DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep4 and c4b

DIOPT Version :9

Sequence 1:NP_001260590.1 Gene:Tep4 / 35248 FlyBaseID:FBgn0041180 Length:1498 Species:Drosophila melanogaster
Sequence 2:NP_001352066.1 Gene:c4b / 794635 ZFINID:ZDB-GENE-100805-2 Length:1717 Species:Danio rerio


Alignment Length:1714 Identity:385/1714 - (22%)
Similarity:676/1714 - (39%) Gaps:422/1714 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 KYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVG--ITGPSYN---------------------- 69
            ::.|..|...|        |.|   |||:.::||  :.|...:                      
Zfish    26 RFLITAPSVFH--------VGV---KEPIVIQVGEALVGKPVSCQLETETRVPMSAKETKTIHQK 79

  Fly    70 -KTETVELA----TAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTD 129
             |.|||.|.    |....|.|..:.|.|     ||..| |.|.  :..|::.......||.||||
Zfish    80 GKFETVNLEIFANTVSNLKSINGEPPYL-----NLACE-VDGQ--RQQTRVLVSKHNGYIFIQTD 136

  Fly   130 KGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFE--DSKRNRIKQEKHIKTTGGVYTGKFELSE 192
            :..|.|...:.:|:..||.::||   |.|:.|:..  ::..|::|:.|: :...|:.:..:::.:
Zfish   137 QPIYNPTQKVRFRIFTLDHSMRP---KLEMYVYVSIYNADGNKVKKSKY-RVLDGILSKDYKIPD 197

  Fly   193 FATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVN-----FEVEKYVLPKYSVKM 252
            .:..|.|.:..                          |..|::.|     |:|:|:|||.:.|.:
Zfish   198 VSKPGVWKITA--------------------------HYEDDVDNAAVREFKVQKFVLPSFGVSV 236

  Fly   253 DATQ---QVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVG 314
            .:.:   |.:.:...|.:  :|:|:|||.::|.......:....|..:.:.:.::      .:..
Zfish   237 HSEKAFLQANAKTLTFTI--QASYSYGKTIDGGFHCRFGIKKGKSENDPEIEFIK------GLEK 293

  Fly   315 TADMVGGKAKLTMDLKDFASYLPH-----KTSSSYAQITATVEEDFTG-VKLNETG-GVQLYPYR 372
            |..:..|.||:|:::.|....|..     .|:.:...|:|||.:..:| |:.:||. .|.|..|.
Zfish   294 TGSVKEGLAKITVNISDITQKLDTALEELATTQTQFYISATVTDILSGEVQESETFLPVVLSRYN 358

  Fly   373 YEMSCTD--YSSCFSFK-----------PDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRN 424
            .::|.|.  |:..|..:           |.:..::...::.      :..||.:.....|||   
Zfish   359 VDLSRTRLFYTPAFPLQAVVTVRHPNGSPAEGVQVKLDVSN------SKEKSTIVTTNKEGI--- 414

  Fly   425 YAFYAFGTDHQEPEL---PTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVD 486
             |||:|..|.:.|.:   .|::....:...|       |.|         :....|.|:..:.:.
Zfish   415 -AFYSFNLDGKPPSVLVQATVDNAKSIRAVH-------PMK---------STSFLYMSVTNKVLS 462

  Fly   487 EKRDLYTT-YPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYN 550
            ..:.|..: ||...|:.                            ||.|              |.
Zfish   463 SGQFLEVSFYPKGNPED----------------------------GQIY--------------YM 485

  Fly   551 IVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQ 615
            ||.||.:..|..| .:..:...::.|.|. :|..:..:.|||:.| |:.........||.....:
Zfish   486 IVSRGMLRSTGSV-ASGSEVKKSIQIHPN-MTPSFRLIAFYYIKE-GDIIADSVWVDVEDTCDGE 547

  Fly   616 IEIKA-------PAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYD 673
            .|:|.       ..|.:..|::.:::.....:.|.|..||:::..||:.|.|.::.....:..||
Zfish   548 FEVKLHHNYGNHNYEPESTAELDIDVGQQKNAKVALQVVDKAIYALGAQNKLTQKQVFASMKSYD 612

  Fly   674 TSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFG-GSSFAMRKTTVAHDSHVFHS 737
            .      |.||..||.|..|.......|.:.:....:.:.:||. .|.|...|..:...:.:...
Zfish   613 L------GCSYGGGENTAAVFNDAGLAFISHSTTIRSAMRKGFSCESGFRRNKREIDVQAEMARK 671

  Fly   738 GA-------------GGPTQAVGFSAESASASAAPVVRKN----FAETWIFA------------- 772
            .|             |.....:.|:.:..:...:....|:    |.|...||             
Zfish   672 EAAFKKTELQKCCRHGFTLIPMKFTCDERAKRVSKTESKDCVNAFRECCEFATKLRDKKRREDMR 736

  Fly   773 -----DIESTE-EEVFKW-------------------VK-------TIPDTITNWVVTGFSLHPQ 805
                 .|.|.| ||.|.:                   ||       .:|.:||.|.:...||.|.
Zfish   737 TGHGRTINSNEVEEFFDFEIQNIRHYFPPSFEFKQIDVKGKVRHRIHLPHSITTWEIQALSLSPS 801

  Fly   806 KGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVD 870
            .|..|. :..::..|:|.|:|:||||||||.|.:::.|::|||  ..:::||.:  ..::.|.:.
Zfish   802 HGFCVA-EPVDLTAFKPVFISLRLPYSVKRYEQLSIVAVIFNY--GKMEMELVV--RMRQVDGLC 861

