Protein Alignment Tep4 and yfhM

DIOPT Version :9

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_417015.1
• Gene: yfhM / 947302
• ECOCYCID: G7323
• Length: 1653
• Species: Escherichia coli
• Alignment Length: 1655
• Identity: 311/1655 - (18%)
• Similarity: 523/1655 - (31%)
• Gaps: 618/1655 - (37%)

  Fly    28 GKYTIVGPGT--------IHSHRDYNVAVAVHQTKEPVTLKVGITGPSYN-KTETVELATA---- 79
            |:|....|.|        :.:||.:|......|:.|....:.||.....| |.:|:..||:
E. coli   276 GRYDYSNPATLFTLSDIGVSAHRYHNRLDIFTQSLENGAAQQGIEVSLLNEKGQTLTQATSDAQG 340

  Fly    80 ------------------GEFKQITFKLPPLEAGEYNLT-AEGVKGLEFKNSTKLNWENFKPYIK 125
                              |:...:..|||.|:..|:|:. |.|.....|.         |.|
E. coli   341 HVQLENDKNAALLLARKDGQTTLLDLKLPALDLAEFNIAGAPGYSKQFFM---------FGP--- 393

  Fly   126 IQTDKGKYKPGDTINYRVIFLD--------ENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGG 182
                :..|:||:|:....:..|        :.::.|..|.:..|     .|:.:.|.::     |
E. coli   394 ----RDLYRPGETVILNGLLRDADGKALPNQPIKLDVIKPDGQV-----LRSVVSQPEN-----G 444

  Fly   183 VYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPK 247
            :|...:.|...|..|.|.:....||..:                ..|       :|.||.::..:
E. coli   445 LYHFTWPLDSNAATGMWHIRANTGDNQY----------------RMW-------DFHVEDFMPER 486

  Fly   248 YSVKM--DATQQVSVRDGEFNVVLKANYTYGKPVNGKVL-----VNVHLDSTSSWENVD-GKTVQ 304
            .::.:  :.|......:.:|:||  ..|.||.|.||..|     :....::.|:....: |
E. coli   487 MALNLTGEKTPLTPKDEVKFSVV--GYYLYGAPANGNTLQGQLFLRPLREAVSALPGFEFG---- 545

  Fly   305 TDYPGHSVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLY 369
             |....::..|.|.|    :||:|.|.....   .|.|.:.:..:.::..|.| .|.|:||
E. coli   546 -DIAAENLSRTLDEV----QLTLDDKGRGEV---STESQWKETHSPLQVIFQG-SLLESGG---- 597

  Fly   370 PYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYA---FYAFG 431
                             :|.....               .:::..|....|||..:|   .|.:.
E. coli   598 -----------------RPVTRRA---------------EQAIWPADALPGIRPQFASKSVYDYR 630

  Fly   432 TDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYP 496
            ||      .|:::.  :.:...||:    |.:|..|...:.....  .:::..:.|:||.|..:.
E. coli   631 TD------STVKQP--IVDEGSNAA----FDIVYSDAQGVKKAVS--GLQVRLIRERRDYYWNWS 681

  Fly   497 YREPKQ--------IENPSSEEEK-----------EW--FRAEVQRPKDV-----------W--- 526
            ..|..|        |||..:.:.|           ||  :|.||:.|.:.           |
E. coli   682 EDEGWQSQFDQKDLIENEQTLDLKADETGKVSFPVEWGAYRLEVKAPNEAVSSVRFWAGYSWQDN 746

  Fly   527 ------------NLKI--------------------GQEYQVILNSSRPLKYFVYNIVGRGNILE 559
                        .||:                    |:.|.::.:|..||.:...::..:|..|.
E. coli   747 SDGSGAVRPDRVTLKLDKASYRPGDTIKLHIAAPTAGKGYAMVESSEGPLWWQEIDVRAQGLDLT 811

  Fly   560 T------KRVDL---------------AEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTE 603
            .      .|.||               |.|:..|.|      |..|.|       ||....
E. coli   812 IPVDKTWNRHDLYLSTLVVRPGDKSRSATPKRAVGV------LHLPLG-------DENRRL---- 859

  Fly   604 ETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKS-----FVGLL--AVDQSVLLLGSNNDLN 661
                       .:.::.||:::|...:.::||.|.|:     .|.:|  |||..||
E. coli   860 -----------DLALETPAKMRPNQPLTVKIKASTKNGEKPKQVNVLVSAVDSGVL--------- 904

  Fly   662 KESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPD----YNILTEG------- 715
                  .:..|.|..|||                  |:|...|...|    |..:.||
E. coli   905 ------NITDYVTPDPWQ------------------AFFGQKRYGADIYDIYGQVIEGQGRLAAL 945

