Protein Alignment CG10366 and Rest

DIOPT Version :10

• Sequence 1: NP_609995.1
• Gene: CG10366 / 35258
• FlyBaseID: FBgn0032814
• Length: 578
• Species: Drosophila melanogaster
• Sequence 2: NP_035393.2
• Gene: Rest / 19712
• MGIID: 104897
• Length: 1082
• Species: Mus musculus
• Alignment Length: 499
• Identity: 108/499 - (21%)
• Similarity: 168/499 - (33%)
• Gaps: 109/499 - (21%)

  Fly   153 LPEESPYELANP---------LTPEEKQESVDQ---EQDQPTEEPDEQDADYEPNEDRVLMSLCD 205
            |.|.|..|||.|         ||.|......|.   |:.|..|.....|..:..:|...|....|
Mouse    33 LHELSKAELAAPQLIMLANVALTGEASGSCCDYLVGEERQMAELMPVGDNHFSESEGEGLEESAD 97

  Fly   206 VYGIQEDNSSAGSLD------------GSSPSTEKAGEDAA------------DSEKRHQCNECL 246
            :.|:  :|...|||:            .::|....|.:|.|            ...|..:|..|.
Mouse    98 LKGL--ENMELGSLELSAVEPQPVFEASAAPEIYSANKDPAPETPVAEDKCRSSKAKPFRCKPCQ 160

  Fly   247 RSYATSKTLQRHLRQDHGQ------------------TEPTTE------QLQCPDCPKKFRLHYQ 287
            ....:.:....|:|....:                  :.|..|      .::|..|......:..
Mouse   161 YEAESEEQFVHHIRIHSAKKFFVEESAEKQAKAWESGSSPAEEGEFSKGPIRCDRCGYNTNRYDH 225

  Fly   288 LERHMKWHVPLPKRKQ-YACSSCDKKFATSASAQQHEQYMHL-DERPRPV-ICEQCGVGVHSMSA 349
            ...|:|.|:...:.:: |.|..|     |..:..::....|| :..||.| .|.:|.......:.
Mouse   226 YMAHLKHHLRAGENERIYKCIIC-----TYTTVSEYHWRKHLRNHFPRKVYTCSKCNYFSDRKNN 285

  Fly   350 LKEHVLKHTDYAPFECEVCKKCFKSANRLKHHKETHDPHK-YICPECGMQLNSRTTLNRH-RLVH 412
            ..:||..||...|::||:|.........|..|..||...| :.|.:|....:::..:.|| |.||
Mouse   286 YVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNYVASNQHEVTRHARQVH 350

  Fly   413 TDQMQHKCDYCGREFKRAKALKNHLILHTGLKPYSCDFCDRTFANGSNCRTHKKKSHPEELAAQE 477
            .......|.:|..:.......|.|:.||...:.::|..||...:...|.:.|.|..||.
Mouse   351 NGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPT------ 409

  Fly   478 AAGGGRSHNRNIPKLEALKAFTKNKDNLSPVA---------TKQSGCFAFGKKPRPATKDTPASN 533
                ..|...::.|::..|...:..|.|:...         ||..|..: |||.....|
Mouse   410 ----CPSKTMDVSKVKLKKTKKREADLLNNAVSNEKMENEQTKTKGDVS-GKKNEKPVK------ 463

  Fly   534 PAVIQDAQPEPAPDPG----------GENATQADTPAAAIPTLD 567
             ||.:||..|..|...          .::|..|:|.||.:...|
Mouse   464 -AVGKDASKEKKPGSSVSVVQVTTRTRKSAVAAETKAAEVKHTD 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10366	NP_609995.1	zf-AD	28..108	CDD:462262
		COG5048	<222..408	CDD:227381	42/225 (19%)
		C2H2 Zn finger	242..263	CDD:275368	4/20 (20%)
		C2H2 Zn finger	275..295	CDD:275368	4/19 (21%)
		C2H2 Zn finger	306..357	CDD:275368	12/52 (23%)
		C2H2 Zn finger	365..385	CDD:275368	5/19 (26%)
		C2H2 Zn finger	392..412	CDD:275368	5/20 (25%)
		SUF4-like	418..>485	CDD:411020	14/66 (21%)
		C2H2 Zn finger	420..445	CDD:411020	6/24 (25%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
		C2H2 Zn finger	448..469	CDD:411020	6/20 (30%)
		C2H2 Zn finger	448..466	CDD:275368	5/17 (29%)
Rest	NP_035393.2	Interaction with SIN3A. /evidence=ECO:0000250|UniProtKB:Q13127	32..117		23/85 (27%)
		Interaction with SIN3B. /evidence=ECO:0000250|UniProtKB:Q13127	43..57		3/13 (23%)
		Interaction with ZFP90. /evidence=ECO:0000250|UniProtKB:Q13127	140..413		57/287 (20%)
		Required for binding to the neuron-restrictive silencer element. /evidence=ECO:0000269|PubMed:11039732	196..207		2/10 (20%)
		C2H2 Zn finger	245..265	CDD:275368	5/24 (21%)
		COG5048	<266..409	CDD:227381	38/142 (27%)
		C2H2 Zn finger	273..293	CDD:275368	4/19 (21%)
		zf-H2C2_2	285..310	CDD:463886	8/24 (33%)
		zf-H2C2_5	299..323	CDD:404746	7/23 (30%)
		C2H2 Zn finger	301..321	CDD:275368	5/19 (26%)
		zf-H2C2_2	313..338	CDD:463886	7/24 (29%)
		C2H2 Zn finger	329..350	CDD:275368	5/20 (25%)
		C2H2 Zn finger	386..402	CDD:275368	4/15 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..809		25/117 (21%)
		PRK12323	<607..776	CDD:481241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..1027
		Interaction with RCOR1. /evidence=ECO:0000250|UniProtKB:Q13127	985..1063