DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10366 and ZNF407

DIOPT Version :9

Sequence 1:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_001371404.1	Gene:	ZNF407 / 55628	HGNCID:	19904	Length:	2248	Species:	Homo sapiens

Alignment Length:	606	Identity:	140/606 - (23%)
Similarity:	222/606 - (36%)	Gaps:	159/606 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LKNEDSGEAASME----LATAIGKYFWVNITRGEELP----------------------ETICSE 83
            :||.:.||.....    :||.:         |..|||                      ...|.:
Human  1363 IKNPEDGELIDQSEEGLIATGV---------RISELPLKDCAQGVKKKKSEGSSIGESTRIRCDD 1418

  Fly    84 CLSLVTSLVNFSERI-----TRVQKLYCILQSTPSQERPNLHELRSKFGLLDEETQTEVHYVDKK 143
            |..|...|...:..|     |:.:..:|:|.........|||:..:..|          |..:::
Human  1419 CGFLADGLSGLNVHIAMKHPTKEKHFHCLLCGKSFYTESNLHQHLASAG----------HMRNEQ 1473

  Fly   144 PKLDEQLEFLPEESP----YELANPLTPEE--------KQESVDQEQDQPTEEPDEQ-DADYEPN 195
            ..::|    |||...    .:...|...|:        :.|.:.:|.::...|..|| :.:.|.|
Human  1474 ASVEE----LPEGGATFKCVKCTEPFDSEQNLFLHIKGQHEELLREVNKYIVEDTEQINREREEN 1534

  Fly   196 EDRVLMSLCDVYG--IQEDNSSA-----GSLDGSSP--------STEKAGEDAADSEKRH----- 240
            :..|    |...|  .:..||.|     .:..||.|        :|.:.| ||.:..|||
Human  1535 QGNV----CKYCGKMCRSSNSMAFLAHIRTHTGSKPFKCKICHFATAQLG-DARNHVKRHLGMRE 1594

  Fly   241 -QCNECLRSYATSKTLQRHLRQDHGQTEPTTEQLQCPDCPKKFRLHYQLERHMKWHVPLPKRKQY 304
             :|:.|..::...|.|..||...||...|...:..|..|.:.|...:.|..|||.|.   ..|.:
Human  1595 YKCHVCGVAFVMKKHLNTHLLGKHGVGTPKERKFTCHLCDRSFTEKWALNNHMKLHT---GEKPF 1656

  Fly   305 ACS--SCDKKFATSASAQQHEQYMHLDERPRPVICEQCGVGVHSMSALKEHVLKHTDYAPFECEV 367
            .|:  :|...|.|:::.:.|.: .|..|  :..:|:.||....:..||.:|..:||...||:|:
Human  1657 KCTWPTCHYSFLTASAMKDHYR-THTGE--KSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCD- 1717

  Fly   368 CKKCFKSANRLKHHKETHDPHKYICPECGMQLNSRTTLNRHRLVHTDQMQHKCDYCGREFKRAKA 432
                                      ||.....:::.|.||:.|||.:..::|.:|......|:.
Human  1718 --------------------------ECNFASTTQSHLTRHKRVHTGEKPYRCPWCDYRSNCAEN 1756

  Fly   433 LKNHLILHT----GLKPYSCDFCDRTFANGSNC----RTHKKKSHPE----ELAAQEAAGGGRSH 485
            ::.| ||||    |:|.|:|..||    .|:|.    |.|.|:.||:    :||...|....:|:
Human  1757 IRKH-ILHTGKHEGVKMYNCPKCD----YGTNVPVEFRNHLKEQHPDIENPDLAYLHAGIVSKSY 1816

  Fly   486 NRNIPKLEALKAFTKNKDNLSPVATKQSGCFAFGKKP-----RPATKDTPASNPAVIQDAQPEPA 545
            ...:....|  .|.:.....:..|..:.....  :||     |||..........:.|....|.|
Human  1817 ECRLKGQGA--TFVETDSPFTAAALAEEPLVK--EKPLRSSRRPAPPPEQVQQVIIFQGYDGEFA 1877

  Fly   546 PDPGGENATQADTPAAAIPTL 566
            .||..|     :|.||.:.||
Human  1878 LDPSVE-----ETAAATLQTL 1893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071	17/93 (18%)
		PTZ00423	131..>230	CDD:240413	24/126 (19%)
		COG5048	<222..408	CDD:227381	48/201 (24%)
		C2H2 Zn finger	242..263	CDD:275368	6/20 (30%)
		C2H2 Zn finger	275..295	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..357	CDD:275368	13/52 (25%)
		C2H2 Zn finger	365..385	CDD:275368	1/19 (5%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		zf-C2H2	418..440	CDD:278523	5/21 (24%)
		C2H2 Zn finger	420..440	CDD:275368	5/19 (26%)
		zf-H2C2_2	432..457	CDD:290200	11/28 (39%)
		C2H2 Zn finger	448..466	CDD:275368	7/21 (33%)
ZNF407	NP_001371404.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..84
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	217..238	CDD:275368
		C2H2 Zn finger	246..268	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..322
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..515
		C2H2 Zn finger	590..614	CDD:275371
		C2H2 Zn finger	617..639	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..700
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..847
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..962
		C2H2 Zn finger	1416..1445	CDD:275371	6/28 (21%)
		C2H2 Zn finger	1446..1468	CDD:275371	6/31 (19%)
		C2H2 Zn finger	1488..1509	CDD:275371	2/20 (10%)
		C2H2 Zn finger	1539..1561	CDD:275368	5/21 (24%)
		zf-H2C2_2	1557..1578	CDD:404364	4/20 (20%)
		C2H2 Zn finger	1569..1589	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1597..1617	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1630..1650	CDD:275368	7/19 (37%)
		zf-H2C2_2	1642..1669	CDD:404364	9/29 (31%)
		C2H2 Zn finger	1658..1680	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1688..1708	CDD:275368	6/19 (32%)
		zf-H2C2_2	1700..1725	CDD:404364	10/51 (20%)
		zf-H2C2_5	1714..1738	CDD:404746	9/50 (18%)
		C2H2 Zn finger	1716..1736	CDD:275368	6/46 (13%)
		zf-H2C2_2	1728..1753	CDD:404364	8/24 (33%)
		C2H2 Zn finger	1744..1761	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100