DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10366 and Zfp521

DIOPT Version :9

Sequence 1:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_663467.1	Gene:	Zfp521 / 225207	MGIID:	95459	Length:	1311	Species:	Mus musculus

Alignment Length:	493	Identity:	102/493 - (20%)
Similarity:	166/493 - (33%)	Gaps:	138/493 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PET--ICSECLSLVTSLVNFSERITRVQKLYCILQSTPSQERPNLHELRSKFGLLDEETQTEVHY 139
            ||.  ||..||.::.||.|.:|.:.:|                  ||.:.. ||:
Mouse   433 PEQAHICQYCLEVLPSLYNLNEHLKQV------------------HEAQDP-GLI---------- 468

  Fly   140 VDKKPKLDEQLEFLPEESPYELANPLTPEEKQESVDQEQDQPTEEPDEQDADYEPN--------- 195
            |...|.:..|..|..     |:.|.|  ...||.:............:.:|.:.|:
Mouse   469 VSAMPAIVYQCNFCS-----EVVNDL--NTLQEHIRCSHGFANPAAKDSNAFFCPHCYMGFLTDS 526

  Fly   196 --EDRVLMSLCDVYGIQEDNSSAGSLDGSSPSTEKAGEDAADSEKRHQCNECLRS--YATSKTLQ 256
              |:.:....||             |.||...:...|.......:.:.|:.|..|  :.:...|.
Mouse   527 SLEEHIRQVHCD-------------LSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLN 578

  Fly   257 RHLRQDHGQ------------------------TEPTTEQLQ---------------CPDCPKKF 282
            :|::::|..                        .|.||.::.               |..|..|:
Mouse   579 KHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTTLKMMQTVGGGPARASGEYICNQCGAKY 643

  Fly   283 RLHYQLERHMKWHVP--LPKRKQYACSSCDKKFATSASAQQHEQYMHLDERPRPVICEQCGVGVH 345
            ......:.|:|.|:.  |||   ..|..|:|:|....|..:|.. :|........|||.|.....
Mouse   644 TSLDSFQTHLKTHLDTVLPK---LTCPQCNKEFPNQESLLKHVT-IHFMITSTYYICESCDKQFT 704

  Fly   346 SMSALKEHVLKHTDYAPFECEVCKKCFKSANRLKHH---KETHDPHKYICPECGMQLNSRTTLN- 406
            |:..|::|:|....:..|.|.:|::.|.|...::.|   |.:::...|.|..|.....:.|.|.
Mouse   705 SVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQL 769

  Fly   407 --RHRLVHTDQMQHKCDYCGREFKRAKALKNHLILHTGLKPYSCDFCDRTFANGSNCRTHKKKSH 469
              :|..:......|||.:||..|.....|:.|:..|:  |.|:|.||.:.|........|.::.|
Mouse   770 HVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHS--KKYNCRFCSKAFHAVILLEKHLREKH 832

  Fly   470 ---------------PEELAAQEA------AGGGRSHN 486
                           .|::..:||      .....|||
Mouse   833 CVFETKTPNCGTNGASEQVQKEEAELQTLLTNSQESHN 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071	11/32 (34%)
		PTZ00423	131..>230	CDD:240413	17/109 (16%)
		COG5048	<222..408	CDD:227381	47/234 (20%)
		C2H2 Zn finger	242..263	CDD:275368	5/22 (23%)
		C2H2 Zn finger	275..295	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..357	CDD:275368	15/50 (30%)
		C2H2 Zn finger	365..385	CDD:275368	6/22 (27%)
		C2H2 Zn finger	392..412	CDD:275368	5/22 (23%)
		zf-C2H2	418..440	CDD:278523	8/21 (38%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..457	CDD:290200	9/24 (38%)
		C2H2 Zn finger	448..466	CDD:275368	5/17 (29%)
Zfp521	NP_663467.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..108
		COG5048	<83..236	CDD:227381
		C2H2 Zn finger	120..140	CDD:275368
		C2H2 Zn finger	148..168	CDD:275368
		C2H2 Zn finger	176..196	CDD:275368
		C2H2 Zn finger	204..224	CDD:275368
		C2H2 Zn finger	248..265	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..398
		C2H2 Zn finger	407..428	CDD:275368
		C2H2 Zn finger	439..460	CDD:275368	8/38 (21%)
		C2H2 Zn finger	479..498	CDD:275368	6/25 (24%)
		C2H2 Zn finger	636..656	CDD:275368	5/19 (26%)
		C2H2 Zn finger	666..686	CDD:275368	6/20 (30%)
		C2H2 Zn finger	696..713	CDD:275368	5/16 (31%)
		C2H2 Zn finger	724..745	CDD:275368	5/20 (25%)
		C2H2 Zn finger	754..774	CDD:275368	4/19 (21%)
		C2H2 Zn finger	785..805	CDD:275368	6/19 (32%)
		C2H2 Zn finger	811..829	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..883		3/8 (38%)
		C2H2 Zn finger	888..909	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	961..981	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1136
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1258..1279	CDD:275368
		C2H2 Zn finger	1288..1307	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010