DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10366 and CG4707

DIOPT Version :9

Sequence 1:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_611944.1	Gene:	CG4707 / 37935	FlyBaseID:	FBgn0035036	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	657	Identity:	143/657 - (21%)
Similarity:	237/657 - (36%)	Gaps:	235/657 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 CRLCAKDDVQGNLNVFLKNEDSGEAASMELATAIGKYFWVN--ITRGEELPETICSECLSLVTSL 91
            |.||..   ..|....|::|   |...:.:...|.|:|..:  :|.|.:  ..:|.||.:.|:|.
  Fly     4 CVLCLD---SSNAGYGLQSE---EGVRLNIRATIHKHFAFSEVLTAGGD--AEVCRECWNCVSSF 60

  Fly    92 VNFSERITRVQK------------------------LYCI-LQS------TPSQERPNLHELR-- 123
            ..|.:|::.:.:                        ||.: |.:      .||:.:..::||.
  Fly    61 EEFHQRVSCLHRQRSSDSKSEPIEFCGQTEEAIINPLYSVELDALAEAFFAPSEVKVEVNELEPL 125

  Fly   124 SKFGLLDEETQTEVHYVDK------------KPKLDEQLEFLPEESPYELANPLTPEEKQESVDQ 176
            .|..||::..:||:....|            |.::..:|. :..:|...||:.|..:.|:.||..
  Fly   126 PKVELLEDPVKTEIRTAPKRLGVPNEGSPHSKRRIKNELP-VDSDSDAPLADFLNSDSKRSSVGP 189

  Fly   177 EQDQ-----------------PTEEPD-----EQDADYEPNEDRVLMSLCDVYGIQEDNSS---- 215
            .::.                 |..:|:     :::.|.|..|:..           .||:.
  Fly   190 AKNSEANKGRQLRRSARRGRPPKAKPESAPSPKKELDSEDGEENA-----------RDNNDMEFV 243

  Fly   216 -----AGSLDGSSPSTEKAGEDAADS---------------------------EK---------- 238
                 .|:.|.||.|:|.:|||:..|                           ||
  Fly   244 APEAVLGTDDSSSSSSESSGEDSDHSLPDIEPEERYAEIPKRVVVKPKKYRKREKPLVPPVRLSR 308

  Fly   239 ----------------------------------------RHQ---------------------- 241
                                                    |||
  Fly   309 EEIERRKLQQDEYDEIILQFFKKFPCSLCNLLVQNFADMRRHQRVSHNIESGYIECCGRKFHLRK 373

  Fly   242 ----------------CNECLRSYATSKTLQRHLRQDHG----QTEPTTEQL-QCPDCPKKFRLH 285
                            |::|.|.:..|:.|:.| .|.|.    :.||..::: ||..|||.|...
  Fly   374 ALAEHVLVHKNPDHFMCSQCGRVFQDSRALEVH-EQTHTNPEVKAEPKEKRIYQCEKCPKSFTTK 437

  Fly   286 YQLERH-MKWHVPLPKRKQYACSSCDKKFATSASAQQHEQYMHLDERPRPVICEQCGVGVHSMSA 349
            ..:|.| :..|||..:.| |:|..|:||..|....::|.:|||..|  ..:||::||..:.|.:.
  Fly   438 AAMEYHDVSKHVPKSEFK-YSCPECNKKIPTERKLKEHLRYMHDPE--AAIICDKCGKTLRSQTN 499

  Fly   350 LKE-HVLKHTDYA-----PFECEVCKKCFKSANRLKHHKET-HDP--HKYICPECGMQLNSRTTL 405
            ||: |.|:|::..     |.:||:|....:..:.||.|.:| |:|  .::.|..|.....:...|
  Fly   500 LKKHHELEHSEKPRPKPDPVQCEICGTWLRHLSGLKQHMKTVHEPPGDEHRCHICNKTSTNSRAL 564

  Fly   406 NRHRLVHTD--QMQHKCDYCGREFKRAKALKNHLILHTGLKPYSCDFCDRTFANGSNCRTHKKKS 468
            .|| :.|..  :.:.||..|.:.|||.:.|:.|...|||...|:|..|..||.:.:|...|:::.
  Fly   565 KRH-IYHNHLCERKFKCGMCEKAFKRPQDLREHTSTHTGEVLYTCPNCPMTFFSNANMYKHRQRL 628

  Fly   469 HPEELAA 475
            |..|..|
  Fly   629 HRAEWEA 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071	21/105 (20%)
		PTZ00423	131..>230	CDD:240413	25/141 (18%)
		COG5048	<222..408	CDD:227381	69/315 (22%)
		C2H2 Zn finger	242..263	CDD:275368	7/20 (35%)
		C2H2 Zn finger	275..295	CDD:275368	7/20 (35%)
		C2H2 Zn finger	306..357	CDD:275368	19/51 (37%)
		C2H2 Zn finger	365..385	CDD:275368	7/20 (35%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		zf-C2H2	418..440	CDD:278523	8/21 (38%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..457	CDD:290200	10/24 (42%)
		C2H2 Zn finger	448..466	CDD:275368	6/17 (35%)
CG4707	NP_611944.1	zf-AD	3..73	CDD:285071	19/76 (25%)
		C2H2 Zn finger	334..355	CDD:275368	3/20 (15%)
		LIM	<361..407	CDD:295319	6/46 (13%)
		C2H2 Zn finger	365..382	CDD:275368	0/16 (0%)
		C2H2 Zn finger	390..410	CDD:275368	7/20 (35%)
		C2H2 Zn finger	427..443	CDD:275368	6/15 (40%)
		C2H2 Zn finger	458..476	CDD:275368	6/17 (35%)
		C2H2 Zn finger	487..507	CDD:275368	7/19 (37%)
		C2H2 Zn finger	521..540	CDD:275368	6/18 (33%)
		C2H2 Zn finger	551..572	CDD:275368	6/21 (29%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		C2H2 Zn finger	608..629	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940