DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10366 and CG4282

DIOPT Version :9

Sequence 1:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	697	Identity:	150/697 - (21%)
Similarity:	236/697 - (33%)	Gaps:	261/697 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VDRNPSSDWRQWCRLCAKD---------DVQGNLNVFLKNEDSGEAASMELATAIGKYFWVNITR 72
            :|.:||      |.||..:         ||.           |.....:|:.|.:.::|.|.|::
  Fly     1 MDSSPS------CLLCMCEYPAMMGDYIDVH-----------SARGDQLEVTTIVNQHFPVQISK 48

  Fly    73 GEELPETICSECLSLVTSLVNFSERITRVQK-----LYCILQSTP-SQERPNLHELRSKFGLLDE 131
              |..|.||..|..:|:......|.::..|.     ...:::..| :||..:..|: .|....:|
  Fly    49 --ESDERICGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEI-IKLATQEE 110

  Fly   132 ETQT-----------------EVHYVDKKPKLD------------EQLEFL-------------- 153
            |..|                 |.|.:|..|:::            :|||..
  Fly   111 EGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGS 175

  Fly   154 ------PEESPYELANPLTPEEK---------------QESVDQEQDQPTEEPDE-QDADYEPNE 196
                  .|:...|.|.|..|:::               :...|.:.|...||.|| .|.:.:|:.
  Fly   176 SVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDF 240

  Fly   197 DRVLMSLCDVYGIQEDNSSA--GSLDG---------------------------------SSPST 226
            ..::.|         ||||.  |..||                                 :.|:.
  Fly   241 SCLVPS---------DNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAE 296

  Fly   227 EKA--GEDAADSEKRHQ-------------------CNECLRSYATSKTLQRHLRQDHGQTEPTT 270
            .|.  ..:..:..|:.|                   ||..:.::.   .:|||.|..| |.:|
  Fly   297 PKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFT---EMQRHHRLTH-QVDP-- 355

  Fly   271 EQLQCPDCPKKFRLHYQLERHMKWHVPLPKRKQYACSSCDKKFATSASAQQHEQYMHLDERPRPV 335
            ..:.|  |.:||.....|..|:..|.   ....:.||.|:|.|..|...:.|:| :|:|    |.
  Fly   356 GYMMC--CGRKFTQRKVLAEHVLVHW---NPDHFKCSVCEKSFQNSRHLESHQQ-VHMD----PA 410

  Fly   336 I-----CEQCGVGVHSMSALKEHVL-KHTDYAPFE--CEVCKKCFKSANRLKHHKET-HDPHK-Y 390
            :     |:.|.....|.:|:..|.| ||...:.|:  |..|.|.|.:..:||:|..: |||.. .
  Fly   411 VKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTI 475

  Fly   391 ICPECGMQLNSRTTLNRHR-LVHTDQ-----------------------MQH------------- 418
            ||.:||.|:.::..|.:|: |:|:|:                       .||
  Fly   476 ICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHR 540

  Fly   419 ----------------------------KCDYCGREFKRAKALKNHLILHTGLKPYSCDFCDRTF 455
                                        ||..|.:.|||.:.||.|...|||...|:|..|..||
  Fly   541 CHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTF 605

  Fly   456 ANGSNCRTHKKKSHPEELAAQEAAGGGRSHNRNIPKLEALKAFTKNK 502
            ...:|...|:::.|    .||..|...:....||.|: :..|.|:||
  Fly   606 FCSANMYKHRQRLH----RAQYEADKNQPKPPNILKI-SRNASTQNK 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071	19/93 (20%)
		PTZ00423	131..>230	CDD:240413	33/200 (17%)
		COG5048	<222..408	CDD:227381	56/216 (26%)
		C2H2 Zn finger	242..263	CDD:275368	6/20 (30%)
		C2H2 Zn finger	275..295	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..357	CDD:275368	17/56 (30%)
		C2H2 Zn finger	365..385	CDD:275368	7/20 (35%)
		C2H2 Zn finger	392..412	CDD:275368	7/20 (35%)
		zf-C2H2	418..440	CDD:278523	10/62 (16%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..457	CDD:290200	11/24 (46%)
		C2H2 Zn finger	448..466	CDD:275368	6/17 (35%)
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	19/86 (22%)
		FYDLN_acid	<191..268	CDD:302856	18/85 (21%)
		C2H2 Zn finger	330..351	CDD:275368	6/23 (26%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	12/41 (29%)
		C2H2 Zn finger	386..406	CDD:275368	8/20 (40%)
		zf-C2H2_8	389..465	CDD:292531	24/80 (30%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	2/20 (10%)
		C2H2 Zn finger	541..562	CDD:275368	0/20 (0%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471727
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940