DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and C3

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_000055.2	Gene:	C3 / 718	HGNCID:	1318	Length:	1663	Species:	Homo sapiens

Alignment Length:	1701	Identity:	380/1701 - (22%)
Similarity:	652/1701 - (38%)	Gaps:	416/1701 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ILALLQTMEPVKAEGK--YTIVGPGTIHSHRDYNVAVAVH--QTKEPVTLKV-GITGPS--YNKT 71
            :|.||.|..|: |.|.  |:|:.|..:....:..:.:..|  |...|||:.| ...|..  .:..
Human     9 LLLLLLTHLPL-ALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSE 72

  Fly    72 ETVELATAGEFKQITFKLP-----PLEAGEYN-LTAEGVKGLEFKNSTKL-NWENFKPYIKIQTD 129
            :||..........:||.:|     ..|.|... :|.:...|.:......| :.::  .|:.||||
Human    73 KTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLVSLQS--GYLFIQTD 135

  Fly   130 KGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEK-HIKTTGGVYTGKFELSEF 193
            |..|.||.|:.||:..::..|.|  ....|:|..|:.:...:||:. ..:...||....:::.|.
Human   136 KTIYTPGSTVLYRIFTVNHKLLP--VGRTVMVNIENPEGIPVKQDSLSSQNQLGVLPLSWDIPEL 198

  Fly   194 ATLGSWSL--HVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQ 256
            ..:|.|.:  :.:|..|           :.|.            ..|||::||||.:.|.::.|:
Human   199 VNMGQWKIRAYYENSPQ-----------QVFS------------TEFEVKEYVLPSFEVIVEPTE 240

  Fly   257 QVSVRDGE--FNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMV 319
            :......|  ..|.:.|.:.|||.|.|...|                          :.|..|
Human   241 KFYYIYNEKGLEVTITARFLYGKKVEGTAFV--------------------------IFGIQD-- 277

  Fly   320 GGKAKLTMDLKDFASYLPHKTSSSYAQITATV---------EEDFTGVKLNETGGVQLY------ 369
             |:.:::  |.:....:|.:..|....::..|         .||..|..|..:..|.|:
Human   278 -GEQRIS--LPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMV 339

  Fly   370 ------------PYRYEMSCT-DYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGI 421
                        ||:...:.| .|     |||....:|...:|..|||........|:
Human   340 QAERSGIPIVTSPYQIHFTKTPKY-----FKPGMPFDLMVFVTNPDGSPAYRVPVAVQ------- 392

  Fly   422 RRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKV-VLPDLPDIANFTRYYSIELEFV 485
                     |.|       |::..|       ...|||...: ..|....::...|....||...
Human   393 ---------GED-------TVQSLT-------QGDGVAKLSINTHPSQKPLSITVRTKKQELSEA 434

  Fly   486 DEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSR----PLKY 546
            ::........||   ..:.|.::.......|.|: ||.:..|:..      :|...|    .::|
Human   435 EQATRTMQALPY---STVGNSNNYLHLSVLRTEL-RPGETLNVNF------LLRMDRAHEAKIRY 489

  Fly   547 FVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTT---PYGRVYFYY--VDETGEFRYTEETF 606
            :.|.|:.:|.:|:..| .:.||..  ::.:.|..:||   |..|:..||  :..:|:.....::.
Human   490 YTYLIMNKGRLLKAGR-QVREPGQ--DLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSV 551

  Fly   607 SVEVE---------LQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNK 662
            .|:|:         ...|.|.:.|.   ||..:.|:|:....:.|.|:|||:.|.:|...|.|.:
Human   552 WVDVKDSCVGSLVVKSGQSEDRQPV---PGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQ 613

  Fly   663 ESFNWRL-----------NGYD------------TSTPWQ------------------------- 679
            ... |.:           :|.|            ||:..|
Human   614 SKI-WDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTE 677

  Fly   680 ---GGYSYYPGE--------------------RTGVVTMTNAYFFYNRTAPD-YNILTEGFGGSS 720
               .....||.|                    ||..:::..|   ..:...| .|.:||
Human   678 KRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEA---CKKVFLDCCNYITE------ 733

  Fly   721 FAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWV 785
              :|:.         |:.|.....|.....|...|....|.|..|.|:|:: ::|..:|.....:
Human   734 --LRRQ---------HARASHLGLARSNLDEDIIAEENIVSRSEFPESWLW-NVEDLKEPPKNGI 786

