DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10366 and kmg

DIOPT Version :9

Sequence 1:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster

Alignment Length:	666	Identity:	119/666 - (17%)
Similarity:	203/666 - (30%)	Gaps:	221/666 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 CRLC--AKDDVQ---GNLNVFLKNEDSGEAASMELATAIGKYFWVNITRGEELPETI-----CSE 83
            |:||  |....|   .::.:.....|.|.|.....|...||.......|...|.|:|     ..:
  Fly   149 CKLCLYASRHFQKLVRHMKMVHGCSDDGGAVQGSGAQPRGKRNLSREVRKRRLEESIEGQGATGQ 213

  Fly    84 CLSL-VTSLVNFSERITRVQKLYCILQSTPSQERPNLHELRSKFGLLDEETQTEVHYVDKKPKLD 147
            ||.| |..::                     |..|.|.:|:.:....:.:....|...:::.::
  Fly   214 CLDLSVLRMI---------------------QNGPPLEQLKVELQQQEMQLLASVQAYNRQQEM- 256

  Fly   148 EQLEFLPE------ESPYELANPLTPEEKQESVDQEQDQPTEEPDEQDADYEPNEDRVLMSLCDV 206
            .||:.:.|      ...||....|.|.::.||:..||...:.:.:|
  Fly   257 LQLQQIVESHDNIFSMAYEFQTKLMPPKQAESLKLEQQNSSSDSEE------------------- 302

  Fly   207 YGIQEDNSSAGSLDGSSPSTEKAGEDAADSEKRHQCNECLRSYATSKTLQRHLRQDHGQTEPTTE 271
                         ...|||.:.  .:....:::.||.:|..|.......::|::..      :..
  Fly   303 -------------TAKSPSPDT--RELVSGKEQFQCQKCSYSTPIRARFKKHVKYH------SMP 346

  Fly   272 QLQCPDCPKKFRLHYQLERHMKWHVPLPKRKQYACSSCDKKFATSASAQQHEQYMHLDERPRPV- 335
            .::|..|.......:.|:||.|.|   .....:.||.||.......|...||...|:   |.||
  Fly   347 LIKCSSCDFHTPYKWNLDRHTKNH---GANGHFKCSCCDFSTDIKQSLTIHESNHHV---PMPVH 405

  Fly   336 ------------ICEQCGVGVHSMSALK---------EHVLKHTDYAPFECEVCKKCFKSANRLK 379
                        :.:|...|.......|         |.:|..|  :...|..|:|...:|.:|.
  Fly   406 QMGNRSRDEAEDLVDQQSSGSRKPETFKNGGATVASTESLLPRT--SGIVCSHCQKRVGNAMQLI 468

  Fly   380 HHKETHDPHKYICPECGMQLNSRT----TLNRHRLVHTDQMQH---------------------- 418
            :|.:.          |.:.|::.|    ::|....:|.:...:
  Fly   469 NHLQV----------CTLALHNTTQLQASINAEVDLHDEDFPNAPTDLSYCGVETAPGYGEVTEV 523

  Fly   419 ---------------KCDYCGREFKRAKALKNHLILHTGLKPYSCDFCDRTFANGSNCR----TH 464
                           ||.:|......|.....|::.|...||:.|..|    |..||.|    .|
  Fly   524 LPEEPEDLAPLKKVFKCPHCSFWAATASRFHVHIVGHLNRKPFECSLC----AYRSNWRWDITKH 584

  Fly   465 ------KKKSHPEELAAQEAAGGGRSHNRNIPKLEALKAFT-------------------KNKDN 504
                  :.:||.:.........|.|::.:....|..:|...                   :..|:
  Fly   585 IRLKALRDRSHNQAQVLMNDETGRRNYAKYNQYLTMMKVSAEQLADSKGMRTGEMIVMPPEKLDD 649

  Fly   505 LSPVATKQ---------SGCFAFGKKPR-PATKDTPASNPAVIQD-AQPEP-------------- 544
            ..|:.|::         |......:||| ..|:|...::..:.|: |:.||
  Fly   650 HHPMETEEIIEMVDSAHSTSALDLRKPRDDQTEDLAGNSDELPQEGAKTEPNLEPLSFKSLNSSQ 714

  Fly   545 -APDPGGE--NATQAD 557
             .|.|.|.  |.|:.|
  Fly   715 VMPKPKGSPMNLTKTD 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071	19/89 (21%)
		PTZ00423	131..>230	CDD:240413	16/104 (15%)
		COG5048	<222..408	CDD:227381	42/211 (20%)
		C2H2 Zn finger	242..263	CDD:275368	4/20 (20%)
		C2H2 Zn finger	275..295	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..357	CDD:275368	16/72 (22%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	4/23 (17%)
		zf-C2H2	418..440	CDD:278523	5/58 (9%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
		zf-H2C2_2	432..457	CDD:290200	6/24 (25%)
		C2H2 Zn finger	448..466	CDD:275368	7/27 (26%)
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	4/19 (21%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444645
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030