DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and C4A

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_009224.2	Gene:	C4A / 720	HGNCID:	1323	Length:	1744	Species:	Homo sapiens

Alignment Length:	1737	Identity:	387/1737 - (22%)
Similarity:	643/1737 - (37%)	Gaps:	436/1737 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IVGPGTIHSHRDYNVAVAVHQTKEPVTLK--VGITGPSYNKTE-----TVELATAGEFKQITFKL 89
            :..|..:|.....:|.|.:........:|  |.:..||.|...     ...|::..:|..::.::
Human    25 LFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSSERDFALLSLQV 89

  Fly    90 P-----------PLEAGEYNLTAE------------GVKGLEFKNSTKLNWENFKPYIKIQTDKG 131
            |           .|...|..|.|.            .::|:....|::      :.::.:|||:.
Human    90 PLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSR------RGHLFLQTDQP 148

  Fly   132 KYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATL 196
            .|.||..:.|||..||:.:||.|  |.:.|..|:|...|:: :|.:.....::...|.:.:.:..
Human   149 IYNPGQRVRYRVFALDQKMRPST--DTITVMVENSHGLRVR-KKEVYMPSSIFQDDFVIPDISEP 210

  Fly   197 GSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQ----Q 257
            |:|.:..:..|     |:                .|:....|||:|||||.:.||:...:    .
Human   211 GTWKISARFSD-----GL----------------ESNSSTQFEVKKYVLPNFEVKITPGKPYILT 254

  Fly   258 VSVRDGEFNVVLKANYTYGKPVNGKVLVNVHL----DSTSSWENVDGKTVQTDYPGHSVVGTADM 318
            |.....|..:.::|.|.|||||.|...|...|    ...:.:..::.:|...:...|..:..|:.
Human   255 VPGHLDEMQLDIQARYIYGKPVQGVAYVRFGLLDEDGKKTFFRGLESQTKLVNGQSHISLSKAEF 319

  Fly   319 VGGKAKLTM---DLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLY----PYRYEMS 376
            .....||.|   ||:....|           :.|.:.|. .|.::.|......|    |:..::|
Human   320 QDALEKLNMGITDLQGLRLY-----------VAAAIIES-PGGEMEEAELTSWYFVSSPFSLDLS 372

  Fly   377 CTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPT 441
            .|..    ...|.....|...:..:.||..:.....|.|             ...:....||:..
Human   373 KTKR----HLVPGAPFLLQALVREMSGSPASGIPVKVSA-------------TVSSPGSVPEVQD 420

  Fly   442 IEKKTFVFESHLNASGVAPFKVVLPDL--------------PDIANFTRYYSIELEFVDEKRDLY 492
            |::.|       :.||.....:::|..              |.||..|                .
Human   421 IQQNT-------DGSGQVSIPIIIPQTISELQLSVSAGSPHPAIARLT----------------V 462

  Fly   493 TTYPYREP--KQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRG 555
            ...|...|  ..||.|.|..         .|..|..||.:.     .:.|.....::.|.|:.||
Human   463 AAPPSGGPGFLSIERPDSRP---------PRVGDTLNLNLR-----AVGSGATFSHYYYMILSRG 513

  Fly   556 NILETKRVDLAEPQ---TTVNVTIKPTFLTTPYGRVYFYYVDE--TGEFRYTEETFSVEVELQNQ 615
            .|:...|    ||:   |:|:|.:......:.|...::|:.|.  ....|...:..:.|.:|  :
Human   514 QIVFMNR----EPKRTLTSVSVFVDHHLAPSFYFVAFYYHGDHPVANSLRVDVQAGACEGKL--E 572

  Fly   616 IEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLG--SNNDLNKESFNWRLNGYDTSTPW 678
            :.:....:.:.|..|.|.::|...:.|.|.|:|.::...|  |:..||.......:|.||.....
Human   573 LSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKPLNMGKVFEAMNSYDLGCGP 637

  Fly   679 QGGYSYY-------------------------PGERT---------------------------- 690
            .||.|..                         |.|:|
Human   638 GGGDSALQVFQAAGLAFSDGDQWTLSRKRLSCPKEKTTRKKRNVNFQKAINEKLGQYASPTAKRC 702

  Fly   691 ---GVVTMTNAYFFYNRTA----PDYNILTEGF-GGSSFAMRKTTVAHDSHVFHSGAGGPTQAVG 747
               ||..:........|.|    ||   ..|.| ....||......:.|     .|..|..:|:.
Human   703 CQDGVTRLPMMRSCEQRAARVQQPD---CREPFLSCCQFAESLRKKSRD-----KGQAGLQRALE 759

  Fly   748 FSAESASASAAPV-VRKNFAETWIFADIESTE--EEVFKWVKTIPDTITNWVVTGFSLHPQKGLG 809
            ...|........: ||..|.|.|::. :|:.:  :.:..|   :||::|.|.:.|.||...|||.
Human   760 ILQEEDLIDEDDIPVRSFFPENWLWR-VETVDRFQILTLW---LPDSLTTWEIHGLSLSKTKGLC 820

  Fly   810 VTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNE 874
            |.. ...::.|:.|.:.:|||.||:|.|.:.:..:::|||.|.|.|.:.:...:        ...
Human   821 VAT-PVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVE--------GLC 876

