DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and cd109

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_697512.6	Gene:	cd109 / 569058	ZFINID:	ZDB-GENE-120215-253	Length:	1487	Species:	Danio rerio

Alignment Length:	1538	Identity:	392/1538 - (25%)
Similarity:	675/1538 - (43%)	Gaps:	236/1538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PVTLKVGITGPSYNKTETVELATAGEFKQITFKLPPLEAGE------YNLTAEGVKG--LEFKNS 112
            |:.:...:|....:..:|.....||..:.::  |||:...:      |.|..||..|  |.|.||
Zfish    56 PINVTARLTHGKTSVAQTQSTVPAGSSRLLS--LPPVFYDDMTYWYPYQLNVEGFSGTHLVFSNS 118

  Fly   113 TKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHI 177
            |.:.:......|.|||||..|:||.|:.:||:.:..:.:|.:.:.::.:  .|.:.|.|:|...:
Zfish   119 TSMVFSPRCMSIFIQTDKNYYQPGQTVKFRVVSVTPDGKPYSGRTDIFI--RDPRGNMIRQWLAV 181

  Fly   178 KTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEK 242
            .:..||.:.:..:|:...||||.:.....|..|:..                        |.|:.
Zfish   182 DSFLGVISKELNISQNPPLGSWKITAGVNDVIHERA------------------------FTVDY 222

  Fly   243 YVLPKYSVKMDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVN-VHLDSTSSWENVDGKTVQTD 306
            ||||::.||:|....:...|.....| .|.|.|||||:|.:.|. ||        ..:|..::.|
Zfish   223 YVLPRFEVKLDVPSVLYCEDTLMGTV-TAKYFYGKPVSGFMDVRFVH--------GFNGIEMRYD 278

  Fly   307 YPGHSVVGTADMVGGKAKLTMDLKDFA--------SYLPHKTSSSYAQITATVEEDFTGVKLNET 363
            :        .:|:.|.|::|.|:|||:        ||........:..:...:.|..||:..|.:
Zfish   279 H--------TEMIEGSAEITFDMKDFSTRFNDYSYSYYDGYRPIEFIDVNVNITESATGLMYNSS 335

  Fly   364 GGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDG---SLITDTKSVVKA---------- 415
            ..|.:...:|::....|...  .||........|::..|.   |.....:||..|
Zfish   336 ARVSIVTEKYKLEFLQYPHI--VKPSMTFTAKLKLSLYDQRPLSAEDQIESVYLAVTQHKLSPWT 398

  Fly   416 -KFTEG------IRRNYAFYAFGTDHQEPEL--------------PTIEKKTFVFESHLNASGVA 459
             .:::|      :..|....:|..:.....|              |..:......|..:.|.|:.
Zfish   399 WMWSDGGPLGPRMMNNTPSTSFPPNSDGGPLGPHMMNSTPPTSFTPIYDLPVQNIELPVTADGLM 463

  Fly   460 PFKVVLPDLPDIANFTRYYSIELEFVD--EKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRP 522
            .|::.|.|  .:|..    .:|..|.|  :...||.:|        .:||        ::.:|..
Zfish   464 SFQIHLSD--SVATL----DLEARFKDTVQHLQLYRSY--------SSPS--------KSYIQLH 506

  Fly   523 KDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGR 587
            :|. ..::|:.....|.||..|....|.:..|..:     ||....|:: :.::....|..|...
Zfish   507 RDS-EPQVGRSLNFTLESSFNLTKIHYLVTSRAGV-----VDAGTVQSS-SFSLNTDHLWAPQAC 564

  Fly   588 VYFYYVDETGEFRYTEETFSVEVELQNQIEIK-APAEVKPGADVALEIKTS-PKSFVGLLAVDQS 650
            |..||....||........|....|:|.:.:: :....:|...|:|.:..| |.|.:|:|.||::
Zfish   565 VMVYYTLPDGEIVNDALHVSFTKVLRNTVSVRWSQDRAEPAESVSLSVSVSEPGSVLGILVVDKA 629

  Fly   651 VLLLGSNNDLNKESFNWRLNGYD---TSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNIL 712
            .|....:|.|::::.......|.   |.|..:|            :.|.:.|..:  ||....:|
Zfish   630 TLNSAEDNGLSEKTVLEEFLSYSREMTHTDNRG------------MKMGDPYSVF--TACGVTVL 680

  Fly   713 TEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIEST 777
            |:       |.....:|.:..:|....|  .:.:..:|...|:...|..||:|.||||:.|...:
Zfish   681 TD-------ARLNQEMATNQEMFPMFPG--EEGLFMTAMPDSSIQEPRQRKDFPETWIWLDANVS 736

  Fly   778 EEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVP 842
            :.....:..|:||::|:|......:....|||: :....:..|:.||:|:.||..:.|||::.:.
Zfish   737 DSASAVFSLTVPDSLTSWAAFAIIMSENLGLGI-SAPAELTVFRDFFMSLDLPAFLIRGELLLLE 800