  Fly   871 ASNEVIGDQKRTQNIRVGANEAAG--ASFLIRPKVIGNI---LLKFKAISPLAGDAIHKPLKVVP 930
            :.    |....:.::|.....|:.  .:|...|.|.|.|   :..:.....:..|||.|.|.|..
Zfish   862 SP----GSATSSSSVRFSLKPASSQTVTFPAVPMVKGEIPITIAIYDIEEKIEVDAIQKILLVKN 922

  Fly   931 EGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSE-----RVEFGLVGDLLG-PVVKN--LE 987
            ||:...:...:.|||....:.:.:.....|.:.||:::     ::|..:...... |::.:  :|
Zfish   923 EGVEMREELTYLINLDGRSDHRLSINGFFPNNTVPETDVNLFVKLEEEIFAQSTAVPLLSSSKVE 987

  Fly   988 NLLRLPSGCGEQTMSKLVPNYLVRDYL-KSIKKLTPALDTRIKR--NLQDGYQHMLHYRHDDGSF 1049
            ||::.|.|||||||..:.|..|...|| ||.:.|.....:|.|.  .::..|:.:|.::..|||:
Zfish   988 NLIQAPKGCGEQTMIFMSPTALSIRYLDKSQRWLELEAGSRDKALDFIEQAYERILTFKKTDGSY 1052

  Fly  1050 SSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKD-IID-----------LDEQILAKGYEFLLTR 1102
            .:     |.|...    ||||||.|::..|.:.: .|:           :.::.:.:...:|:..
Zfish  1053 GA-----WIQTPT----STWLTALVVKVLSLVAERQIETRQQHGTTERMISQEDIRQAVTYLIKT 1108

  Fly  1103 QAENGSFTE-HGEYFYSSQRSL------LTLTANSLLAL------LEEEKPNQAAIDKAVAYLSA 1154
            |..:||||: |..|....|..:      .:|||...:||      |::|   ..|:.:::|..:.
Zfish  1109 QRSDGSFTDAHPVYHREMQGGIGGVEQDASLTAFITIALCRSMPFLDQE---ATAVSQSIARATN 1170

  Fly  1155 NTAESIELL--PKSIAI--YAL-----QKAKAPEAAKQVASLKSLAKHEDDRTWWTED-----LD 1205
            ...:.::.|  |.::||  |.|     ::.:|..|.|:   |:||.|.|.|...|.:|     ::
Zfish  1171 FLLKRVDNLKRPYALAITAYCLSTCLTERTQALSAWKK---LQSLGKPEGDCLVWQDDDDVRLVN 1232

  Fly  1206 KLRASKNCGRWWCWIWSQDVEITSYALL-SLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDT 1269
            :.::::...|     .:..||.|:|||| :|..||.:||.|   .|.:|.:|.|..|||.|:|||
Zfish  1233 EAKSNRVPHR-----VALKVETTAYALLTALAHSDLKTAQS---AVCFLSSQENYEGGFKSTQDT 1289

  Fly  1270 VVGLTALIKFA---EKSGYEAAKWEVTVSNKGKREKTEKLNTSE-ENDLLLQTVEFPQGTKSLEF 1330
            :|.|.||.::|   .::.......:.||:.   |.:.||:|..: ||.:..:.........::..
Zfish  1290 IVALEALSEYALSLPETPITTINAQFTVTG---RSEMEKMNLEKSENKVEAELKRLVGQEINVNL 1351

  Fly  1331 EAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTV-------------------------------L 1364
            ..||.....|..:| |.|.|........|..||                               |
Zfish  1352 SGKGKAKMKVAKAY-YTLKEDGNCADLSINVTVVGKVEYTSVVQEDYNYYEDYGQAEETNEEEDL 1415

  Fly  1365 PES------------------SPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFAD 1411
            |.|                  :..::..:|||.:.:  ..|.|.|||.:::|.||:.|.......
Zfish  1416 PRSAIEWFDARSRQKRETSKNTKEDVVYTVCVSHTQ--GRKLSGMAIADITLLSGFEAINTDLEK 1478

  Fly  1412 IRNI--ERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKK 1474
            ::.:  :.:...|...|.  |::|| |.....|.||...|.::..:...:|:..:.||||:.:::
Zfish  1479 LKGLVDKYISHYEVTRGR--VLLYF-NEIDGGEACIAFGAEQSVPIGLVQPAPALFYDYYEPDRR 1540

  Fly  1475 ATEYYSI--KSKLCDI-CEGDDCK 1495
            .:..||.  :||:..: |..|.|:
Zfish  1541 CSVLYSAPKRSKMVSVLCSDDVCQ 1564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep4NP_001260590.1 A2M_N 126..219 CDD:280081 20/94 (21%)
A2M_N_2 528..653 CDD:285005 28/131 (21%)
A2M 768..859 CDD:278630 38/135 (28%)
A2M_2 982..1279 CDD:239227 100/341 (29%)
A2M_comp 1035..1281 CDD:284982 81/288 (28%)
A2M_recep 1389..1479 CDD:284981 23/91 (25%)
c4bNP_001352066.1 A2M_N 130..224 CDD:307790 26/123 (21%)
A2M_N_2 452..593 CDD:311575 34/185 (18%)
ANATO 667..735 CDD:237984 8/67 (12%)
A2M 772..854 CDD:306673 30/86 (35%)
complement_C3_C4_C5 982..1299 CDD:239226 100/339 (29%)
A2M_recep 1456..1545 CDD:311553 23/91 (25%)
NTR_complement_C4 1563..1715 CDD:239639 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584119
Domainoid 1 1.000 48 1.000 Domainoid score I11904
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
76.810

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