Protein Alignment Tep4 and si:dkey-46g23.2

DIOPT Version :9

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_021327775.1
• Gene: si:dkey-46g23.2 / 793100
• ZFINID: ZDB-GENE-070705-476
• Length: 1359
• Species: Danio rerio
• Alignment Length: 1555
• Identity: 406/1555 - (26%)
• Similarity: 648/1555 - (41%)
• Gaps: 358/1555 - (23%)

  Fly    83 KQITFKLPPLEAGEYNLTAE-GVKGLEFK--NSTKLNWENFKPYIKIQTDKGKYKPGDTINYRVI 144
            :.:.:.|.||.:|:...|.. .|:|..||  ...|:.:.::.|...|||||..|.||.|:|:||:
Zfish     3 EDMKYDLAPLVSGDSVQTVRVVVQGQSFKMTEERKVMFRSYLPLTFIQTDKPLYNPGQTVNFRVV 67

  Fly   145 FLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQH 209
            .:.:.|.|......:|| .||.:..||.|..::.:...:......|...|.:|:::|..
Zfish    68 TMSDKLVPLDQMYNLVV-LEDFRNIRINQWTNVSSVNWILELSHVLIPEAQVGTYTLRA------ 125

  Fly   210 HDGGIYFGGRKQFGGFGHRWHRSDELV--NFEVEKYVLPKYSVKMDATQQVSVRDGEFNVVLKAN 272
                 |.|               |.::  :|:|::|||||:.|.::|.|..||.|....|.....
Zfish   126 -----YIG---------------DRIISQSFDVKQYVLPKFDVTVNAPQTYSVADVGLKVEACGK 170

  Fly   273 YTYGKPVNGKVLVNV-----------------HLDSTSSWENVDGKTVQTDYPGHSVVGTADMVG 320
            ||:|:||.|:|||.|                 .:.||        ||..|
Zfish   171 YTFGQPVPGQVLVEVCRQPFTFAQDPKVTSICLIKST--------KTNNT--------------- 212

  Fly   321 GKAKLTMDLKDF--ASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSC 383
            |.|.||:....|  .|:..:..:|....:..|  |:.|||.::::..|.:   .:|:.
Zfish   213 GCASLTLSTSSFFGTSFESNLQNSFVVNVNLT--EEGTGVVMSKSTTVSI---TFEVG------- 265

  Fly   384 FSFKPDKEHELNFKITYVD-------GSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPT 441
                         |:|:||       ||.:....||  :.|......:.|.|...:        :
Zfish   266 -------------KVTFVDLPKFYNYGSTVNGKISV--SDFNGNPINSKAVYLLDS--------S 307

  Fly   442 IEKKTFVFESHLNASGVAPFKVVLPDLPD-----IANFT--RYYSIELEFVDEKRDLYTTYPYRE 499
            |.....:|....|.:|.|.|.:.....|.     :|:.|  .|:|....:       :||    :
Zfish   308 IWPNKLLFNLTTNKNGFAKFSLDTTSFPQADLNLVASATPQSYFSSNSPY-------FTT----D 361

  Fly   500 PKQIENPSSEEEKEWFR----AEVQRPKDVWNLKIGQEYQVILNSSRPLKY------------FV 548
            .:.::...::.:...|.    .::::|     ||.|..|.|      .:||            .:
Zfish   362 SQVVQLSQTDPDTPTFSDLSIVKLEQP-----LKCGTTYSV------TVKYLFVGETGDYSADII 415

  Fly   549 YNIVGRGNIL----ETKRVDLAEPQTTVNVTIKPTFLT--TPYGRVYFYYV-----DETGEFRY- 601
            |.::.||.|:    :|.:...:...|...||...:.|.  .|..::..|.|     ..||...:
Zfish   416 YMVMSRGVIVLHGFKTVQARASNTLTKGTVTFDLSILAKMAPVVQILVYSVLPSQTVVTGSALFD 480

  Fly   602 TEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKES-F 665
            ||:.|:.:|.||     .:||...||....|.:.....|..||.|:|||||::.|...|:.|: |
Zfish   481 TEKCFANQVSLQ-----FSPASAVPGEGSILTVSAQAGSLCGLSAIDQSVLIMQSGGRLSAEAVF 540

  Fly   666 NW----RLNGYD---------------TSTPWQGGYSYYPGERTGVVTMTNA------------Y 699
            |.    .|:.|.               .:.|....|:.:  :..|:...||.            .
Zfish   541 NMLPLQSLSDYPFGAEDQQNCLNVRPRRAVPTDQAYNTF--KSVGIKIATNLPVREPECLKFKDL 603

  Fly   700 FFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVV--R 762
            .:|           ..|.| .|.:|:...|         ..|...|....||.|....:.||  |
Zfish   604 LYY-----------RNFHG-VFPLREVAFA---------VSGKAPAPLAMAEMAGTGGSSVVTLR 647