  Fly   875 VIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPL---AGDAIHKPLKVVPEGITQY 936
            :.|.....|.:.|.|..|...:|.:.|.....:.||..|....   .|||:.|.|::..||....
Human   877 LAGGGGLAQQVLVPAGSARPVAFSVVPTAAAAVSLKVVARGSFEFPVGDAVSKVLQIEKEGAIHR 941

  Fly   937 QNRAFFIN-LKDTGEFKNTFELEVP----EDVVPDSE-----RVEFGLVGDLLG------PVVKN 985
            :...:.:| |...|.     .||:|    .:::||.:     ||......|.||      |  ..
Human   942 EELVYELNPLDHRGR-----TLEIPGNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSP--GG 999

  Fly   986 LENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKK---LTPALDTRIKRNLQDGYQHMLHYRHDDG 1047
            :.:|||||.|||||||..|.|......||...::   |.|.........:|.||..:..:|..||
Human  1000 VASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADG 1064

  Fly  1048 SFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEH 1112
            |:::     |..    |:.||||||:||:..|..::.:....:.|.:...:||::|..:|||.:.
Human  1065 SYAA-----WLS----RDSSTWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQDP 1120

  Fly  1113 GEYFYSSQR-------------SLLTLTANSLLALLEEEKPN------QAAIDKAVAYLSANTAE 1158
            ......|.:             :.:|:..:..||:.::|...      :|:|.||.::|....
Human  1121 CPVLDRSMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKANSFLGEKA-- 1183

  Fly  1159 SIELL---PKSIAIYALQKAKAPEAAKQVA--SLKSLAKHEDDRTWW-------TEDLDKLRASK 1211
            |..||   ..:|..|||...|||.....||  :|.::|:...|..:|       :..:....|.:
Human  1184 SAGLLGAHAAAITAYALTLTKAPVDLLGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVSPTPAPR 1248

  Fly  1212 N-------CGRWWCWIWSQDVEITSYALLSLL--DSDQETADSVLNTVRWLIAQRNGFGGFASSQ 1267
            |       ....|       :|.|:||||.||  :...|.||   ....||..|.:..|||.|:|
Human  1249 NPSDPMPQAPALW-------IETTAYALLHLLLHEGKAEMAD---QASAWLTRQGSFQGGFRSTQ 1303

  Fly  1268 DTVVGLTALIKF------AEKSGYEAAKWEVTVSNKGK---REKTEKLNTSEENDLLLQTVEFPQ 1323
            |||:.|.||..:      .|:.|.     .||:|:.|:   :....:||..:... |.:.::|..
Human  1304 DTVIALDALSAYWIASHTTEERGL-----NVTLSSTGRNGFKSHALQLNNRQIRG-LEEELQFSL 1362

  Fly  1324 GTKSLEFEAKGTGAAMVQISYQYNLVEKEPK--PSFKIQTTV---------------------LP 1365
            |:| :..:..|.....:::...||:::.:..  ...:|:.||                     ||
Human  1363 GSK-INVKVGGNSKGTLKVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYTMEANEDYEDYEYDELP 1426

  Fly  1366 ---------------------------------ESSPANLELSVCVDYVEEGESKESNMAILEVS 1397
                                             |...:.:..:||:  ...|:...|.|||.:|:
Human  1427 AKDDPDAPLQPVTPLQLFEGRRNRRRREAPKVVEEQESRVHYTVCI--WRNGKVGLSGMAIADVT 1489

  Fly  1398 LPSGYTADEDSFADIRNIERV--RLV---ETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVAN 1457
            |.||:.|..   ||:..:..:  |.|   ||:...  |::||:::..:.| |:..||.:...|..
Human  1490 LLSGFHALR---ADLEKLTSLSDRYVSHFETEGPH--VLLYFDSVPTSRE-CVGFEAVQEVPVGL 1548

  Fly  1458 QKPSSVVLYDYYDTNKKATEYYSIKSK---LCDICEGDDC---KSKC 1498
            .:|:|..|||||:..::.:.:|...||   |..:|..:.|   :.||
Human  1549 VQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVCQCAEGKC 1595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	25/92 (27%)
		A2M_N_2	528..653	CDD:285005	27/129 (21%)
		A2M	768..859	CDD:278630	29/92 (32%)
		A2M_2	982..1279	CDD:239227	97/339 (29%)
		A2M_comp	1035..1281	CDD:284982	78/291 (27%)
		A2M_recep	1389..1479	CDD:284981	30/94 (32%)
C4A	NP_009224.2	A2M_N	141..233	CDD:280081	27/115 (23%)
		A2M_N	141..233		27/115 (23%)
		A2M_N_2	478..610	CDD:285005	32/151 (21%)
		A2M_N_2	478..610		32/151 (21%)
		ANATO	686..750	CDD:237984	11/71 (15%)
		ANATO	686..750		11/71 (15%)
		A2M	782..869	CDD:278630	29/91 (32%)
		A2M	782..869		29/91 (32%)
		complement_C3_C4_C5	996..1315	CDD:239226	98/341 (29%)
		complement_C3_C4_C5	996..1315		98/341 (29%)
		A2M_comp	1051..1317	CDD:284982	78/286 (27%)
		A2M_comp	1051..1317		78/286 (27%)
		A2M_recep	1481..1570	CDD:284981	30/94 (32%)
		A2M_recep	1481..1570		30/94 (32%)
		NTR_complement_C4	1588..1742	CDD:239639	3/8 (38%)
		NTR_complement_C4	1588..1742		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149973
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810