  Fly   786 KT------IPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPAL 844
            .|      :.|:||.|.:...|:..:||:.|. |...:...|.||:.:||||||.|.|.:.:.|:
Human   787 STKLMNIFLKDSITTWEILAVSMSDKKGICVA-DPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAV 850

  Fly   845 VFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGD----------QKRTQNIRVGANEAAGASFLI 899
            ::||            .::||   :....|::.:          ::..|.:.:....:....::|
Human   851 LYNY------------RQNQE---LKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVI 900

  Fly   900 RPKVIG--NILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEF--KNTFELEVP 960
            .|...|  .:.:|.........|.:.|.||||||||.  .|:...:...|....  :...:.::|
Human   901 VPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIR--MNKTVAVRTLDPERLGREGVQKEDIP 963

  Fly   961 ----EDVVPDSE-RVEFGLVGDLLGPVVKN------LENLLRLPSGCGEQTMSKLVPNYLVRDYL 1014
                .|.|||:| .....|.|..:..:.::      |::|:..|||||||.|..:.|..:...||
Human   964 PADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYL 1028

  Fly  1015 K--------SIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLT 1071
            .        .::|...||:.     ::.||...|.:|....:|::|         ..|..|||||
Human  1029 DETEQWEKFGLEKRQGALEL-----IKKGYTQQLAFRQPSSAFAAF---------VKRAPSTWLT 1079

  Fly  1072 AYVLRSFSKIKDIIDLDEQILAKGYEFL-LTRQAENGSFTEHGEYFY--------SSQRSLLTLT 1127
            |||::.||...::|.:|.|:|....::| |.:|..:|.|.|.....:        ::....:.||
Human  1080 AYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALT 1144

  Fly  1128 ANSLLALLE-----EEKPNQ--AAIDKAVAYLSANTAESIELLPKSIAIYALQ---KAKAPEAAK 1182
            |..|::|.|     ||:.|.  .:|.||..:|.||..........:||.|||.   :.|.|...|
Human  1145 AFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNK 1209

  Fly  1183 QVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVL 1247
            .:.:.|       |:..|.:...:|               .:||.||||||:||  ..:..|.|.
Human  1210 FLTTAK-------DKNRWEDPGKQL---------------YNVEATSYALLALL--QLKDFDFVP 1250

  Fly  1248 NTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKS-GYEAAKWEVTVSNKGKREK-TEKLNTSE 1310
            ..||||..||...||:.|:|.|.:...||.::.:.: .::....:|::....:..| |.:::.
Human  1251 PVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHW-- 1313

  Fly  1311 ENDLLLQTVEFPQGTKSLE-----FEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLP----E 1366
            |:..||::.|    ||..|     .|.||.|...|...|.....::.....|.::.|:.|    |
Human  1314 ESASLLRSEE----TKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETE 1374

  Fly  1367 SSPANLE----LSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRN-----IERVRLVE 1422
            ..|.:.:    |.:|..|  .|: :::.|:||::|:.:|:..|.|....:.|     |.:..|.:
Human  1375 KRPQDAKNTMILEICTRY--RGD-QDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDK 1436

  Fly  1423 TKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIK---SK 1484
            ..:..:.::||.:.::.:|:.|:..:.::...|...:|.:|.:|.||:..:..|.:|..:   .|
Human  1437 AFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGK 1501

  Fly  1485 LCDICEGDDCK 1495
            |..:|..:.|:
Human  1502 LNKLCRDELCR 1512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	25/95 (26%)
		A2M_N_2	528..653	CDD:285005	33/142 (23%)
		A2M	768..859	CDD:278630	27/96 (28%)
		A2M_2	982..1279	CDD:239227	95/329 (29%)
		A2M_comp	1035..1281	CDD:284982	79/264 (30%)
		A2M_recep	1389..1479	CDD:284981	21/94 (22%)
C3	NP_000055.2	A2M_N	129..224	CDD:280081	28/119 (24%)
		A2M_N_2	458..604	CDD:285005	38/158 (24%)
		ANATO	678..747	CDD:237984	13/88 (15%)
		A2M	770..866	CDD:278630	29/112 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	954..973		3/18 (17%)
		complement_C3_C4_C5	996..1282	CDD:239226	95/323 (29%)
		A2M_comp	1051..1282	CDD:284982	79/263 (30%)
		A2M_recep	1398..1493	CDD:284981	21/94 (22%)
		NTR_complement_C3	1513..1661	CDD:239638	380/1701 (22%)
		Interaction with CFP/properdin. /evidence=ECO:0000269\|PubMed:28264884, ECO:0000269\|PubMed:31507604	1634..1659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149985
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.800