  Fly   716 -FGGSSFAMR---KTTVAHDSHVF---------HSGAGGPTQAVG-FSAESASASAAPVVRKNFA 766
             |||....::   |..|.|.:.|.         ..|.|..|..:| |:.|          .:..|
E. coli   946 RFGGDGDELKRGGKPPVNHVNIVVQQALPVTLNEQGEGSVTLPIGDFNGE----------LRVMA 1000

  Fly   767 ETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPY 831
            :.|...|..|.|.:|              :|..                      |....:.:|.
E. coli  1001 QAWTADDFGSNESKV--------------IVAA----------------------PVIAELNMPR 1029

  Fly   832 SVKRGEVINVPALVFNYL--PKTLDVELTLDNEDQEYDFVDASN--EVIGDQKRTQNIRVGANEA 892
            .:..|:...:...:.|..  |:.|:|.||            ||.  |::.|
E. coli  1030 FMASGDTSRLTLDITNLTDKPQKLNVALT------------ASGLLELVSD-------------- 1068

  Fly   893 AGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKNTFE- 956
            :.|:..:.|.|...:.:..:|: |..||                            ||.:.|..
E. coli  1069 SPAAVELAPGVRTTLFIPVRAL-PGYGD----------------------------GEIQATISG 1104

  Fly   957 LEVPEDVVPD--------------SERVEFG-----------------------LVGDLL----G 980
            |.:|.:.|.|              ::.|.:|                       |.|.||    .
E. coli  1105 LALPGETVADQHKQWKIGVRPAFPAQTVNYGTALQPGETWAIPADGLQNFSPVTLEGQLLLSGKP 1169

  Fly   981 P--VVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYR 1043
            |  :.:.::.|...|.||.|||.|.|.|:............:....|.:.:.::..|...:|..:
E. coli  1170 PLNIARYIKELKAYPYGCLEQTASGLFPSLYTNAAQLQALGIKGDSDEKRRASVDIGISRLLQMQ 1234

  Fly  1044 HDDGSFSSFGPTKWRQEDPVRNGST--WLTAYVL--------RSFSKIKDIIDLDEQILAKGYEF 1098
            .|:|.|:.:.          :||..  ||||||:        :.:|...|.|:       :|.|.
E. coli  1235 RDNGGFALWD----------KNGDEEYWLTAYVMDFLVRAGEQGYSVPTDAIN-------RGNER 1282

  Fly  1099 LLTRQAENGSFTEHGEYFYSSQRSLLTLTANSLLALLEEEKPNQAAIDKAVAYLSANTAESIELL 1163
            ||....:.|..:.  .|..:.:.|...:.:.:.|.|..::|....|: :.:....|:.|..:.||
E. coli  1283 LLRYLQDPGMMSI--PYADNLKASKFAVQSYAALVLARQQKAPLGAL-REIWEHRADAASGLPLL 1344

  Fly  1164 PKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEIT 1228
            ...:|:..:..|...|.|..:| ||: .::.|:|.|..:....||                   .
E. coli  1345 QLGVALKTMGDATRGEEAIALA-LKT-PRNSDERIWLGDYGSSLR-------------------D 1388

  Fly  1229 SYALLSLLDSDQETAD---SVLNTV-------RWLIAQRNGFGGFASSQDTVVGLTALIKFAEKS 1283
            :..:||||:.::...|   ::|||:       |||..|.:               .||...|...
E. coli  1389 NALMLSLLEENKLLPDEQYTLLNTLSQQAFGERWLSTQES---------------NALFLAARTI 1438

  Fly  1284 GYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVE-----------------FPQGTK----- 1326
            .....||:...|...::...||...|..|...|.|::                 :||...
E. coli  1439 QDLPGKWQAQTSFSAEQLTGEKAQNSNLNSDQLVTLQVSNSGDQPLWLRMDASGYPQSAPLPANN 1503

  Fly  1327 --SLEFEAKGTGAAMVQI----SYQYNLVEKEPKPSFKIQTTVLPESSPANLELSVCVDYVEEGE 1385
              .:|....||......:    |....||..:.|.|..:...::.:..||.|||
E. coli  1504 VLQIERHILGTDGKSKSLDSLRSGDLVLVWLQVKASNSVPDALVVDLLPAGLEL----------- 1557

  Fly  1386 SKESNMAILEVSLPSGYTADEDSFADIRNI 1415
             :..|:|       :|..:.|.|..:::|:
E. coli  1558 -ENQNLA-------NGSASLEQSGGEVQNL 1579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	18/100 (18%)
		A2M_N_2	528..653	CDD:285005	34/172 (20%)
		A2M	768..859	CDD:278630	14/92 (15%)
		A2M_2	982..1279	CDD:239227	68/316 (22%)
		A2M_comp	1035..1281	CDD:284982	57/265 (22%)
		A2M_recep	1389..1479	CDD:284981	6/27 (22%)
yfhM	NP_417015.1	YfaS	1..1653	CDD:225248	311/1655 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	1	1.000	-	-
Inparanoid	1	1.050	76	1.000	Inparanoid score	I382
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	4	4.050