DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep4 and PZP

DIOPT Version :9

Sequence 1:NP_001260590.1 Gene:Tep4 / 35248 FlyBaseID:FBgn0041180 Length:1498 Species:Drosophila melanogaster
Sequence 2:XP_011519106.1 Gene:PZP / 5858 HGNCID:9750 Length:1500 Species:Homo sapiens


Alignment Length:1623 Identity:417/1623 - (25%)
Similarity:680/1623 - (41%) Gaps:308/1623 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MRRADAFAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITG 65
            ||:.....:.|.::|.||...:....|.:|.::.|..:|:.......|.:....|.||:...:..
Human     1 MRKDRLLHLCLVLLLILLSASDSNSTEPQYMVLVPSLLHTEAPKKGCVLLSHLNETVTVSASLES 65

  Fly    66 PSYNKTETVELATAGE-FKQITFKLPPLEA-GEYNLTAEGVKG--LEFKNSTKLNWENFKPYIKI 126
            ...|::...:|....: |..::|.||.:.| .|....:..:||  .:|:....:...|.:..:.:
Human    66 GRENRSLFTDLVAEKDLFHCVSFTLPRISASSEVAFLSIQIKGPTQDFRKRNTVLVLNTQSLVFV 130

  Fly   127 QTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVV--VWFEDSKRNRIKQEKHIKTTGGVYTGKFE 189
            ||||..||||.|:.:||:.:|||.||   ::|::  ::.|:.:||||.|.:.:|...|:....|.
Human   131 QTDKPMYKPGQTVRFRVVSVDENFRP---RNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFP 192

  Fly   190 LSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDA 254
            ||.....||:.:.||...         |||.|.              .|.||::||||:.||:..
Human   193 LSSEPIQGSYRVVVQTES---------GGRIQH--------------PFTVEEFVLPKFEVKVQV 234

  Fly   255 TQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMV 319
            .:.:|:.|.:.|:.:...|||||||.|...|:: ....|...|.|.:.|                
Human   235 PKIISIMDEKVNITVCGEYTYGKPVPGLATVSL-CRKLSRVLNCDKQEV---------------- 282

  Fly   320 GGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCF 384
                     .::|:..|     :|...||..|....  :::..||        :||.....:.. 
Human   283 ---------CEEFSQQL-----NSNGCITQQVHTKM--LQITNTG--------FEMKLRVEARI- 322

  Fly   385 SFKPDKEHELNFKITYVDGSLITDTKSVVK-AKFTEGIRRNYAFYA--FGTDHQEPELP------ 440
                 :|...:.::|....|.||:..|.:| .|.....|:...|:|  ...|.:...:|      
Human   323 -----REEGTDLEVTANRISEITNIVSKLKFVKVDSHFRQGIPFFAQVLLVDGKGVPIPNKLFFI 382

  Fly   441 TIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSI------ELEFVDEKR---------- 489
            ::....:...:..|..|:|.|.:....:.....|.|.:::      ...:|.|..          
Human   383 SVNDANYYSNATTNEQGLAQFSINTTSISVNKLFVRVFTVHPNLCFHYSWVAEDHQGAQHTANRV 447

  Fly   490 -DLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLK--YFVYNI 551
             .|..:|.:.||.....|....|                 .|...|.:...:...|.  .|.|.|
Human   448 FSLSGSYIHLEPVAGTLPCGHTE-----------------TITAHYTLNRQAMGELSELSFHYLI 495

  Fly   552 VGRGNIL----ETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVEL 612
            :.:|.|:    .|..|:..:.:.:..::........|..|::.:.:...||.....|.|.:|..|
Human   496 MAKGVIVRSGTHTLPVESGDMKGSFALSFPVESDVAPIARMFIFAILPDGEVVGDSEKFEIENCL 560

  Fly   613 QNQIEIK-APAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTST 676
            .|::::. :||:..|.:...|::..:|:|...|.||||||||:....:|:..|.      |:..|
Human   561 ANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLMKPEAELSVSSV------YNLLT 619

  Fly   677 PWQGGYSYYPGERTGVVTMTN-----------------AYFFYN---------RTAPDYNILTEG 715
                           |..:||                 .:|.:|         ..|..|:.| :|
Human   620 ---------------VKDLTNFPDNVDQQEEEQGHCPRPFFIHNGAIYVPLSSNEADIYSFL-KG 668

  Fly   716 FGGSSFAMRKTTVAHDSHVFHS-----------GAG------------GPTQAVGFSAESASASA 757
            .|...|...|........|..|           |||            |....:..:.|.:|...
Human   669 MGLKVFTNSKIRKPKSCSVIPSVSAGAVGQGYYGAGLGVVERPYVPQLGTYNVIPLNNEQSSGPV 733

