Protein Alignment PCNA2 and PCNA

DIOPT Version :10

• Sequence 1: NP_609994.1
• Gene: PCNA2 / 35257
• FlyBaseID: FBgn0032813
• Length: 255
• Species: Drosophila melanogaster
• Sequence 2: NP_002583.1
• Gene: PCNA / 5111
• HGNCID: 8729
• Length: 261
• Species: Homo sapiens
• Alignment Length: 259
• Identity: 124/259 - (47%)
• Similarity: 191/259 - (73%)
• Gaps: 5/259 - (1%)

  Fly     1 MLEARLSQTLLLKKIVDALKEIIAQGTLDCSENGLELQSMDNSHVSLVALSLASDCFEKFHCDRN 65
            |.||||.|..:|||:::|||::|.:...|.|.:|:.|||||:||||||.|:|.|:.|:.:.||||
Human     1 MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRN 65

  Fly    66 VSLGLDLKSLGKVLKCANSDDAVTIKAVDRPEKITLSFESDGKERTADYELKLLNLDQDHMEIPK 130
            :::|::|.|:.|:||||.::|.:|::|.|..:.:.|.||:..:|:.:|||:||::||.:.:.||:
Human    66 LAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPE 130

  Fly   131 KDYTCFIQLPSSEFARICRDMSMFDESLTIACSSKGIRFLAKGDLGTANIQLSAGTAMD-----V 190
            ::|:|.:::||.||||||||:|...:::.|:|:..|::|.|.|:||..||:||..:.:|     |
Human   131 QEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAV 195

  Fly   191 SIEVQEPVTQSFAGRYLNTFTKATPLADRVKLYLSDERPLLVEYPIEDYGHIRYYLAPKVNDPD 254
            :||:.|||..:||.||||.|||||||:..|.|.:|.:.||:|||.|.|.||::||||||:.|.:
Human   196 TIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEE 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCNA2	NP_609994.1	beta_clamp	1..254	CDD:478224	124/257 (48%)
PCNA	NP_002583.1	pcna	1..259	CDD:273158	124/257 (48%)
		Interaction with NUDT15. /evidence=ECO:0000269|PubMed:19419956	7..100		42/92 (46%)