DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10366 and CG8388

DIOPT Version :9

Sequence 1:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	608	Identity:	140/608 - (23%)
Similarity:	228/608 - (37%)	Gaps:	144/608 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 CRLCAK--DDVQGNLNVFLKNEDSGEAASMELATAIGKYFWVNITRGEELPET-----ICSECLS 86
            |.||.:  ||..||:..     .|.||.|:.|...|.|:||:      ::|::     :|..|..
  Fly     3 CFLCTQTVDDAAGNIEF-----ASEEADSLGLRCIIEKHFWL------QIPDSKRAGYVCGPCWE 56

  Fly    87 LVTSLVNFSERITRVQKL--YCILQSTPSQE----------------------------RP---- 117
            .:....||...:.:..|.  ..:|:.|...|                            ||
  Fly    57 QLLLFHNFYLNVEQAHKALEQTVLKETSPPEVVASALEEHIVKSEHDDSVAAAVKRRRGRPRKVA 121

  Fly   118 ---------------NLHELRSKFGLLDEETQTEVHYVDKKPKLDEQLEFLPE--------ESPY 159
                           ||:|::.:|      .:.::...|.....:|| :|||:        |.|
  Fly   122 QQDAREELKSVLEQINLNEIKIEF------PEADLTIADVLEDQEEQ-DFLPDDCISKEGAEDP- 178

  Fly   160 ELANPLTPEEKQE----SVDQEQDQPTEEPD----------EQDADYEPNEDRVLMSLCD----- 205
            |:.....|..|::    |..:.:.|..|.|:          ::..||.....:|...:|:
  Fly   179 EVLEKKPPTLKRKVSGRSRGRRRVQLAERPNTSCLPKIQKSQEFNDYIREHYKVQCHICNLPMED 243

  Fly   206 ----VYGIQEDNSSAGSLDGSSPSTEKAGEDAADSEKRHQ------CNECLRSYATSKTLQRHLR 260
                :..::.::...|.....:....|.|. ..|..:|||      |:.|.|.....::|:.|:|
  Fly   244 FSEMLAHVRREHKQRGYAMCCNRKFLKRGV-LVDHLRRHQDPETFKCSICGRVMGHRRSLELHMR 307

  Fly   261 QDHGQTEPTTEQLQCPDCPKKFRLHYQLERHMKWHVPLPKRKQY--ACSSCDKKFATSASAQQHE 323
            ..  :.:......:|..|.|.|......|||...|:|   |:|:  .|:.|:|.:.:..:.|||.
  Fly   308 MH--EIKSRGRLYRCEQCSKAFYSAVVYERHKLTHIP---REQWKVPCTHCEKTYPSQYTMQQHV 367

  Fly   324 QYMHLDERPRPVICEQCGVGVHSMSALKEHVLKHT--DYAPFECEVCKKCFKSANRL-KHHKETH 385
            :.:||:...:  ||:.||..:....||..|:.:||  ..|..:|.:|.....:...| :|.|..|
  Fly   368 KLVHLNLYAK--ICDVCGKSIRGREALARHMEEHTGGPQAAIKCHLCDSMLTTKYGLARHIKMMH 430

  Fly   386 DPHKYICPECGMQLNSRTTLNRH----RLVHTDQMQHKCDYCGREFKRAKALKNHLILHTGLKPY 446
            ........:|...|....:|..|    :..|.....|:|..|.:.|||...||.|:..|||...|
  Fly   431 TAENLQPMQCEFCLKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNELKEHMTTHTGEVLY 495

  Fly   447 SCDFCDRTFANGSNCRTHKKKSHPEELAAQEAAGGGRSHNRNIPKLEALKAFTKNKDNLSPVATK 511
            :|..|.:||.:.:|...|:||.|.:|..........||.     |.:.:.|.:..|    ...|:
  Fly   496 TCPHCPQTFNSNANMHAHRKKVHRKEWEENRHKRLNRSR-----KSDTIIAVSVRK----TTETR 551

  Fly   512 QSGCFAFGKKPRPATKDTPASNP 534
            |.|    |..|..|...|  |:|
  Fly   552 QDG----GLVPAEAIATT--SSP 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071	22/87 (25%)
		PTZ00423	131..>230	CDD:240413	21/129 (16%)
		COG5048	<222..408	CDD:227381	50/196 (26%)
		C2H2 Zn finger	242..263	CDD:275368	6/20 (30%)
		C2H2 Zn finger	275..295	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..357	CDD:275368	15/50 (30%)
		C2H2 Zn finger	365..385	CDD:275368	5/20 (25%)
		C2H2 Zn finger	392..412	CDD:275368	4/23 (17%)
		zf-C2H2	418..440	CDD:278523	9/21 (43%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..457	CDD:290200	11/24 (46%)
		C2H2 Zn finger	448..466	CDD:275368	6/17 (35%)
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	15/61 (25%)
		C2H2 Zn finger	264..281	CDD:275368	3/17 (18%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..369	CDD:275368	6/18 (33%)
		C2H2 Zn finger	440..461	CDD:275368	4/20 (20%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471731
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940