DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hakai and CBLL2

DIOPT Version :9

Sequence 1:	NP_001260593.1	Gene:	Hakai / 35256	FlyBaseID:	FBgn0032812	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_689790.1	Gene:	CBLL2 / 158506	HGNCID:	26371	Length:	425	Species:	Homo sapiens

Alignment Length:	350	Identity:	105/350 - (30%)
Similarity:	140/350 - (40%)	Gaps:	99/350 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 KWNH-KVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCARAEP---IKSCPRCTDKV 220
            :|.. |:::||||...| ||.||:||.||.:|||:|||||.||..||....   .|.||||...|
Human    37 RWGDIKINIIGEKDDLP-IHFCDKCDLPIKIYGRIIPCKHAFCYHCANLYDKVGYKVCPRCRYPV 100

  Fly   221 LRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHR------------------HVAP 267
            ||:|....|:||||:.      ...|:||||||:.|||||..|                  |:||
Human   101 LRIEAHKRGSVFMCSI------VQQCKRTYLSQKSLQAHIKRRHKRARKQVTSASLEKVRPHIAP 159

  Fly   268 Q-------PPPLQPQPQLSAM-AEQPKMTDLGGVGLGL-ELHKQRKLSESSVPISVSASIASRPV 323
            .       |..||.:..||.: .||..|..|..|...| |.|.|......:.|..:|.|
Human   160 PQTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSLS------ 218

  Fly   324 LSRLPLTGGVGNIGSIGSIPPPGSAAAAQNAIHGGHSTLTLANLTRINNANAQ---------ECH 379
               ||             .|......:.....||   .||:.::...:::.|:         ||.
Human   219 ---LP-------------FPIQWETVSIFTRKHG---NLTVDHIQNNSDSGAKKPTPPDYYPECQ 264

  Fly   380 QGKA--SLHHTLKK----------GTP--HQ-----SESVADASYYSSVLASFGSAAGNPGSG-- 423
            ...|  |.||.:.:          .:|  ||     .:.|...|..|.|.|.  :...:|.||
Human   265 SQPAVSSPHHIIPQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPAL--TTTYDPSSGYI 327

  Fly   424 ----PPGGGATAAAQPANPSGSHSA 444
                ||...:.....|.:.:|:.||
Human   328 IVKVPPDMNSPPLRAPQSQNGNPSA 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hakai	NP_001260593.1	RING-HC_HAKAI_like	178..216	CDD:319422	22/40 (55%)
Hakai	NP_001260593.1	RING-HC finger (C3HC4-type)	180..216	CDD:319422	21/38 (55%)
CBLL2	NP_689790.1	RING	57..100	CDD:238093	23/42 (55%)
		HYB domain	96..154		23/63 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..297		10/55 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144571
Domainoid	1	1.000	50	1.000	Domainoid score	I11690
eggNOG	1	0.900	-	-		E1_KOG2932
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6974
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005494
OrthoInspector	1	1.000	-	-		otm42225
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13480
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.840