DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spi and Nrg2

DIOPT Version :9

Sequence 1:	NP_001027281.1	Gene:	spi / 35253	FlyBaseID:	FBgn0005672	Length:	234	Species:	Drosophila melanogaster
Sequence 2:	NP_001369349.1	Gene:	Nrg2 / 100042150	MGIID:	1098246	Length:	859	Species:	Mus musculus

Alignment Length:	155	Identity:	36/155 - (23%)
Similarity:	62/155 - (40%)	Gaps:	47/155 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 KCPETFDAWYCLNDAHCFAVKIADLPVYSCECAIGFMGQRC--------------EYKEIDNTYL 131
            ||.||..: ||:|...|:.::  .:...||:|.:|:.|.||              |.||.:..|
Mouse   355 KCNETAKS-YCVNGGVCYYIE--GINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELY- 415

  Fly   132 PKRPRPMLEKASIASGAMC-ALVFMLFVCLAFYLRFEQRAAKKAYELEQELQQEYDDDDGQCECC 195
                    :|..:....:| ||:.:..||:..|.:.:::..:..:.|.|.:          |...
Mouse   416 --------QKRVLTITGICVALLVVGIVCVVAYCKTKKQRRQMHHHLRQNM----------CPAH 462

  Fly   196 RNRCCPDGQEPVILERKLPYHMRLE 220
            :||...:|          |.|.||:
Mouse   463 QNRSLANG----------PSHPRLD 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spi	NP_001027281.1	None
Nrg2	NP_001369349.1	Ig_Pro_neuregulin	248..339	CDD:409408
		Ig strand B	264..268	CDD:409408
		Ig strand C	278..282	CDD:409408
		Ig strand E	305..309	CDD:409408
		Ig strand F	319..324	CDD:409408
		Ig strand G	332..335	CDD:409408
		PHA02887	<354..397	CDD:165214	15/44 (34%)
		Neuregulin	443..840	CDD:396641	10/55 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910