  Fly   843 ALVFNYLPKTLDVELTLDNEDQEYDFV--DASNEVIGDQKR----TQNIRVGANEAAGASFLIRP 901
            ..:|||:...|:| :.:..|...::||  |:::..:.:.::    :||..:       ..|.|:.
Zfish   801 VNLFNYMDVDLEV-IVVVAESGMFEFVSTDSADFSVANVRKVLVLSQNFTM-------LLFPIKA 857

  Fly   902 KVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINL---KDTGEFKNTFELEVPEDV 963
            ..:|.|.:..||.|..:.|.::|.:.|.|||:.|...:..|:..   :.|...|.||..  |.||
Zfish   858 TTLGEIPISVKATSVYSSDWLYKTVLVKPEGLQQSFTQTLFLEFLLQQHTLSRKMTFSF--PADV 920

  Fly   964 VPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRI 1028
            ||:|:|.....|||:|||.:.||::|:.:|.|||||.|....||..|..||||.|:.......:.
Zfish   921 VPNSQRASVSAVGDILGPSIGNLDSLIEMPYGCGEQNMIHFAPNTYVLQYLKSTKQAEEQTRRKA 985

  Fly  1029 KRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILA 1093
            ...:.:.|:..|.|:..|||||:||       |...:|||||:|:|||.|.:.:|.|.::..::.
Zfish   986 MSYMMEAYERELSYQRVDGSFSAFG-------DSDESGSTWLSAFVLRCFLQARDFISIEPLVME 1043

  Fly  1094 KGYEFLLTRQAENGSFTEHGEYFYSSQRSLL----TLTANSLLALLEE---EKPNQAAIDKAVAY 1151
            :...:|:..|..:|||.|.|:..::..:..|    :|||..|:||||:   |..::.::..|:::
Zfish  1044 RTAFWLVAHQESDGSFREPGQVIHTELQGGLDGSVSLTAYVLIALLEDAKYESTHKDSVSLALSF 1108

  Fly  1152 LSANTAESIEL-LPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGR 1215
            |::..|:.|.. ...|:..|||..||:..|...:.:|.:.|...|....|......|..|
Zfish  1109 LTSRLAQGISSNYSLSLVAYALSLAKSSAAPSALTTLLNRALVIDGVPTWRSPGSVLYDS----- 1168

  Fly  1216 WWCWIW---SQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALI 1277
                 |   |.|:||.:|.||::  ......|.....::||..|||..||:.|:||||:.|.||.
Zfish  1169 -----WQPRSADIEIAAYVLLTM--HSLRLMDEGFALMKWLSQQRNHLGGYGSTQDTVMALHALS 1226

  Fly  1278 KFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTK---SLEFEAKGTGAAM 1339
            .:|..|..|:....:.|:.......|..::.|  |.||.|:.:.|..:|   .:|.||:|||.|:
Zfish  1227 VYATFSSAESMDLTIRVNEGSGTVATFSIDKS--NYLLQQSHDLPIESKDGVDIEVEAEGTGFAL 1289

  Fly  1340 VQISYQYNLV---------EKEPKPSFKIQTTVLPESSPANLELSVCVDYVEEGES-KESNMAIL 1394
            .|::..||::         :.....:|.:...:: :....::.|..|. .:..|:. .::.||||
Zfish  1290 FQLTVFYNVMNVRRSLRRRDIHTDEAFYLYVDIM-DKEEYHVNLYTCF-RLRGGQGLNQTGMAIL 1352

  Fly  1395 EVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQK 1459
            :|.|.:|::..:|.   ::..:.||.|||.:|.  |::|.:.:. ..|:||.|.......||..:
Zfish  1353 DVGLLTGFSLAQDG---VQIDDTVRRVETPSGR--VILYLDKVT-TVEQCIEISTVMDFKVAGVQ 1411

  Fly  1460 PSSVVLYDYYDTNKKATEYYSIKSK----LCDICEGDDCKSKC 1498
            .:.:::||||:..::....|:.:.:    :|..| |.|| |.|
Zfish  1412 DAVIMIYDYYEPRRRTVRSYTSERRRDMSVCSFC-GSDC-SLC 1452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	25/92 (27%)
		A2M_N_2	528..653	CDD:285005	30/126 (24%)
		A2M	768..859	CDD:278630	26/90 (29%)
		A2M_2	982..1279	CDD:239227	99/307 (32%)
		A2M_comp	1035..1281	CDD:284982	81/256 (32%)
		A2M_recep	1389..1479	CDD:284981	26/89 (29%)
cd109	XP_697512.6	A2M_N	129..220	CDD:280081	27/116 (23%)
		A2M_N_2	510..632	CDD:285005	30/127 (24%)
		A2M	727..817	CDD:278630	26/91 (29%)
		A2M_2	939..1228	CDD:239227	99/307 (32%)
		A2M_comp	991..1230	CDD:284982	81/257 (32%)
		A2M_recep	1347..1431	CDD:284981	26/89 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584111
Domainoid	1	1.000	75	1.000	Domainoid score	I8988
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		otm24980
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.860