  Fly   758 APVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQP 822
            ...||..|.||||:..:......|.:...|:|||||.|....|.|....|||::: ..:::.|||
Human   734 PETVRSYFPETWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISS-TASLRAFQP 797

  Fly   823 FFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQ--KRTQNI 885
            |||.:.:||||.||||..:.|.|.|||||.:.|.:.|          .||...:..|  |..::.
Human   798 FFVELTMPYSVIRGEVFTLKATVLNYLPKCIRVSVQL----------KASPAFLASQNTKGEESY 852

  Fly   886 RVGANEAAGASFLIRPKVIGNILLKFKAIS----PLAG------------DAIHKPLKVVPEGIT 934
            .:..||....|:.:.||.:||:.....|.:    .|.|            |.:.|.|.|..|||.
Human   853 CICGNERQTLSWTVTPKTLGNVNFSVSAEAMQSLELCGNEVVEVPEIKRKDTVIKTLLVEAEGIE 917

  Fly   935 QYQNRAF-FINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGE 998
              |.:.| .:.............|::|.:||.:|.|..|.::||:||..::|::|||::|.||||
Human   918 --QEKTFSSMTCASGANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGE 980

  Fly   999 QTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPV 1063
            |.|....||..|.:||...::||..:..:....|..|||..|:|:|.|||:|:||....|.:   
Human   981 QNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGRNQ--- 1042

  Fly  1064 RNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQRSLL---- 1124
              |:|||||:||::|::.:..|.:||..:.:...:|...|.:||.|...|....::.:..:    
Human  1043 --GNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEA 1105

  Fly  1125 TLTANSLLALLEEEKP-NQAAIDKAVAYLSA--NTAE----SIELLPKSIAIYALQ-KAKAPEAA 1181
            ||:|...:||||...| ....:..|:..|.:  |.|:    ...:..|::..||.. ..|..:..
Human  1106 TLSAYVTIALLEIPLPVTNPIVRNALFCLESAWNVAKEGTHGSHVYTKALLAYAFSLLGKQNQNR 1170

  Fly  1182 KQVASLKSLAKHEDDRTWWTE---------DLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLD 1237
            :.:.||...|..||:...|..         .|.:.:|.           |.:||:|||.||:.|.
Human  1171 EILNSLDKEAVKEDNLVHWERPQRPKAPVGHLYQTQAP-----------SAEVEMTSYVLLAYLT 1224

  Fly  1238 SDQETAD----SVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKW-------E 1291
            :......    |..|.|:|::.|:|..|||:|:|||||.|.||      |.|.||.:       :
Human  1225 AQPAPTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHAL------SRYGAATFTRTEKTAQ 1283

  Fly  1292 VTVSNKGKREKTEKLNTSEEND--LLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLV-EKEP 1353
            |||.:    .:|...|...:|:  ||||.:..|:..........|.....:|.|.:||:: |||.
Human  1284 VTVQD----SQTFSTNFQVDNNNLLLLQQISLPELPGEYVITVTGERCVYLQTSMKYNILPEKED 1344

  Fly  1354 KP-SFKIQTTVLPES-----SPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADI 1412
            .| :.|:||  :|::     :..:.::|:.:.|.  |....|||.|::|.:.||:...:.:   :
Human  1345 SPFALKVQT--VPQTCDGHKAHTSFQISLTISYT--GNRPASNMVIVDVKMVSGFIPLKPT---V 1402

  Fly  1413 RNIERVRLV-ETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKK 1474
            :.:||...| .|:..::.|:||.|.:. |:.........:...|.:.||:.|.:||||:|..|
Human  1403 KMLERSSSVSRTEVSNNHVLIYVEQVT-NQTLSFSFMVLQDIPVGDLKPAIVKVYDYYETGIK 1464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep4NP_001260590.1 A2M_N 126..219 CDD:280081 33/94 (35%)
A2M_N_2 528..653 CDD:285005 32/131 (24%)
A2M 768..859 CDD:278630 38/90 (42%)
A2M_2 982..1279 CDD:239227 101/321 (31%)
A2M_comp 1035..1281 CDD:284982 82/270 (30%)
A2M_recep 1389..1479 CDD:284981 26/87 (30%)
PZPXP_011519106.1 A2M_N 128..220 CDD:280081 37/117 (32%)
A2M_N_2 457..602 CDD:285005 36/161 (22%)
A2M 744..834 CDD:278630 38/90 (42%)
SVA <796..891 CDD:283081 35/104 (34%)
A2M_2 964..1270 CDD:239227 102/327 (31%)
A2M_comp 1016..1272 CDD:284982 84/277 (30%)
A2M_recep 1382..1464 CDD:284981 25/85 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149981
Domainoid 1 1.000 84 1.000 Domainoid score I8230
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X292
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.650

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