  Fly   763 KNFAETWIF-----ADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQP 822
            ..|.||||:     .|..||...:     |:|||||.|....|.| ...|.|:. ....:.:|||
Zfish   648 TYFPETWIWQLSLVGDSGSTSVPL-----TVPDTITTWDTEAFCL-SSNGFGLA-PPALLTSFQP 705

  Fly   823 FFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRV 887
            ||:.:.||||:.|||...:.|.|||||.:.:.:::| ......|....     |.||..:   .:
Zfish   706 FFLELTLPYSIIRGEAFELVATVFNYLLQCIKIQVT-PTPSSNYTLTP-----INDQSSS---TL 761

  Fly   888 GANEAAGASFLIRPKVIGNILLKFKA-ISP---LAG------------DAIHKPLKVVPEGITQY 936
            ..|......:.:...|||.:.:...| .||   |.|            |.:.:.|:|:.||:.:.
Zfish   762 STNWRKTIKWALTASVIGTVNVTISAEASPSQELCGDQDVTVPSRGRIDIVTRSLRVLAEGVERT 826

  Fly   937 QNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTM 1001
            ..|::.:..|.: ....:.::.:|.:|:..|......::||::|..:.||.|||::|||||||.|
Zfish   827 FTRSWLLCPKGS-MLSESVKITLPTNVIQGSASCSVSVIGDIMGRALNNLANLLQMPSGCGEQNM 890

  Fly  1002 SKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNG 1066
            ..|.||..:..||....:||||:.......|..|||..|:|||.|||||:||      .||   .
Zfish   891 IILAPNVYILRYLTVTAQLTPAIRDTATGYLLTGYQGQLNYRHSDGSFSTFG------YDP---S 946

  Fly  1067 STWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQR----SLLTLT 1127
            :|||||:|:|:|...:....:|..:||....:|::.|..:|.|.:.|..:::..:    ..:|:|
Zfish   947 NTWLTAFVMRTFGLARSFTYIDPNVLAGAKNWLISTQGSDGCFVQQGTLYHNDMKGGVGDNVTMT 1011

  Fly  1128 ANSLLALLEEEKP-NQAAIDKAVAYLS------ANTAESIELLPKSIAIYALQKAKAPEAAKQVA 1185
            ...:.:|||...| ....|.||:::|.      .||..: .||..:.::    ..:....|:.::
Zfish  1012 GYIVASLLEIGVPVTDPVITKALSFLRPLVGNLGNTYVT-ALLAHTFSL----AGETNTRAQLLS 1071

  Fly  1186 SLKSLAKHEDDRTWWTEDL--DKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQET------ 1242
            ||::.|..|.....|::..  |.|.                |||::|.||::|.....|
Zfish  1072 SLRNTAISEGTTLHWSQTTSGDTLA----------------VEISAYVLLAVLTVQPVTTANLGY 1120

  Fly  1243 ADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLN 1307
            |:.::|   |::||:|.:|||:|:|||||.|.||..:|.::........|||.:...........
Zfish  1121 ANRIVN---WIVAQQNPYGGFSSTQDTVVALQALALYAAQAFTPGGSSTVTVQSSVPAGDIFNFA 1182

  Fly  1308 TSEENDLLLQ---TVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLP---- 1365
            .:..|.||.|   ...|| ||.|:  .|:|:..|.||::..||:    |.|....:|..:.
Zfish  1183 VTPNNRLLYQRNSLNNFP-GTYSV--VARGSACASVQVACFYNI----PTPVMVARTLSVVAKVS 1240

  Fly  1366 ---ESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADED------SFADIRNIERVRLV 1421
               :::|.||.|:..|.|  .|....:||.::::.:.||:|||..      :||.:  ::||
Zfish  1241 GDCQAAPVNLMLTFTVKY--NGRKPTTNMVLVDIKVLSGFTADTSLLGSPPNFAPL--VQRV--- 1298

  Fly  1422 ETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKK-ATEYYS 1480
             ..|||.|:| |.:.:.|.......|:..:|.||.|.||:.:.:||||..|.| .|.|.|
Zfish  1299 -DSNGDHVLV-YLQEVPKGVPVTFSIQLTQTVAVQNLKPAVINIYDYYQRNDKFETTYKS 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	27/92 (29%)
		A2M_N_2	528..653	CDD:285005	40/148 (27%)
		A2M	768..859	CDD:278630	35/95 (37%)
		A2M_2	982..1279	CDD:239227	103/315 (33%)
		A2M_comp	1035..1281	CDD:284982	80/264 (30%)
		A2M_recep	1389..1479	CDD:284981	32/96 (33%)
si:dkey-46g23.2	XP_021327775.1	A2M_N	47..138	CDD:307790	29/117 (25%)
		A2M_N_2	380..528	CDD:311575	42/163 (26%)
		A2M	653..741	CDD:306673	35/94 (37%)
		A2M_2	871..1146	CDD:239227	98/307 (32%)
		A2M_recep	1265..1354	CDD:311553	32/95 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584171
Domainoid	1	1.000	217	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6406
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.700