DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10366 and znf131

DIOPT Version :9

Sequence 1:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_956799.2	Gene:	znf131 / 393477	ZFINID:	ZDB-GENE-040426-1563	Length:	558	Species:	Danio rerio

Alignment Length:	340	Identity:	89/340 - (26%)
Similarity:	136/340 - (40%)	Gaps:	50/340 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 KKPKLDEQLEFLPEESPYELANPLTPEEKQESVDQEQDQPTEEPDEQDADYEPNEDRVLMSLCDV 206
            ||.|:.|....:.|..|              |.|.|..:...|..|:..:.   |:..|:.:.||
Zfish   139 KKRKISETSNVITESLP--------------SADTEAVEIEVEVGEEHIEV---EESGLVEVVDV 186

  Fly   207 ---YGIQEDNSSAGSLDGSSPSTEKAGEDAADSEKRHQCNECLRSYA--TSKTLQRHLRQDHGQT 266
               ..:...:.||.:|.....|..:.||......|:......::..|  .||||: ::.....|.
Zfish   187 ARGTTVPSSDDSALALLADITSKYQQGEQTLHVIKKVDETVVVQEEAVVASKTLE-NIEVVEVQI 250

  Fly   267 EPTTEQLQCPDCPKKFRLHYQLERHMKWHVPLPKRKQYACSSCDKKFATSASAQQHEQYMHLD-- 329
            .......:|..|.:.|:|:|.|::|||.|:..|:| .:.|..|.|.:|...:.:||....|.|
Zfish   251 SQLDNLFRCDKCDRCFKLYYHLKQHMKTHIASPER-GFVCRHCGKAYAREGALKQHLNNYHFDAE 314

  Fly   330 -----ERPRPVICEQCGVGVHSMSALKEHVLKHTDYAPFECEVCKKCFKSANRLKHHKETHDPHK 389
                 ::.:..:||.|..........|||:.|||...||||..|.:.|...:.||.|...
Zfish   315 EQSRRQKKKVHVCEYCEKQFDHFGHFKEHLRKHTGEKPFECPECHERFARNSTLKCHMSA----- 374

  Fly   390 YICPECGMQLNSRTTLNRHRLVHTDQMQHKCDYCGREFKRAKALKNHLILHTGLKPYSCDFCDRT 454
                 |  |..|.....|.:|       ::|..|...|...:..|:||:.|||.||..|..||..
Zfish   375 -----C--QNGSGAKKGRKKL-------YECQVCSSVFNSWEQFKDHLVTHTGEKPNHCTLCDLW 425

  Fly   455 FANGSNCRTHKKKSH 469
            |.:..:..||.::.|
Zfish   426 FTSPRDLHTHLQEHH 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071
		PTZ00423	131..>230	CDD:240413	19/90 (21%)
		COG5048	<222..408	CDD:227381	51/194 (26%)
		C2H2 Zn finger	242..263	CDD:275368	5/22 (23%)
		C2H2 Zn finger	275..295	CDD:275368	9/19 (47%)
		C2H2 Zn finger	306..357	CDD:275368	14/57 (25%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		zf-C2H2	418..440	CDD:278523	6/21 (29%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..457	CDD:290200	12/24 (50%)
		C2H2 Zn finger	448..466	CDD:275368	6/17 (35%)
znf131	NP_956799.2	BTB	24..120	CDD:306997
		zf-C2H2	257..279	CDD:306579	9/21 (43%)
		C2H2 Zn finger	259..279	CDD:275368	9/19 (47%)
		C2H2 Zn finger	289..347	CDD:275368	14/57 (25%)
		COG5048	<310..441	CDD:227381	43/150 (29%)
		C2H2 Zn finger	327..344	CDD:275368	5/16 (31%)
		zf-H2C2_2	339..364	CDD:316026	12/24 (50%)
		C2H2 Zn finger	355..372	CDD:275368	5/16 (31%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100