2_2	395..420	CDD:290200	6/24 (25%)
		C2H2 Zn finger	411..431	CDD:275368	5/19 (26%)
		zf-H2C2_2	423..446	CDD:290200	8/22 (36%)
		C2H2 Zn finger	439..459	CDD:275368	5/19 (26%)
		zf-H2C2_2	451..476	CDD:290200	6/24 (25%)
		C2H2 Zn finger	467..487	CDD:275368	5/19 (26%)
		zf-H2C2_2	479..502	CDD:290200	10/22 (45%)
		C2H2 Zn finger	495..515	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100